Pik3c2a phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pik3c2aprovided by RGD
Official Full Name: phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alphaprovided by RGD
Primary source: RGD:1310389
See related: Ensembl:ENSRNOG00000020479 AllianceGenome:RGD:1310389
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable clathrin binding activity and phosphatidylinositol 3-kinase activity. Predicted to be involved in several processes, including phosphatidylinositol 3-kinase signaling; phosphatidylinositol-3-phosphate biosynthetic process; and positive regulation of cell migration involved in sprouting angiogenesis. Predicted to act upstream of or within autophagosome organization; cellular response to starvation; and negative regulation of zinc ion transmembrane transport. Predicted to be located in several cellular components, including clathrin-coated vesicle; nucleoplasm; and trans-Golgi network. Predicted to be part of phosphatidylinositol 3-kinase complex. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 203.7), Lung (RPKM 188.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q35

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (180012248..180117786, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (170577942..170684353, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (185210922..185326314)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

C/EBPalpha-Mediated Transcriptional Activation of PIK3C2A Regulates Autophagy, Matrix Metalloproteinase Expression, and Phenotypic of Vascular Smooth Muscle Cells in Aortic Dissection.
Title: C/EBPα-Mediated Transcriptional Activation of PIK3C2A Regulates Autophagy, Matrix Metalloproteinase Expression, and Phenotypic of Vascular Smooth Muscle Cells in Aortic Dissection.
Anti-apoptotic Effect of MiR-223-3p Suppressing PIK3C2A in Cardiomyocytes from Myocardial Infarction Rat Through Regulating PI3K/Akt Signaling Pathway.
Title: Anti-apoptotic Effect of MiR-223-3p Suppressing PIK3C2A in Cardiomyocytes from Myocardial Infarction Rat Through Regulating PI3K/Akt Signaling Pathway.
PI3K-C2alpha and its product PtdIns(3,4)P2 may play roles in the secretory process.
Title: Involvement of class II phosphoinositide 3-kinase α-isoform in antigen-induced degranulation in RBL-2H3 cells.
The role of PI3K-C2alpha in Ca2+-dependent Rho-mediated negative control of myosin phosphatase and thus vascular smooth muscle contraction is reported.
Title: Class II phosphoinositide 3-kinase alpha-isoform regulates Rho, myosin phosphatase and contraction in vascular smooth muscle.
PI3K-C2alpha is necessary for Ca2+-induced Rho- and Rho kinase-dependent negative regulation of MLCP and consequently MLC phosphorylation and contraction.
Title: Essential role for class II phosphoinositide 3-kinase alpha-isoform in Ca2+-induced, Rho- and Rho kinase-dependent regulation of myosin phosphatase and contraction in isolated vascular smooth muscle cells.

Submit: New GeneRIF Correction

General gene information

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Markers

BM387076 (e-PCR)
- UniSTS:261250

AI236381 (e-PCR)
- UniSTS:250518

RH140296 (e-PCR)
- UniSTS:222374

RH136965 (e-PCR)
- UniSTS:219054

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-3-kinase activity	ISO Inferred from Sequence Orthology more info
enables 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity	ISO Inferred from Sequence Orthology more info
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables clathrin binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within autophagosome organization	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cellular response to starvation	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	ISO Inferred from Sequence Orthology more info
involved_in endocytosis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within macroautophagy	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of zinc ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphatidylinositol-3-phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in clathrin-coated vesicle	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of phosphatidylinositol 3-kinase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

Names: phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide; phosphoinositide-3-kinase, class 2, alpha polypeptide

NP_001101970.1

EC 2.7.1.154

XP_038938729.1

EC 2.7.1.154

XP_063123573.1

EC 2.7.1.154

XP_063123577.1

EC 2.7.1.154

XP_063123580.1

EC 2.7.1.154

XP_063123582.1

EC 2.7.1.154

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108500.1 → NP_001101970.1 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

See identical proteins and their annotated locations for NP_001101970.1

Status: PROVISIONAL

Source sequence(s)

CH473956

UniProtKB/TrEMBL

A6I8E5, D3ZTF6

Related

ENSRNOP00000051993.2, ENSRNOT00000055120.3

Conserved Domains (6) summary

cd07289
Location:1427 → 1535

PX_PI3K_C2_alpha; The phosphoinositide binding Phox Homology Domain of the Alpha Isoform of Class II Phosphoinositide 3-Kinases

cd04012
Location:678 → 850

C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cd08381
Location:1561 → 1682

C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cd00869
Location:871 → 1039

PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...

cd05176
Location:1044 → 1396

PI3Kc_C2_alpha; Catalytic domain of Class II Phosphoinositide 3-kinase alpha

pfam00794
Location:411 → 514

PI3K_rbd; PI3-kinase family, ras-binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

180012248..180117786 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063267507.1 → XP_063123577.1 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X2
XM_063267503.1 → XP_063123573.1 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X1

UniProtKB/TrEMBL

A6I8E5, D3ZTF6
XM_063267510.1 → XP_063123580.1 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X3

UniProtKB/TrEMBL

A6I8E7
XM_063267512.1 → XP_063123582.1 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X4
XM_039082801.2 → XP_038938729.1 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha isoform X5

Conserved Domains (4) summary

cd04012
Location:678 → 850

C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cd00869
Location:871 → 1039

PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...

pfam00794
Location:421 → 514

PI3K_rbd; PI3-kinase family, ras-binding domain

cl21453
Location:1044 → 1139

PKc_like; Protein Kinases, catalytic domain