fgf24 fibroblast growth factor 24 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fgf24provided by ZNC
Official Full Name: fibroblast growth factor 24provided by ZNC
Primary source: ZFIN:ZDB-GENE-030708-1
See related: Ensembl:ENSDARG00000037677 AllianceGenome:ZFIN:ZDB-GENE-030708-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: lbx1h; SI:zC207O21.2; si:zc207o21.1
Summary: Predicted to enable growth factor activity; type 1 fibroblast growth factor receptor binding activity; and type 2 fibroblast growth factor receptor binding activity. Acts upstream of or within several processes, including animal organ development; limb development; and negative regulation of endodermal cell fate specification. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including digestive system; fin bud; mesenchyme; mesoderm; and sensory system. Orthologous to human FGF18 (fibroblast growth factor 18). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (5506984..5546822, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (5200094..5239997, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

based on gene expression analysis, we find that differentiation of the inner mesenchymal somatic gonad cells into functional cell types in the larval and early juvenile-stage gonad is dependent on Fgf24 signaling.
Title: Fibroblast growth factor signaling is required for early somatic gonad development in zebrafish.
a mesodermal Fgf24 convergence cue controlled by Tbx5a underlies this asymmetric convergent motility.
Title: Asymmetric cell convergence-driven zebrafish fin bud initiation and pre-pattern requires Tbx5a control of a mesenchymal Fgf signal.
Data indicate that fgf20a, fgf24 and FGF receptor fgfr1 are expressed in normal and regenerating barbel tissue.
Title: Divergent requirements for fibroblast growth factor signaling in zebrafish maxillary barbel and caudal fin regeneration.
through the analysis of fgf10(-/-); fgf24(-/-) embryos, the specific role of these two FGF ligands in the induction of the ventral pancreas and in the repression of the hepatic fate was revealed.
Title: Essential roles of zebrafish bmp2a, fgf10, and fgf24 in the specification of the ventral pancreas.
Knockdown of fgf24 or sox3 causes severe epibranchial deficiencies but has little effect on otic development
Title: Pax2/8 proteins coordinate sequential induction of otic and epibranchial placodes through differential regulation of foxi1, sox3 and fgf24.
morphogenetic tissue rearrangements during eye evagination result in progenitor cells in the nasal half of the retina primordium being brought into proximity to the sources of three fibroblast growth factors, Fgf8/3/24, outside the eye.
Title: Dynamic coupling of pattern formation and morphogenesis in the developing vertebrate retina.
Fgf10 acts redundantly with Fgf24 in the pancreatic lateral plate mesoderm and they are both required to specify the ventral pancreas.
Title: Reciprocal endoderm-mesoderm interactions mediated by fgf24 and fgf10 govern pancreas development.
Results report the identification of a fibroblast growth factor (fgf) 8-related gene in zebrafish, fgf24, that is co-expressed with fgf8 in mesodermal precursors during gastrulation.
Title: Zebrafish fgf24 functions with fgf8 to promote posterior mesodermal development.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables type 1 fibroblast growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 2 fibroblast growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in dorsal/ventral pattern formation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ectodermal placode development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic heart tube development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic pectoral fin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic retina morphogenesis in camera-type eye	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within exocrine pancreas development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within gonad morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within limb bud formation	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within negative regulation of endodermal cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pectoral fin development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pectoral fin development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within peripheral nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fibroblast growth factor 24

Names: ika; ikarus; wfgf; wound fgf

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_182871.3 → NP_878291.2 fibroblast growth factor 24 precursor

See identical proteins and their annotated locations for NP_878291.2

Status: PROVISIONAL

Source sequence(s)

BC121748

UniProtKB/TrEMBL

Q0IIQ7

Related

ENSDARP00000054876.5, ENSDART00000054877.7

Conserved Domains (1) summary

pfam00167
Location:50 → 172

FGF; Fibroblast growth factor

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007125.7 Reference GRCz11 Primary Assembly

Range

5506984..5546822 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009307694.3 → XP_009305969.1 fibroblast growth factor 24 isoform X1

UniProtKB/TrEMBL

A0A8M3AZL7

Conserved Domains (1) summary

pfam00167
Location:50 → 169

FGF; Fibroblast growth factor