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Lpin3 lipin 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 362261, updated on 3-Apr-2024

Summary

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Official Symbol
Lpin3provided by RGD
Official Full Name
lipin 3provided by RGD
Primary source
RGD:1588534
See related
Ensembl:ENSRNOG00000016636 AllianceGenome:RGD:1588534
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphatidate phosphatase activity and transcription coactivator activity. Predicted to be involved in several processes, including cellular response to insulin stimulus; fatty acid catabolic process; and triglyceride biosynthetic process. Predicted to be active in nucleus. Orthologous to human LPIN3 (lipin 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 71.5), Kidney (RPKM 67.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q42
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (169953479..169978034)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (149533719..149558494)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (156874805..156899601)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene DNA topoisomerase I Neighboring gene uncharacterized LOC102551164 Neighboring gene phospholipase C, gamma 1 Neighboring gene zinc fingers and homeoboxes 3 Neighboring gene uncharacterized LOC134486198 Neighboring gene elastin microfibril interfacer 3 Neighboring gene uncharacterized LOC134486200 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene chromodomain helicase DNA binding protein 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Differential regulation of the expressions of the PGC-1α splice variants, lipins, and PPARα in heart compared to liver. Kok BPC, et al. J Lipid Res, 2013 Jun. PMID 23505321, Free PMC Article
  2. Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns. Donkor J, et al. J Biol Chem, 2007 Feb 9. PMID 17158099
  3. Temporal and spatial regulation of the phosphatidate phosphatases lipin 1 and 2. Grimsey N, et al. J Biol Chem, 2008 Oct 24. PMID 18694939, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC109016

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidate phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cellular response to insulin stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphatidate phosphatase LPIN3
NP_001014206.1
XP_006235549.1
XP_006235555.1
XP_038961442.1
XP_038961443.1
XP_038961444.1
XP_038961445.1
XP_038961447.1
XP_038961449.1
XP_063140260.1
XP_063140262.1
XP_063140263.1
XP_063140264.1
XP_063140265.1
XP_063140266.1
XP_063140267.1
XP_063140268.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014184.1 → NP_001014206.1  phosphatidate phosphatase LPIN3

    See identical proteins and their annotated locations for NP_001014206.1

    Status: PROVISIONAL

    Source sequence(s)
    BC089878
    UniProtKB/TrEMBL
    A0A8J8YGA4, F1LMI0, Q5EBA5
    Conserved Domains (3) summary
    pfam04571
    Location:1 → 106
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:585 → 810
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:431 → 521
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    169953479..169978034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063284190.1 → XP_063140260.1  phosphatidate phosphatase LPIN3 isoform X1

  2. XM_039105515.2 → XP_038961443.1  phosphatidate phosphatase LPIN3 isoform X1

    UniProtKB/TrEMBL
    A0A8J8YGA4
    Conserved Domains (3) summary
    pfam04571
    Location:1 → 107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:586 → 811
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:432 → 523
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

  3. XM_039105519.2 → XP_038961447.1  phosphatidate phosphatase LPIN3 isoform X1

    UniProtKB/TrEMBL
    A0A8J8YGA4
    Conserved Domains (3) summary
    pfam04571
    Location:1 → 107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:586 → 811
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:432 → 523
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

  4. XM_039105521.2 → XP_038961449.1  phosphatidate phosphatase LPIN3 isoform X1

    UniProtKB/TrEMBL
    A0A8J8YGA4
    Conserved Domains (3) summary
    pfam04571
    Location:1 → 107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:586 → 811
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:432 → 523
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

  5. XM_063284193.1 → XP_063140263.1  phosphatidate phosphatase LPIN3 isoform X2

    UniProtKB/TrEMBL
    F1LMI0, Q5EBA5

  6. XM_063284197.1 → XP_063140267.1  phosphatidate phosphatase LPIN3 isoform X2

    UniProtKB/TrEMBL
    F1LMI0, Q5EBA5

  7. XM_006235493.5 → XP_006235555.1  phosphatidate phosphatase LPIN3 isoform X2

    See identical proteins and their annotated locations for XP_006235555.1

    UniProtKB/TrEMBL
    A0A8J8YGA4, F1LMI0, Q5EBA5
    Conserved Domains (3) summary
    pfam04571
    Location:1 → 106
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:585 → 810
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:431 → 521
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

  8. XM_039105517.2 → XP_038961445.1  phosphatidate phosphatase LPIN3 isoform X1

    UniProtKB/TrEMBL
    A0A8J8YGA4
    Conserved Domains (3) summary
    pfam04571
    Location:1 → 107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:586 → 811
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:432 → 523
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

  9. XM_063284195.1 → XP_063140265.1  phosphatidate phosphatase LPIN3 isoform X2

    UniProtKB/TrEMBL
    F1LMI0, Q5EBA5

  10. XM_063284192.1 → XP_063140262.1  phosphatidate phosphatase LPIN3 isoform X1

  11. XM_063284196.1 → XP_063140266.1  phosphatidate phosphatase LPIN3 isoform X2

    UniProtKB/TrEMBL
    F1LMI0, Q5EBA5

  12. XM_063284198.1 → XP_063140268.1  phosphatidate phosphatase LPIN3 isoform X3

  13. XM_039105516.2 → XP_038961444.1  phosphatidate phosphatase LPIN3 isoform X1

    UniProtKB/TrEMBL
    A0A8J8YGA4
    Conserved Domains (3) summary
    pfam04571
    Location:1 → 107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:586 → 811
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:432 → 523
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

  14. XM_039105514.2 → XP_038961442.1  phosphatidate phosphatase LPIN3 isoform X1

    UniProtKB/TrEMBL
    A0A8J8YGA4
    Conserved Domains (3) summary
    pfam04571
    Location:1 → 107
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:586 → 811
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:432 → 523
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

  15. XM_063284194.1 → XP_063140264.1  phosphatidate phosphatase LPIN3 isoform X2

    UniProtKB/TrEMBL
    F1LMI0, Q5EBA5

  16. XM_006235487.5 → XP_006235549.1  phosphatidate phosphatase LPIN3 isoform X2

    See identical proteins and their annotated locations for XP_006235549.1

    UniProtKB/TrEMBL
    A0A8J8YGA4, F1LMI0, Q5EBA5
    Related
    ENSRNOP00000096250.1
    Conserved Domains (3) summary
    pfam04571
    Location:1 → 106
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:585 → 810
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:431 → 521
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

RNA

  1. XR_010064668.1 RNA Sequence

  2. XR_010064667.1 RNA Sequence

  3. XR_010064666.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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