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Rps6kb2 ribosomal protein S6 kinase B2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361696, updated on 11-Apr-2024

Summary

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Official Symbol
Rps6kb2provided by RGD
Official Full Name
ribosomal protein S6 kinase B2provided by RGD
Primary source
RGD:1305144
See related
Ensembl:ENSRNOG00000021689 AllianceGenome:RGD:1305144
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables ATP binding activity; peptide binding activity; and ribosomal protein S6 kinase activity. Involved in protein phosphorylation. Predicted to be located in ribosome. Predicted to be active in cytoplasm and nucleus. Orthologous to human RPS6KB2 (ribosomal protein S6 kinase B2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 101.7), Lung (RPKM 72.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q43
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (210880824..210887556, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (201451265..201458096, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (219406201..219412888, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene coronin 1B Neighboring gene protein tyrosine phosphatase, receptor type, C-associated protein Neighboring gene carnosine synthase 1 Neighboring gene TBC1 domain family, member 10C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Lean and obese Zucker rats exhibit different patterns of p70s6 kinase regulation in the tibialis anterior muscle in response to high-force muscle contraction. Katta A, et al. Muscle Nerve, 2009 Apr. PMID 19296503, Free PMC Article
  2. Cross-talk between the ERK and p70 S6 kinase (S6K) signaling pathways. MEK-dependent activation of S6K2 in cardiomyocytes. Wang L, et al. J Biol Chem, 2001 Aug 31. PMID 11431469
  3. The Coffin-Lowry syndrome-associated protein RSK2 controls neuroendocrine secretion through the regulation of phospholipase D1 at the exocytotic sites. Zeniou-Meyer M, et al. Ann N Y Acad Sci, 2009 Jan. PMID 19161391
  4. The Coffin-Lowry syndrome-associated protein RSK2 is implicated in calcium-regulated exocytosis through the regulation of PLD1. Zeniou-Meyer M, et al. Proc Natl Acad Sci U S A, 2008 Jun 17. PMID 18550821, Free PMC Article
  5. The effect of MK-801 on mTOR/p70S6K and translation-related proteins in rat frontal cortex. Yoon SC, et al. Neurosci Lett, 2008 Mar 21. PMID 18262357

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. insulin resistance is associated with alterations in the ability of muscle to activate p70S6k signaling following an acute bout of exercise
    Title: Lean and obese Zucker rats exhibit different patterns of p70s6 kinase regulation in the tibialis anterior muscle in response to high-force muscle contraction.
  2. RSK2 is a critical upstream signaling element in the activation of PLD1 to produce the lipids required for exocytosis
    Title: The Coffin-Lowry syndrome-associated protein RSK2 controls neuroendocrine secretion through the regulation of phospholipase D1 at the exocytotic sites.
  3. RSK2 is an essential modulator of PLD1 activity in calcium-regulated exocytosis.
    Title: The Coffin-Lowry syndrome-associated protein RSK2 is implicated in calcium-regulated exocytosis through the regulation of PLD1.
  4. Thus, proteins in the mTOR/p70S6K pathway are modulated in chronic MK-801 animal models.
    Title: The effect of MK-801 on mTOR/p70S6K and translation-related proteins in rat frontal cortex.
  5. phosphorylation of p70(s6k), likely via the Insulin-Like Growth Factor I pathway, may play an important role in androgen-induced skeletal muscle hypertrophy
    Title: Phosphorylation of p70s6 kinase is implicated in androgen-induced levator ani muscle anabolism in castrated rats.
  6. p122RhoGAP Ser-322 acts as an integrator of signal transduction in a manner dependent on the cellular context and is a substrate for protein kinase B and ribosomal S6 kinase
    Title: Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells.
  7. PKCalpha is implicated in CCK-induced activation of p70 S6 kinase in pancreatic acinar AR42J cells.
    Title: Protein kinase Calpha is implicated in cholecystokinin-induced activation of 70-kd S6 kinase in AR42J cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables ribosomal protein S6 kinase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in TOR signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of translational initiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ribosomal protein S6 kinase beta-2
Names
ribosomal protein S6 kinase, 70kDa, polypeptide 2
ribosomal protein S6 kinase, polypeptide 2
NP_001010962.2
XP_038939718.1
XP_038939724.1
XP_063124245.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001010962.2 → NP_001010962.2  ribosomal protein S6 kinase beta-2

    See identical proteins and their annotated locations for NP_001010962.2

    Status: VALIDATED

    Source sequence(s)
    AW144793, CK843568, DY315655, DY561917
    UniProtKB/TrEMBL
    A6HYU9, D4AE24
    Related
    ENSRNOP00000029993.5, ENSRNOT00000029580.6
    Conserved Domains (1) summary
    cd05584
    Location:70 → 392
    STKc_p70S6K; Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    210880824..210887556 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063268175.1 → XP_063124245.1  ribosomal protein S6 kinase beta-2 isoform X1

  2. XM_039083796.2 → XP_038939724.1  ribosomal protein S6 kinase beta-2 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:1 → 192
    PKc_like; Protein Kinases, catalytic domain

  3. XM_039083790.2 → XP_038939718.1  ribosomal protein S6 kinase beta-2 isoform X2

    Conserved Domains (1) summary
    cl21453
    Location:1 → 192
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. XR_005488929.2 RNA Sequence

  2. XR_005488930.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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