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Impdh1 inosine monophosphate dehydrogenase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362329, updated on 13-Apr-2024

Summary

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Official Symbol
Impdh1provided by RGD
Official Full Name
inosine monophosphate dehydrogenase 1provided by RGD
Primary source
RGD:1311108
See related
Ensembl:ENSRNOG00000020032 AllianceGenome:RGD:1311108
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
IMPD 1; IMPDH 1
Summary
Predicted to enable DNA binding activity; IMP dehydrogenase activity; and identical protein binding activity. Involved in response to cold and retina development in camera-type eye. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 11; retinitis pigmentosa; and retinitis pigmentosa 10. Orthologous to human IMPDH1 (inosine monophosphate dehydrogenase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 281.3), Adrenal (RPKM 210.2) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q22
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (58767230..58782825, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (57801842..57817434, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (56478383..56493987, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene RNA binding motif protein 28 Neighboring gene proline-rich transmembrane protein 4 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene uncharacterized LOC134486744 Neighboring gene hypoxia inducible lipid droplet-associated

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Therapeutic benefit derived from RNAi-mediated ablation of IMPDH1 transcripts in a murine model of autosomal dominant retinitis pigmentosa (RP10). Tam LC, et al. Hum Mol Genet, 2008 Jul 15. PMID 18385099
  2. Synchronized changes in transcript levels of genes activating cold exposure-induced thermogenesis in brown adipose tissue of experimental animals. Watanabe M, et al. Biochim Biophys Acta, 2008 Jan. PMID 18036333
  3. Characterisation of inosine monophosphate dehydrogenase expression during retinal development: differences between variants and isoforms. Gunter JH, et al. Int J Biochem Cell Biol, 2008. PMID 18295529
  4. On the molecular pathology of neurodegeneration in IMPDH1-based retinitis pigmentosa. Aherne A, et al. Hum Mol Genet, 2004 Mar 15. PMID 14981049
  5. Mutations in the inosine monophosphate dehydrogenase 1 gene (IMPDH1) cause the RP10 form of autosomal dominant retinitis pigmentosa. Bowne SJ, et al. Hum Mol Genet, 2002 Mar 1. PMID 11875050, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables IMP dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables IMP dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables IMP dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' XMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in GMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in GMP biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in GTP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lymphocyte proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within purine nucleotide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in retina development in camera-type eye IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
inosine-5'-monophosphate dehydrogenase 1
Names
IMP (inosine 5'-monophosphate) dehydrogenase 1
IMP (inosine monophosphate) dehydrogenase 1
IMP dehydrogenase 1
inosine 5'-phosphate dehydrogenase 1
NP_001102089.1
NP_001385786.1
XP_006236272.2
XP_038963701.1
XP_063142307.1
XP_063142308.1
XP_063142309.1
XP_063142310.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108619.1 → NP_001102089.1  inosine-5'-monophosphate dehydrogenase 1 isoform 1

    See identical proteins and their annotated locations for NP_001102089.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473959
    UniProtKB/TrEMBL
    A0A8I6AI29, A6IEC0
    Conserved Domains (3) summary
    cd00381
    Location:86 → 527
    IMPDH; IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine ...
    cd04602
    Location:172 → 264
    CBS_pair_IMPDH_2; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key ...
    PTZ00314
    Location:71 → 544
    PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

  2. NM_001398857.1 → NP_001385786.1  inosine-5'-monophosphate dehydrogenase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    D3ZLZ7
    Conserved Domains (1) summary
    PTZ00314
    Location:14 → 510
    PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    58767230..58782825 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286239.1 → XP_063142309.1  inosine-5'-monophosphate dehydrogenase 1 isoform X3

  2. XM_063286237.1 → XP_063142307.1  inosine-5'-monophosphate dehydrogenase 1 isoform X1

  3. XM_039107773.2 → XP_038963701.1  inosine-5'-monophosphate dehydrogenase 1 isoform X5

    UniProtKB/TrEMBL
    A0A8I6AI29
    Related
    ENSRNOP00000027173.7
    Conserved Domains (1) summary
    PTZ00314
    Location:71 → 542
    PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

  4. XM_006236210.4 → XP_006236272.2  inosine-5'-monophosphate dehydrogenase 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6AI29
    Related
    ENSRNOP00000095077.1
    Conserved Domains (1) summary
    PTZ00314
    Location:71 → 567
    PTZ00314; inosine-5'-monophosphate dehydrogenase; Provisional

  5. XM_063286240.1 → XP_063142310.1  inosine-5'-monophosphate dehydrogenase 1 isoform X6

  6. XM_063286238.1 → XP_063142308.1  inosine-5'-monophosphate dehydrogenase 1 isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3ZLZ7.1 GenPept UniProtKB/Swiss-Prot:D3ZLZ7

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