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Adgre5 adhesion G protein-coupled receptor E5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 361383, updated on 11-Apr-2024

Summary

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Official Symbol
Adgre5provided by RGD
Official Full Name
adhesion G protein-coupled receptor E5provided by RGD
Primary source
RGD:1305595
See related
Ensembl:ENSRNOG00000004489 AllianceGenome:RGD:1305595
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Cd97
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within positive regulation of synapse assembly. Predicted to be located in external side of plasma membrane. Predicted to be integral component of plasma membrane. Human ortholog(s) of this gene implicated in vibratory urticaria. Orthologous to several human genes including ADGRE5 (adhesion G protein-coupled receptor E5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 659.8), Spleen (RPKM 245.2) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
19q11
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (41302687..41332183)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (24397972..24418648)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (24854981..24875712, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483629 Neighboring gene uncharacterized LOC134483630 Neighboring gene uncharacterized LOC134483332 Neighboring gene transfer RNA alanine (anticodon AGC) 20 Neighboring gene DExD-box helicase 39A Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120098561 Neighboring gene protein kinase N1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. CD97, but not its closely related EGF-TM7 family member EMR2, is expressed on gastric, pancreatic, and esophageal carcinomas. Aust G, et al. Am J Clin Pathol, 2002 Nov. PMID 12428789
  2. Complement factor H, a marker of self protects against experimental autoimmune encephalomyelitis. Griffiths MR, et al. J Immunol, 2009 Apr 1. PMID 19299737
  3. Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins. Um JW, et al. Cell Rep, 2014 Mar 27. PMID 24613359, Free PMC Article
  4. Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation. Kuo JC, et al. Nat Cell Biol, 2011 Apr. PMID 21423176, Free PMC Article
  5. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. Buschow SI, et al. Immunol Cell Biol, 2010 Nov-Dec. PMID 20458337

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of synapse assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
adhesion G protein-coupled receptor E5
Names
CD97 antigen
CD97 molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012164.1 → NP_001012164.1  adhesion G protein-coupled receptor E5 precursor

    See identical proteins and their annotated locations for NP_001012164.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083857
    UniProtKB/TrEMBL
    A0A8I6G2Z6, E9PT32, Q5XI36
    Related
    ENSRNOP00000079224.1, ENSRNOT00000117374.1
    Conserved Domains (4) summary
    smart00179
    Location:69 → 101
    EGF_CA; Calcium-binding EGF-like domain
    pfam00002
    Location:534 → 773
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam01825
    Location:487 → 526
    GPS; GPCR proteolysis site, GPS, motif
    pfam07645
    Location:171 → 218
    EGF_CA; Calcium-binding EGF domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    41302687..41332183
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063278115.1 → XP_063134185.1  adhesion G protein-coupled receptor E5 isoform X3

  2. XM_063278116.1 → XP_063134186.1  adhesion G protein-coupled receptor E5 isoform X6

  3. XM_063278114.1 → XP_063134184.1  adhesion G protein-coupled receptor E5 isoform X1

  4. XM_006255278.4 → XP_006255340.3  adhesion G protein-coupled receptor E5 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JSI4

  5. XM_006255279.4 → XP_006255341.3  adhesion G protein-coupled receptor E5 isoform X4

  6. XM_006255281.4 → XP_006255343.3  adhesion G protein-coupled receptor E5 isoform X5

Nucleotide Protein Strain
Heading Accession and Version

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