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Ndufa9 NADH:ubiquinone oxidoreductase subunit A9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362440, updated on 5-Mar-2024

Summary

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Official Symbol
Ndufa9provided by RGD
Official Full Name
NADH:ubiquinone oxidoreductase subunit A9provided by RGD
Primary source
RGD:1307307
See related
Ensembl:ENSRNOG00000061684 AllianceGenome:RGD:1307307
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable NADH dehydrogenase activity. Involved in response to glucose. Located in mitochondrion. Human ortholog(s) of this gene implicated in nuclear type mitochondrial complex I deficiency 26. Orthologous to human NDUFA9 (NADH:ubiquinone oxidoreductase subunit A9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 2222.8), Muscle (RPKM 1592.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q42
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (161345398..161374188, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (159659242..159688034, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (159371263..159399636, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily A member 6 Neighboring gene polypeptide N-acetylgalactosaminyltransferase 8 Neighboring gene uncharacterized LOC134486843 Neighboring gene A-kinase anchoring protein 3 Neighboring gene dual specificity tyrosine phosphorylation regulated kinase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Increased enzymatic O-GlcNAcylation of mitochondrial proteins impairs mitochondrial function in cardiac myocytes exposed to high glucose. Hu Y, et al. J Biol Chem, 2009 Jan 2. PMID 19004814, Free PMC Article
  2. Construction and evaluation of a hncDNA library of human 12p transcribed sequences derived from a somatic cell hybrid. Baens M, et al. Genomics, 1993 Apr. PMID 8486360
  3. Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy. Kruse SE, et al. Cell Metab, 2008 Apr. PMID 18396137, Free PMC Article
  4. CLOCK Acetylates ASS1 to Drive Circadian Rhythm of Ureagenesis. Lin R, et al. Mol Cell, 2017 Oct 5. PMID 28985504
  5. Partial complex I deficiency due to the CNS conditional ablation of Ndufa5 results in a mild chronic encephalopathy but no increase in oxidative damage. Peralta S, et al. Hum Mol Genet, 2014 Mar 15. PMID 24154540, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables NADH dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables NADH dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in circadian rhythm IEA
Inferred from Electronic Annotation
more info
  
involved_in circadian rhythm ISO
Inferred from Sequence Orthology
more info
  
involved_in circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrial respiratory chain complex I assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrial respiratory chain complex I assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in response to glucose IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in ubiquinone-6 biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial respiratory chain complex I IEA
Inferred from Electronic Annotation
more info
  
part_of mitochondrial respiratory chain complex I ISO
Inferred from Sequence Orthology
more info
  
part_of mitochondrial respiratory chain complex I ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial
Names
CI-39kD
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9
NADH-ubiquinone oxidoreductase 39 kDa subunit
complex I-39kD
sperm flagella protein 3
NP_001094222.1
XP_006237562.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100752.1 → NP_001094222.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

    See identical proteins and their annotated locations for NP_001094222.1

    Status: PROVISIONAL

    Source sequence(s)
    BC168777
    UniProtKB/Swiss-Prot
    B5DER7, Q5BK63
    UniProtKB/TrEMBL
    A0A8L2R6R3
    Related
    ENSRNOP00000072757.2, ENSRNOT00000089193.2
    Conserved Domains (1) summary
    cd05271
    Location:54 → 326
    NDUFA9_like_SDR_a; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    161345398..161374188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006237500.3 → XP_006237562.1  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8L2R6R3
    Related
    ENSRNOP00000085680.1
    Conserved Domains (2) summary
    cd05271
    Location:50 → 322
    NDUFA9_like_SDR_a; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs
    pfam01370
    Location:52 → 259
    Epimerase; NAD dependent epimerase/dehydratase family
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BK63.2 GenPept UniProtKB/Swiss-Prot:Q5BK63

Gene LinkOut

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