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Phkb phosphorylase kinase regulatory subunit beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 361377, updated on 13-Apr-2024

Summary

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Official Symbol
Phkbprovided by RGD
Official Full Name
phosphorylase kinase regulatory subunit betaprovided by RGD
Primary source
RGD:620186
See related
Ensembl:ENSRNOG00000024101 AllianceGenome:RGD:620186
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calmodulin binding activity and kinase activity. Involved in protein phosphorylation. Part of phosphorylase kinase complex. Human ortholog(s) of this gene implicated in glycogen storage disease IXb. Orthologous to human PHKB (phosphorylase kinase regulatory subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 843.9), Heart (RPKM 144.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Phkb in Genome Data Viewer
Location:
19p11
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (37179937..37383979, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (21013719..21210671, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (22031684..22281788, complement)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120098533 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene integrin alpha FG-GAP repeat containing 1 Neighboring gene uncharacterized LOC134483303

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The alpha and beta subunits of phosphorylase kinase are homologous: cDNA cloning and primary structure of the beta subunit. Kilimann MW, et al. Proc Natl Acad Sci U S A, 1988 Dec. PMID 3200826, Free PMC Article
  2. Coordinated expression of phosphorylase kinase subunits in regenerating skeletal muscle. Cawley KC, et al. J Biol Chem, 1992 Aug 25. PMID 1512265
  3. Purification of rat liver phosphorylase kinase. Chrisman TD, et al. J Biol Chem, 1982 Sep 25. PMID 6809757
  4. Rat skeletal muscle phosphorylase kinase: turnover and control of isozyme levels in culture. Salsgiver WJ, et al. Am J Physiol, 1986 Mar. PMID 3953807
  5. Phosphorylase kinase: the complexity of its regulation is reflected in the complexity of its structure. Brushia RJ, et al. Front Biosci, 1999 Sep 15. PMID 10487978

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycogen metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of phosphorylase kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of phosphorylase kinase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphorylase b kinase regulatory subunit beta
Names
phosphorylase kinase beta subunit
phosphorylase kinase, beta
NP_001014174.1
NP_001401861.1
NP_001401862.1
NP_001401863.1
XP_063134180.1
XP_063134181.1
XP_063134182.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014152.1 → NP_001014174.1  phosphorylase b kinase regulatory subunit beta isoform 4

    See identical proteins and their annotated locations for NP_001014174.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085909
    UniProtKB/TrEMBL
    A0A8I5Y5Q0, F1LNP9, Q5RKH5
    Conserved Domains (1) summary
    pfam00723
    Location:49 → 349
    Glyco_hydro_15; Glycosyl hydrolases family 15

  2. NM_001414932.1 → NP_001401861.1  phosphorylase b kinase regulatory subunit beta isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A0A8J8YFM3
    Related
    ENSRNOP00000039778.5, ENSRNOT00000049624.5

  3. NM_001414933.1 → NP_001401862.1  phosphorylase b kinase regulatory subunit beta isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019

  4. NM_001414934.1 → NP_001401863.1  phosphorylase b kinase regulatory subunit beta isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A6KDC6
    Related
    ENSRNOP00000083595.1, ENSRNOT00000110468.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    37179937..37383979 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063278111.1 → XP_063134181.1  phosphorylase b kinase regulatory subunit beta isoform X2

  2. XM_063278110.1 → XP_063134180.1  phosphorylase b kinase regulatory subunit beta isoform X1

  3. XM_063278112.1 → XP_063134182.1  phosphorylase b kinase regulatory subunit beta isoform X3

RNA

  1. XR_010060011.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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