Ror1 receptor tyrosine kinase-like orphan receptor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ror1provided by RGD
Official Full Name: receptor tyrosine kinase-like orphan receptor 1provided by RGD
Primary source: RGD:1559469
See related: Ensembl:ENSRNOG00000029449 AllianceGenome:RGD:1559469
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1559469
Summary: Predicted to enable Wnt-activated receptor activity and Wnt-protein binding activity. Involved in astrocyte development. Located in cell surface; cytoplasm; and stress fiber. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 108. Orthologous to human ROR1 (receptor tyrosine kinase like orphan receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 33.5), Uterus (RPKM 31.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q33

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (119859744..120203573)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (114744311..115088155)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (118892874..119239528)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ROR1 was one of the most significantly regulated receptor tyrosine kinases in the ischemic heart and may be a potential target for the treatment of ischemic heart injury.
Title: Receptor tyrosine kinase profiling of ischemic heart identifies ROR1 as a potential therapeutic target.

Submit: New GeneRIF Correction

General gene information

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Markers

01.MMHAP71FRA7.seq (e-PCR)
- UniSTS:122671

D5Rat72 (e-PCR), detects polymorphism
- UniSTS:227964

RH144647 (e-PCR)
- UniSTS:233892

AU027086 (e-PCR)
- UniSTS:113647

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables Wnt receptor activity	ISO Inferred from Sequence Orthology more info
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	ISO Inferred from Sequence Orthology more info
NOT enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in astrocyte development	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in inner ear development	ISO Inferred from Sequence Orthology more info
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon terminus	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
located_in stress fiber	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: inactive tyrosine-protein kinase transmembrane receptor ROR1

Names: neurotrophic tyrosine kinase, receptor-related 1; tyrosine-protein kinase transmembrane receptor ROR1

NP_001102141.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108671.1 → NP_001102141.1 inactive tyrosine-protein kinase transmembrane receptor ROR1 precursor

See identical proteins and their annotated locations for NP_001102141.1

Status: PROVISIONAL

Source sequence(s)

CH473998

UniProtKB/TrEMBL

A0A8I5ZQX3, A6JRM7, D3ZZ97

Related

ENSRNOP00000044602.3, ENSRNOT00000045987.3

Conserved Domains (6) summary

cd07467
Location:166 → 307

CRD_TK_ROR1; Cysteine-rich domain of tyrosine kinase-like orphan receptor 1

smart00408
Location:72 → 137

IGc2; Immunoglobulin C-2 Type

smart00130
Location:311 → 393

KR; Kringle domain

smart00410
Location:66 → 148

IG_like; Immunoglobulin like

cd05090
Location:467 → 749

PTKc_Ror1; Catalytic domain of the Protein Tyrosine Kinase, Receptor tyrosine kinase-like Orphan Receptor 1

pfam07714
Location:473 → 746

Pkinase_Tyr; Protein tyrosine kinase