Sucla2 succinate-CoA ligase ADP-forming subunit beta [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sucla2provided by RGD
Official Full Name: succinate-CoA ligase ADP-forming subunit betaprovided by RGD
Primary source: RGD:1309397
See related: Ensembl:ENSRNOG00000017481 AllianceGenome:RGD:1309397
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables succinate-CoA ligase (ADP-forming) activity. Involved in succinate metabolic process; succinyl-CoA metabolic process; and tricarboxylic acid cycle. Located in mitochondrion. Human ortholog(s) of this gene implicated in mitochondrial DNA depletion syndrome 5. Orthologous to human SUCLA2 (succinate-CoA ligase ADP-forming subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 1579.2), Heart (RPKM 1529.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15q11

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (55161894..55215031)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (48752356..48805495)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (55461695..55516954)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In INS-1 832/13 cells and cultured rat islets, siRNA suppression of the ATP-producing isoform increased Glucose-stimulated insulin secretion by 2-fold.
Title: Mitochondrial GTP regulates glucose-stimulated insulin secretion.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH139628 (e-PCR)
- UniSTS:221712

BE101893 (e-PCR)
- UniSTS:243761

Sucla2 (e-PCR), detects polymorphism
- UniSTS:507251

RH141159 (e-PCR)
- UniSTS:223155

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables succinate-CoA ligase (ADP-forming) activity	IBA Inferred from Biological aspect of Ancestor more info
enables succinate-CoA ligase (ADP-forming) activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in succinate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in succinyl-CoA metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in succinyl-CoA metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in tricarboxylic acid cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in tricarboxylic acid cycle	IDA Inferred from Direct Assay more info	PubMed
involved_in tricarboxylic acid cycle	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
part_of succinate-CoA ligase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of succinate-CoA ligase complex (ADP-forming)	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

Names: succinate-CoA ligase ADP-forming beta subunit; succinate-CoA ligase beta subunit; succinate-Coenzyme A ligase, ADP-forming, beta subunit; succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial

NP_001101857.2

EC 6.2.1.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108387.2 → NP_001101857.2 succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

Status: VALIDATED

Source sequence(s)

BF408124, BF412750, CF110427, CO399305, CR755094

UniProtKB/TrEMBL

B2RZ24, F1LM47

Related

ENSRNOP00000060229.1, ENSRNOT00000065195.4

Conserved Domains (1) summary

PRK00696
Location:57 → 447

sucC; ADP-forming succinate--CoA ligase subunit beta