Itga3 integrin subunit alpha 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Itga3provided by RGD
Official Full Name: integrin subunit alpha 3provided by RGD
Primary source: RGD:1310333
See related: Ensembl:ENSRNOG00000004276 AllianceGenome:RGD:1310333
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including fibronectin binding activity; integrin binding activity; and laminin binding activity. Involved in several processes, including maternal process involved in female pregnancy; positive regulation of epithelial cell migration; and regulation of cell projection organization. Located in several cellular components, including cell surface; growth cone filopodium; and perinuclear region of cytoplasm. Part of integrin alpha3-beta1 complex. Biomarker of glomerulonephritis and myocardial infarction. Orthologous to human ITGA3 (integrin subunit alpha 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 231.3), Kidney (RPKM 124.6) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q26

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (80486998..80522548, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (79990160..80022206, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (82855841..82887755, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Decreased expression of Itga3, Itga6, and Itga8 in the pulmonary mesenchyme may lead to disruptions in airway branching morphogenesis, thus contributing to pulmonary hypoplasia in the nitrofen-induced congenital diaphragmatic hernia model.
Title: Decreased Expression of Integrin Subunits α3, α6, and α8 in the Branching Airway Mesenchyme of Nitrofen-Induced Hypoplastic Lungs.
formation of CD151-integrin complex was likely to be a prerequisite for CD151-induced angiogenesis and signaling pathways
Title: Role of tetraspanin CD151-α3/α6 integrin complex: Implication in angiogenesis CD151-integrin complex in angiogenesis.
Results indicate that the alpha(3) integrin receptor interacts with type VI collagen to promote myofibroblast differentiation, and that this interaction may impact in vivo post-MI remodeling.
Title: Cardiac myofibroblast differentiation is attenuated by alpha(3) integrin blockade: potential role in post-MI remodeling.
alpha3beta1 integrin is necessary for the prevention of the apoptosis of cultured rat podocytes, and the signaling involves the Bax, Bcl-2, and cytochrome c pathways
Title: Signaling and regulatory mechanisms of integrinalpha3beta1 on the apoptosis of cultured rat podocytes.
podocyte expression of alpha3- and beta1-integrin subunits is significantly reduced in humans with primary focal glomerulosclerosis and chronic puromycin-treated rats
Title: Reduced podocyte expression of alpha3beta1 integrins and podocyte depletion in patients with primary focal segmental glomerulosclerosis and chronic PAN-treated rats.
During spermatogenic cell apoptosis, integrin beta1, alpha3, and alpha6 subunits, and tetraspanins CD9 and C81 become displaced away from the developing apoptotic bodies.
Title: Role of integrins, tetraspanins, and ADAM proteins during the development of apoptotic bodies by spermatogenic cells.

Submit: New GeneRIF Correction

General gene information

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Markers

Itga3 (e-PCR), detects polymorphism
- UniSTS:143613

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables collagen binding	IDA Inferred from Direct Assay more info	PubMed
enables fibronectin binding	IDA Inferred from Direct Assay more info	PubMed
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables laminin binding	IDA Inferred from Direct Assay more info	PubMed
enables laminin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protease binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dendritic spine maintenance	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within exploration behavior	ISO Inferred from Sequence Orthology more info
NOT acts_upstream_of_or_within fusion of sperm to egg plasma membrane involved in single fertilization	ISO Inferred from Sequence Orthology more info
involved_in heart development	IEP Inferred from Expression Pattern more info	PubMed
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in leukocyte migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in lung development	ISO Inferred from Sequence Orthology more info
involved_in maternal process involved in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within memory	ISO Inferred from Sequence Orthology more info
involved_in mesodermal cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell projection organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nephron development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-substrate adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of epithelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in postsynapse organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in renal filtration	ISO Inferred from Sequence Orthology more info
involved_in response to gonadotropin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in skin development	ISO Inferred from Sequence Orthology more info
involved_in synaptic membrane adhesion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in excitatory synapse	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in filopodium membrane	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone filopodium	IDA Inferred from Direct Assay more info	PubMed
part_of integrin alpha3-beta1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of integrin alpha3-beta1 complex	ISO Inferred from Sequence Orthology more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in neuromuscular junction	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic active zone membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info
located_in synaptic membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: integrin alpha-3

Names: integrin, alpha 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108292.2 → NP_001101762.2 integrin alpha-3 isoform 1 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.

Source sequence(s)

FQ134609, JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I6GLI8, D3ZCG9

Related

ENSRNOP00000005644.3, ENSRNOT00000005644.7

Conserved Domains (2) summary

smart00191
Location:367 → 417

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:462 → 917

Integrin_alpha2; Integrin alpha
NM_001372214.1 → NP_001359143.1 integrin alpha-3 isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate exon the 3' coding region compared to variant 1. It encodes isoform 2, which has a longer and distinct C-terminus, compared to isoform 1.

Source sequence(s)

FQ134609, JAXUCZ010000010

UniProtKB/TrEMBL

D3ZQM3, I4DUB5

Related

ENSRNOP00000096579.1, ENSRNOT00000105286.1

Conserved Domains (2) summary

smart00191
Location:367 → 417

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:462 → 917

Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

80486998..80522548 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008768184.4 → XP_008766406.1 integrin alpha-3 isoform X1

See identical proteins and their annotated locations for XP_008766406.1

UniProtKB/TrEMBL

D3ZQM3, I4DUB5

Conserved Domains (2) summary

smart00191
Location:367 → 417

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:462 → 917

Integrin_alpha2; Integrin alpha