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PCB Pyruvate carboxylase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 36020, updated on 26-Apr-2024

Summary

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Official Symbol
PCBprovided by FlyBase
Official Full Name
Pyruvate carboxylaseprovided by FlyBase
Primary source
FLYBASE:FBgn0027580
Locus tag
Dmel_CG1516
See related
AllianceGenome:FB:FBgn0027580
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA; BcDNA:GH06348; CG1516; Dmel\CG1516; dPC; PC; pcb; Q0E9E2_DROME
Summary
Enables pyruvate carboxylase activity. Predicted to be involved in gluconeogenesis and pyruvate metabolic process. Located in mitochondrion. Is expressed in adult head; adult heart; and spermatozoon. Human ortholog(s) of this gene implicated in pyruvate carboxylase deficiency disease. Orthologous to human PC (pyruvate carboxylase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
46B4-46B4; 2-61 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9850703..9861543, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5738208..5749048, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Proteasome alpha7 subunit Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44293 Neighboring gene uncharacterized protein Neighboring gene pendolino Neighboring gene N-terminal methyltransferase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Glial dysfunction causes age-related memory impairment in Drosophila. Yamazaki D, et al. Neuron, 2014 Nov 19. PMID 25447741
  2. Biotin controls intestinal stem cell mitosis and host-microbiome interactions. Neophytou C, et al. Cell Rep, 2022 Mar 8. PMID 35263602
  3. Xenobiotic mediated diabetogenesis: Developmental exposure to dichlorvos or atrazine leads to type 1 or type 2 diabetes in Drosophila. Gupta HP, et al. Free Radic Biol Med, 2019 Sep. PMID 31319158
  4. Susceptibility to heat stress and aberrant gene expression patterns in holocarboxylase synthetase-deficient Drosophila melanogaster are caused by decreased biotinylation of histones, not of carboxylases. Camporeale G, et al. J Nutr, 2007 Apr. PMID 17374649, Free PMC Article
  5. [LTR retrotransposons as a source of promoters in the Drosophila genome]. Makunin IV, et al. Genetika, 2010 Sep. PMID 21061618

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables pyruvate carboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyruvate carboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyruvate carboxylase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gluconeogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in pyruvate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyruvate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyruvate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
pyruvate carboxylase
Names
CG1516-PA
CG1516-PB
CG1516-PD
CG1516-PE
CG1516-PG
CG1516-PI
CG1516-PJ
CG1516-PK
CG1516-PL
CG1516-PM
GH06348
PCB-PA
PCB-PB
PCB-PD
PCB-PE
PCB-PG
PCB-PI
PCB-PJ
PCB-PK
PCB-PL
PCB-PM
pyruvate carboxykinase
NP_001163103.1
NP_610527.1
NP_724837.1
NP_724838.1
NP_724839.1
NP_724840.1
NP_724841.1
NP_724842.1
NP_724843.1
NP_724844.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9850703..9861543 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136683.3 → NP_610527.1  pyruvate carboxylase, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610527.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KN97
    Related
    FBpp0087540
    Conserved Domains (7) summary
    TIGR01235
    Location:41 → 1181
    pyruv_carbox; pyruvate carboxylase
    cd06850
    Location:1114 → 1180
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    cd07937
    Location:568 → 851
    DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain
    smart00878
    Location:377 → 484
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam00289
    Location:39 → 147
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02436
    Location:864 → 1062
    PYC_OADA; Conserved carboxylase domain
    pfam02786
    Location:153 → 360
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

  2. NM_165709.2 → NP_724841.1  pyruvate carboxylase, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724841.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E9E2
    Related
    FBpp0087539
    Conserved Domains (7) summary
    TIGR01235
    Location:41 → 1197
    pyruv_carbox; pyruvate carboxylase
    cd06850
    Location:1130 → 1196
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    cd07937
    Location:584 → 867
    DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain
    smart00878
    Location:377 → 484
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam00289
    Location:39 → 147
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02436
    Location:880 → 1078
    PYC_OADA; Conserved carboxylase domain
    cl17255
    Location:153 → 360
    ATP-grasp_4; ATP-grasp domain

  3. NM_165707.3 → NP_724839.1  pyruvate carboxylase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724839.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KN97
    Related
    FBpp0087541
    Conserved Domains (7) summary
    TIGR01235
    Location:41 → 1181
    pyruv_carbox; pyruvate carboxylase
    cd06850
    Location:1114 → 1180
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    cd07937
    Location:568 → 851
    DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain
    smart00878
    Location:377 → 484
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam00289
    Location:39 → 147
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02436
    Location:864 → 1062
    PYC_OADA; Conserved carboxylase domain
    pfam02786
    Location:153 → 360
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

  4. NM_001169632.2 → NP_001163103.1  pyruvate carboxylase, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163103.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E9E2
    Conserved Domains (7) summary
    TIGR01235
    Location:41 → 1197
    pyruv_carbox; pyruvate carboxylase
    cd06850
    Location:1130 → 1196
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    cd07937
    Location:584 → 867
    DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain
    smart00878
    Location:377 → 484
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam00289
    Location:39 → 147
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02436
    Location:880 → 1078
    PYC_OADA; Conserved carboxylase domain
    cl17255
    Location:153 → 360
    ATP-grasp_4; ATP-grasp domain

  5. NM_165705.3 → NP_724837.1  pyruvate carboxylase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724837.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KN97
    Related
    FBpp0087542
    Conserved Domains (7) summary
    TIGR01235
    Location:41 → 1181
    pyruv_carbox; pyruvate carboxylase
    cd06850
    Location:1114 → 1180
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    cd07937
    Location:568 → 851
    DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain
    smart00878
    Location:377 → 484
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam00289
    Location:39 → 147
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02436
    Location:864 → 1062
    PYC_OADA; Conserved carboxylase domain
    pfam02786
    Location:153 → 360
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

  6. NM_165710.3 → NP_724842.1  pyruvate carboxylase, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724842.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E9E2
    Related
    FBpp0087543
    Conserved Domains (7) summary
    TIGR01235
    Location:41 → 1197
    pyruv_carbox; pyruvate carboxylase
    cd06850
    Location:1130 → 1196
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    cd07937
    Location:584 → 867
    DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain
    smart00878
    Location:377 → 484
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam00289
    Location:39 → 147
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02436
    Location:880 → 1078
    PYC_OADA; Conserved carboxylase domain
    cl17255
    Location:153 → 360
    ATP-grasp_4; ATP-grasp domain

  7. NM_165706.2 → NP_724838.1  pyruvate carboxylase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724838.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KN97
    Related
    FBpp0087544
    Conserved Domains (7) summary
    TIGR01235
    Location:41 → 1181
    pyruv_carbox; pyruvate carboxylase
    cd06850
    Location:1114 → 1180
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    cd07937
    Location:568 → 851
    DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain
    smart00878
    Location:377 → 484
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam00289
    Location:39 → 147
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02436
    Location:864 → 1062
    PYC_OADA; Conserved carboxylase domain
    pfam02786
    Location:153 → 360
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

  8. NM_165711.2 → NP_724843.1  pyruvate carboxylase, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724843.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E9E2
    Related
    FBpp0087545
    Conserved Domains (7) summary
    TIGR01235
    Location:41 → 1197
    pyruv_carbox; pyruvate carboxylase
    cd06850
    Location:1130 → 1196
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    cd07937
    Location:584 → 867
    DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain
    smart00878
    Location:377 → 484
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam00289
    Location:39 → 147
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02436
    Location:880 → 1078
    PYC_OADA; Conserved carboxylase domain
    cl17255
    Location:153 → 360
    ATP-grasp_4; ATP-grasp domain

  9. NM_165708.2 → NP_724840.1  pyruvate carboxylase, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724840.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KN97
    Related
    FBpp0087547
    Conserved Domains (7) summary
    TIGR01235
    Location:41 → 1181
    pyruv_carbox; pyruvate carboxylase
    cd06850
    Location:1114 → 1180
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    cd07937
    Location:568 → 851
    DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain
    smart00878
    Location:377 → 484
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam00289
    Location:39 → 147
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02436
    Location:864 → 1062
    PYC_OADA; Conserved carboxylase domain
    pfam02786
    Location:153 → 360
    CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain

  10. NM_165712.2 → NP_724844.1  pyruvate carboxylase, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724844.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q0E9E2
    Related
    FBpp0087546
    Conserved Domains (7) summary
    TIGR01235
    Location:41 → 1197
    pyruv_carbox; pyruvate carboxylase
    cd06850
    Location:1130 → 1196
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    cd07937
    Location:584 → 867
    DRE_TIM_PC_TC_5S; Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain
    smart00878
    Location:377 → 484
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    pfam00289
    Location:39 → 147
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02436
    Location:880 → 1078
    PYC_OADA; Conserved carboxylase domain
    cl17255
    Location:153 → 360
    ATP-grasp_4; ATP-grasp domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0E9E2 Q0E9E2
Q7KN97 Q7KN97
Q86NV1 Q86NV1

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