U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hdc Histidine decarboxylase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36076, updated on 4-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Hdcprovided by FlyBase
Official Full Name
Histidine decarboxylaseprovided by FlyBase
Primary source
FLYBASE:FBgn0005619
Locus tag
Dmel_CG3454
See related
AllianceGenome:FB:FBgn0005619
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0140519.259; CG3454; Dmel\CG3454; hdc; HDC; JK910
Summary
Enables histidine decarboxylase activity. Involved in thermotaxis. Predicted to be active in cytoplasm. Is expressed in adult brain cell body rind; adult head; adult ventral nerve cord; photoreceptor cell; and retina. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome; asthma; and rhinitis. Orthologous to human HDC (histidine decarboxylase). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Hdc in Genome Data Viewer
Location:
46F7-46F7; 2-62 cM
Exon count:
10
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (10237988..10246077)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (6125493..6133582)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR46322 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Hormone receptor 3 Neighboring gene long non-coding RNA:CR45265 Neighboring gene uncharacterized protein Neighboring gene Chondroitin sulfate N-acetylgalactosaminyltransferase Neighboring gene uncharacterized protein Neighboring gene Synaptobrevin

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Microsaccadic sampling of moving image information provides Drosophila hyperacute vision. Juusola M, et al. Elife, 2017 Sep 5. PMID 28870284, Free PMC Article
  2. Fly Photoreceptors Encode Phase Congruency. Friederich U, et al. PLoS One, 2016. PMID 27336733, Free PMC Article
  3. From fruit flies to barnacles, histamine is the neurotransmitter of arthropod photoreceptors. Stuart AE. Neuron, 1999 Mar. PMID 10197524
  4. Evidence for Dynamic Network Regulation of Drosophila Photoreceptor Function from Mutants Lacking the Neurotransmitter Histamine. Dau A, et al. Front Neural Circuits, 2016. PMID 27047343, Free PMC Article
  5. Visual neurotransmission in Drosophila requires expression of Fic in glial capitate projections. Rahman M, et al. Nat Neurosci, 2012 Jun. PMID 22544313, Free PMC Article

See all (88) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables carbon-carbon lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables carboxy-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables histidine decarboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histidine decarboxylase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables histidine decarboxylase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in histamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in histidine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in thermotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
histidine decarboxylase
Names
CG3454-PA
CG3454-PB
CG3454-PC
CG3454-PD
Hdc-PA
Hdc-PB
Hdc-PC
Hdc-PD
histidine-decarboxylase
NP_001260855.1
NP_001260856.1
NP_001286274.1
NP_523679.2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    10237988..10246077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001299345.1 → NP_001286274.1  histidine decarboxylase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286274.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q05733, Q9V5I3
    UniProtKB/TrEMBL
    B6IDW5, I0B8M2
    Conserved Domains (1) summary
    pfam00282
    Location:35 → 413
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

  2. NM_001273927.2 → NP_001260856.1  histidine decarboxylase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260856.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEQ1
    Conserved Domains (1) summary
    pfam00282
    Location:35 → 413
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

  3. NM_001273926.1 → NP_001260855.1  histidine decarboxylase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260855.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q05733, Q9V5I3
    UniProtKB/TrEMBL
    B6IDW5, I0B8M2
    Conserved Domains (1) summary
    pfam00282
    Location:35 → 413
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain

  4. NM_078955.3 → NP_523679.2  histidine decarboxylase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523679.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q05733, Q9V5I3
    UniProtKB/TrEMBL
    B6IDW5, I0B8M2
    Related
    FBpp0087422
    Conserved Domains (1) summary
    pfam00282
    Location:35 → 413
    Pyridoxal_deC; Pyridoxal-dependent decarboxylase conserved domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KEQ1 A0A0B4KEQ1
I0B8M2 I0B8M2
Q05733.2 Q05733

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous