Akap7 A-kinase anchoring protein 7 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Akap7provided by RGD
Official Full Name: A-kinase anchoring protein 7provided by RGD
Primary source: RGD:1303071
See related: Ensembl:ENSRNOG00000013202 AllianceGenome:RGD:1303071
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Akap15; Akap18; AKAP-18; AKAP18d
Summary: Enables several functions, including AMP binding activity; protein C-terminus binding activity; and protein kinase A regulatory subunit binding activity. Involved in regulation of protein kinase A signaling. Located in several cellular components, including T-tubule; apical plasma membrane; and sarcoplasmic reticulum. Part of protein-containing complex. Orthologous to human AKAP7 (A-kinase anchoring protein 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 87.3), Lung (RPKM 81.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1p12

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (21906503..22168663)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (20087190..20217799)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (21129213..21263850)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AKAP18delta Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR.
Title: AKAP18δ Anchors and Regulates CaMKII Activity at Phospholamban-SERCA2 and RYR.
Report coupling of cardiac Kir2.1 and Kir2.2 subunits with the plasma membrane-bound AKAPs 15 and 79. Cardiac membrane-associated AKAPs are a functionally essential part of the regulatory cascade determining IK1 current function.
Title: Role of plasma membrane-associated AKAPs for the regulation of cardiac I(K1) current by protein kinase A.
results confirm that AKAP7gamma/delta binding to PLB is important for phosphorylation of PLB.
Title: Phosphorylation state-dependent interaction between AKAP7δ/γ and phospholamban increases phospholamban phosphorylation.
The roles of AKAP 18 alpha and gamma in mediating insulin release are consistent with their respective regulations by glucose.
Title: AKAP 18 alpha and gamma have opposing effects on insulin release in INS-1E cells.
Akap18 contains a phosphodiesterase domain that binds AMP.
Title: AKAP18 contains a phosphoesterase domain that binds AMP.
Data show that AKAP18delta acts as a scaffold that coordinates PKA phosphorylation of PLN and the adrenergic effect on Ca(2+) re-uptake.
Title: AKAP complex regulates Ca2+ re-uptake into heart sarcoplasmic reticulum.
mainly expressed in principal cells of the inner medullary collecting duct, closely resembling the distribution of aquaporin-2; data suggest that AKAP18delta is involved in the aquaporin-2 shuttle
Title: Identification of a novel A-kinase anchoring protein 18 isoform and evidence for its role in the vasopressin-induced aquaporin-2 shuttle in renal principal cells.
Beta-adrenergic regulation requires direct anchoring of protein kinase A to cardiac CaV1.2 channels via a leucine zipper interaction with protein kinase A-anchoring protein 15(AKAP15).
Title: Beta-adrenergic regulation requires direct anchoring of PKA to cardiac CaV1.2 channels via a leucine zipper interaction with A kinase-anchoring protein 15.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH137836 (e-PCR)
- UniSTS:219923

RH139240 (e-PCR)
- UniSTS:221326

D1Rat479 (e-PCR), detects polymorphism
- UniSTS:227261

RH134040 (e-PCR)
- UniSTS:217322

PMC22491P1 (e-PCR)
- UniSTS:272112

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables AMP binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A binding	IEA Inferred from Electronic Annotation more info
enables protein kinase A binding	ISO Inferred from Sequence Orthology more info
enables protein kinase A binding	TAS Traceable Author Statement more info	PubMed
enables protein kinase A regulatory subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase A regulatory subunit binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase A regulatory subunit binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of potassium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in regulation of membrane repolarization	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein kinase A signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of protein kinase A signaling	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in exocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in hippocampal mossy fiber to CA3 synapse	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: A-kinase anchor protein 7 isoforms delta and gamma

Names: A kinase (PRKA) anchor protein 7; A-kinase anchor protein 18; A-kinase anchoring protein 18 ,isoform delta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001001801.4 → NP_001001801.1 A-kinase anchor protein 7 isoforms delta and gamma

See identical proteins and their annotated locations for NP_001001801.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

D3ZMQ5, Q6JP77

UniProtKB/TrEMBL

A0A0A0MXX1

Related

ENSRNOP00000084444.1, ENSRNOT00000096819.1

Conserved Domains (2) summary

pfam10470
Location:295 → 350

AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein

pfam10469
Location:90 → 288

AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

21906503..22168663

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039081134.2 → XP_038937062.1 A-kinase anchor protein 7 isoforms delta and gamma isoform X2

Conserved Domains (1) summary

pfam10469
Location:126 → 275

AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
XM_039081121.2 → XP_038937049.1 A-kinase anchor protein 7 isoforms delta and gamma isoform X1

UniProtKB/TrEMBL

A0A8I5ZX86

Conserved Domains (1) summary

pfam10469
Location:126 → 324

AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
XM_063266032.1 → XP_063122102.1 A-kinase anchor protein 7 isoforms delta and gamma isoform X3
XM_039081154.2 → XP_038937082.1 A-kinase anchor protein 7 isoforms delta and gamma isoform X4

Conserved Domains (2) summary

pfam10470
Location:171 → 226

AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein

pfam10469
Location:6 → 164

AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
XM_039081160.2 → XP_038937088.1 A-kinase anchor protein 7 isoforms delta and gamma isoform X5

Conserved Domains (1) summary

pfam10470
Location:23 → 79

AKAP7_RIRII_bdg; PKA-RI-RII subunit binding domain of A-kinase anchor protein