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Echdc1 ethylmalonyl-CoA decarboxylase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361465, updated on 9-Apr-2024

Summary

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Official Symbol
Echdc1provided by RGD
Official Full Name
ethylmalonyl-CoA decarboxylase 1provided by RGD
Primary source
RGD:1359654
See related
Ensembl:ENSRNOG00000011622 AllianceGenome:RGD:1359654
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
MMCD
Summary
Predicted to enable carboxy-lyase activity and enoyl-CoA hydratase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to be active in cytosol. Orthologous to human ECHDC1 (ethylmalonyl-CoA decarboxylase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 127.4), Adrenal (RPKM 90.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1p11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (30304968..30355957, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (28476354..28507173, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (30874410..30921117, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1, pseudogene 23 Neighboring gene ring finger protein 146 Neighboring gene liver enriched gene 1, pseudogene 1 Neighboring gene ADP-ribosylation factor 1, pseudogene 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Ethylmalonyl-CoA decarboxylase, a new enzyme involved in metabolite proofreading. Linster CL, et al. J Biol Chem, 2011 Dec 16. PMID 22016388, Free PMC Article
  2. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC93992

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carboxy-lyase activity ISO
Inferred from Sequence Orthology
more info
  
enables carboxy-lyase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables methyl/ethyl malonyl-CoA decarboxylase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid beta-oxidation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ethylmalonyl-CoA decarboxylase
Names
enoyl CoA hydratase domain containing 1
enoyl Coenzyme A hydratase domain containing 1
enoyl-CoA hydratase domain-containing protein 1
methylmalonyl-CoA decarboxylase
NP_001007735.1
XP_006227808.3
XP_006227809.1
XP_063122135.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007734.1 → NP_001007735.1  ethylmalonyl-CoA decarboxylase isoform 1

    See identical proteins and their annotated locations for NP_001007735.1

    Status: PROVISIONAL

    Source sequence(s)
    BC079052
    UniProtKB/Swiss-Prot
    Q6AYG5
    UniProtKB/TrEMBL
    A0A8L2UIU5, A6JUT5
    Related
    ENSRNOP00000015440.4, ENSRNOT00000015440.5
    Conserved Domains (1) summary
    cd06558
    Location:52 → 243
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

  2. NM_001429129.1 → NP_001416058.1  ethylmalonyl-CoA decarboxylase isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

  3. NM_001429130.1 → NP_001416059.1  ethylmalonyl-CoA decarboxylase isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

  4. NM_001429131.1 → NP_001416060.1  ethylmalonyl-CoA decarboxylase isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    30304968..30355957 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006227746.4 → XP_006227808.3  ethylmalonyl-CoA decarboxylase isoform X1

    UniProtKB/TrEMBL
    A0A8I6AT16

  2. XM_006227747.5 → XP_006227809.1  ethylmalonyl-CoA decarboxylase isoform X3

    UniProtKB/Swiss-Prot
    Q6AYG5
    UniProtKB/TrEMBL
    A0A8L2UIU5, A6JUT5
    Conserved Domains (1) summary
    cd06558
    Location:52 → 243
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

  3. XM_063266065.1 → XP_063122135.1  ethylmalonyl-CoA decarboxylase isoform X2

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AYG5.1 GenPept UniProtKB/Swiss-Prot:Q6AYG5

Gene LinkOut

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