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Ncor2 nuclear receptor co-repressor 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 360801, updated on 11-Apr-2024

Summary

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Official Symbol
Ncor2provided by RGD
Official Full Name
nuclear receptor co-repressor 2provided by RGD
Primary source
RGD:1310293
See related
Ensembl:ENSRNOG00000001004 AllianceGenome:RGD:1310293
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables chromatin binding activity; glucocorticoid receptor binding activity; and retinoid X receptor binding activity. Involved in several processes, including estrous cycle; lactation; and response to estradiol. Located in chromatin and nucleus. Human ortholog(s) of this gene implicated in osteoarthritis. Orthologous to human NCOR2 (nuclear receptor corepressor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 91.5), Spleen (RPKM 47.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
12q15
Exon count:
51
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (37127736..37289612)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (31466418..31628319)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (36871917..37033701)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134481291 Neighboring gene scavenger receptor class B, member 1 Neighboring gene uncharacterized LOC120095963 Neighboring gene uncharacterized LOC120095965 Neighboring gene refilin A Neighboring gene zinc finger protein 664 Neighboring gene ribosomal protein L27 like 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Exchange of a nuclear corepressor between NF-kappaB and CREB mediates inhibition of phosphoenolpyruvate carboxykinase transcription by NF-kappaB. Yan JH, et al. Chin Med J (Engl), 2010 Jan 20. PMID 20137375
  2. A structural and in vitro characterization of asoprisnil: a selective progesterone receptor modulator. Madauss KP, et al. Mol Endocrinol, 2007 May. PMID 17356170
  3. Regulation of the content of progesterone and estrogen receptors, and their cofactors SRC-1 and SMRT by the 26S proteasome in the rat brain during the estrous cycle. Villamar-Cruz O, et al. Brain Res Bull, 2006 Apr 14. PMID 16564422
  4. Glucocorticoid receptor cofactors as therapeutic targets. Simons SS Jr. Curr Opin Pharmacol, 2010 Dec. PMID 20801081, Free PMC Article
  5. Nuclear corepressor is required for inhibition of phosphoenolpyruvate carboxykinase expression by tumor necrosis factor-alpha. Yan J, et al. Mol Endocrinol, 2007 Jul. PMID 17456789

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables Notch binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
  
enables nuclear glucocorticoid receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nuclear receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nuclear retinoic acid receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables nuclear retinoid X receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell proliferation in forebrain ISO
Inferred from Sequence Orthology
more info
  
involved_in cerebellum development IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in epidermis development ISO
Inferred from Sequence Orthology
more info
  
involved_in establishment of skin barrier ISO
Inferred from Sequence Orthology
more info
  
involved_in estrous cycle IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within forebrain development ISO
Inferred from Sequence Orthology
more info
  
involved_in gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glucose homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within heart morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in lactation IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of miRNA transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of protein deacetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cellular ketone metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in response to estradiol IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to organonitrogen compound IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within telencephalon development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within type I pneumocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of white fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within white fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of chromatin IDA
Inferred from Direct Assay
more info
 PubMed 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
part_of histone deacetylase complex ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear matrix ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
nuclear receptor corepressor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108334.1 → NP_001101804.1  nuclear receptor corepressor 2

    See identical proteins and their annotated locations for NP_001101804.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473973
    UniProtKB/TrEMBL
    A6J0X3, D3ZXN9
    Related
    ENSRNOP00000087552.1, ENSRNOT00000099234.1
    Conserved Domains (4) summary
    smart00717
    Location:610 → 655
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:610 → 653
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam15784
    Location:142 → 228
    GPS2_interact; G-protein pathway suppressor 2-interacting domain
    cl21498
    Location:432 → 475
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    37127736..37289612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249305.5 → XP_006249367.1  nuclear receptor corepressor 2 isoform X24

    UniProtKB/TrEMBL
    D3ZXN9
    Conserved Domains (6) summary
    PHA03247
    Location:1917 → 2321
    PHA03247; large tegument protein UL36; Provisional
    COG0419
    Location:156 → 411
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG5259
    Location:539 → 649
    RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
    pfam00249
    Location:614 → 657
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam15784
    Location:141 → 229
    GPS2_interact; G-protein pathway suppressor 2-interacting domain
    cl21498
    Location:432 → 475
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  2. XM_006249320.5 → XP_006249382.1  nuclear receptor corepressor 2 isoform X42

    UniProtKB/TrEMBL
    D3ZXN9
    Conserved Domains (4) summary
    smart00717
    Location:614 → 659
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    pfam00249
    Location:614 → 657
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam15784
    Location:142 → 228
    GPS2_interact; G-protein pathway suppressor 2-interacting domain
    cl21498
    Location:432 → 475
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  3. XM_017598397.3 → XP_017453886.1  nuclear receptor corepressor 2 isoform X44

    UniProtKB/TrEMBL
    A0A0G2JU91, D3ZXN9
    Related
    ENSRNOP00000069011.2

  4. XM_017598398.3 → XP_017453887.1  nuclear receptor corepressor 2 isoform X45

    UniProtKB/TrEMBL
    D3ZXN9

  5. XM_063271518.1 → XP_063127588.1  nuclear receptor corepressor 2 isoform X25

  6. XM_039089593.2 → XP_038945521.1  nuclear receptor corepressor 2 isoform X43

    UniProtKB/TrEMBL
    D3ZXN9
    Conserved Domains (6) summary
    PHA03247
    Location:1757 → 2258
    PHA03247; large tegument protein UL36; Provisional
    COG5259
    Location:538 → 648
    RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
    TIGR02169
    Location:159 → 404
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam00249
    Location:613 → 656
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam15784
    Location:141 → 229
    GPS2_interact; G-protein pathway suppressor 2-interacting domain
    cl21498
    Location:431 → 474
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  7. XM_039089594.2 → XP_038945522.1  nuclear receptor corepressor 2 isoform X46

    UniProtKB/TrEMBL
    A0A8I6AN60
    Conserved Domains (6) summary
    PHA03247
    Location:1757 → 2258
    PHA03247; large tegument protein UL36; Provisional
    COG5259
    Location:538 → 648
    RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
    TIGR02169
    Location:159 → 404
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam00249
    Location:613 → 656
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam15784
    Location:141 → 229
    GPS2_interact; G-protein pathway suppressor 2-interacting domain
    cl21498
    Location:431 → 474
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  8. XM_063271525.1 → XP_063127595.1  nuclear receptor corepressor 2 isoform X33

  9. XM_063271499.1 → XP_063127569.1  nuclear receptor corepressor 2 isoform X6

  10. XM_063271502.1 → XP_063127572.1  nuclear receptor corepressor 2 isoform X9

  11. XM_063271507.1 → XP_063127577.1  nuclear receptor corepressor 2 isoform X14

  12. XM_063271513.1 → XP_063127583.1  nuclear receptor corepressor 2 isoform X20

  13. XM_063271508.1 → XP_063127578.1  nuclear receptor corepressor 2 isoform X15

  14. XM_063271519.1 → XP_063127589.1  nuclear receptor corepressor 2 isoform X26

  15. XM_063271506.1 → XP_063127576.1  nuclear receptor corepressor 2 isoform X13

  16. XM_063271514.1 → XP_063127584.1  nuclear receptor corepressor 2 isoform X21

  17. XM_063271521.1 → XP_063127591.1  nuclear receptor corepressor 2 isoform X29

  18. XM_063271517.1 → XP_063127587.1  nuclear receptor corepressor 2 isoform X23

  19. XM_063271523.1 → XP_063127593.1  nuclear receptor corepressor 2 isoform X31

  20. XM_063271524.1 → XP_063127594.1  nuclear receptor corepressor 2 isoform X32

  21. XM_063271501.1 → XP_063127571.1  nuclear receptor corepressor 2 isoform X8

  22. XM_063271515.1 → XP_063127585.1  nuclear receptor corepressor 2 isoform X22

  23. XM_063271522.1 → XP_063127592.1  nuclear receptor corepressor 2 isoform X30

  24. XM_063271498.1 → XP_063127568.1  nuclear receptor corepressor 2 isoform X3

  25. XM_063271503.1 → XP_063127573.1  nuclear receptor corepressor 2 isoform X10

  26. XM_063271509.1 → XP_063127579.1  nuclear receptor corepressor 2 isoform X16

  27. XM_063271504.1 → XP_063127574.1  nuclear receptor corepressor 2 isoform X11

  28. XM_063271511.1 → XP_063127581.1  nuclear receptor corepressor 2 isoform X18

  29. XM_017598392.3 → XP_017453881.1  nuclear receptor corepressor 2 isoform X4

    UniProtKB/TrEMBL
    A0A8I6GHM0

  30. XM_063271512.1 → XP_063127582.1  nuclear receptor corepressor 2 isoform X19

  31. XM_017598396.3 → XP_017453885.1  nuclear receptor corepressor 2 isoform X28

    UniProtKB/TrEMBL
    A0A8I6GHM0

  32. XM_039089589.2 → XP_038945517.1  nuclear receptor corepressor 2 isoform X5

    UniProtKB/TrEMBL
    A0A8I6GHM0
    Conserved Domains (6) summary
    PHA03247
    Location:1741 → 2145
    PHA03247; large tegument protein UL36; Provisional
    COG5259
    Location:364 → 474
    RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
    TIGR02169
    Location:5 → 283
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam00249
    Location:439 → 482
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam15784
    Location:1 → 54
    GPS2_interact; G-protein pathway suppressor 2-interacting domain
    cl21498
    Location:257 → 300
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  33. XM_017598391.3 → XP_017453880.1  nuclear receptor corepressor 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GHM0

  34. XM_063271510.1 → XP_063127580.1  nuclear receptor corepressor 2 isoform X17

  35. XM_063271520.1 → XP_063127590.1  nuclear receptor corepressor 2 isoform X27

  36. XM_063271505.1 → XP_063127575.1  nuclear receptor corepressor 2 isoform X12

  37. XM_063271500.1 → XP_063127570.1  nuclear receptor corepressor 2 isoform X7

  38. XM_063271497.1 → XP_063127567.1  nuclear receptor corepressor 2 isoform X2

  39. XM_063271527.1 → XP_063127597.1  nuclear receptor corepressor 2 isoform X35

  40. XM_063271528.1 → XP_063127598.1  nuclear receptor corepressor 2 isoform X36

  41. XM_039089591.2 → XP_038945519.1  nuclear receptor corepressor 2 isoform X24

    UniProtKB/TrEMBL
    D3ZXN9
    Conserved Domains (6) summary
    PHA03247
    Location:1917 → 2321
    PHA03247; large tegument protein UL36; Provisional
    COG0419
    Location:156 → 411
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG5259
    Location:539 → 649
    RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
    pfam00249
    Location:614 → 657
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam15784
    Location:141 → 229
    GPS2_interact; G-protein pathway suppressor 2-interacting domain
    cl21498
    Location:432 → 475
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  42. XM_017598394.3 → XP_017453883.1  nuclear receptor corepressor 2 isoform X24

    UniProtKB/TrEMBL
    D3ZXN9
    Conserved Domains (6) summary
    PHA03247
    Location:1917 → 2321
    PHA03247; large tegument protein UL36; Provisional
    COG0419
    Location:156 → 411
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    COG5259
    Location:539 → 649
    RSC8; RSC chromatin remodeling complex subunit RSC8 [Chromatin structure and dynamics / Transcription]
    pfam00249
    Location:614 → 657
    Myb_DNA-binding; Myb-like DNA-binding domain
    pfam15784
    Location:141 → 229
    GPS2_interact; G-protein pathway suppressor 2-interacting domain
    cl21498
    Location:432 → 475
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...

  43. XM_063271526.1 → XP_063127596.1  nuclear receptor corepressor 2 isoform X34

  44. XM_039089592.2 → XP_038945520.1  nuclear receptor corepressor 2 isoform X37

    UniProtKB/TrEMBL
    A6J0X4
    Conserved Domains (2) summary
    PHA03247
    Location:1307 → 1711
    PHA03247; large tegument protein UL36; Provisional
    pfam00249
    Location:19 → 47
    Myb_DNA-binding; Myb-like DNA-binding domain

  45. XM_063271529.1 → XP_063127599.1  nuclear receptor corepressor 2 isoform X38

  46. XM_063271530.1 → XP_063127600.1  nuclear receptor corepressor 2 isoform X39

  47. XM_063271531.1 → XP_063127601.1  nuclear receptor corepressor 2 isoform X40

  48. XM_063271532.1 → XP_063127602.1  nuclear receptor corepressor 2 isoform X41

Nucleotide Protein Strain
Heading Accession and Version

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