fgf10a fibroblast growth factor 10a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fgf10aprovided by ZNC
Official Full Name: fibroblast growth factor 10aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030715-1
See related: Ensembl:ENSDARG00000030932 AllianceGenome:ZFIN:ZDB-GENE-030715-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fgf10; fgf-10; wu:fd11d03; zgc:109774
Summary: Predicted to enable chemoattractant activity; growth factor activity; and type 2 fibroblast growth factor receptor binding activity. Acts upstream of or within several processes, including embryonic pectoral fin morphogenesis; posterior lateral line development; and regulation of hematopoietic stem cell differentiation. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including ectoderm; fin bud; gut; head; and lateral line system. Human ortholog(s) of this gene implicated in LADD syndrome and aplasia of lacrimal and salivary glands. Orthologous to human FGF10 (fibroblast growth factor 10). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 21

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	21	NC_007132.7 (19648817..19682616)
105	previous assembly	GRCz10 (GCF_000002035.5)	21	NC_007132.6 (19612181..19645980)

Chromosome 21 - NC_007132.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fgf3 and Fgf10a work in concert to promote maturation of the epibranchial placodes in zebrafish.
Title: Fgf3 and Fgf10a work in concert to promote maturation of the epibranchial placodes in zebrafish.
Fgf10 and Fgf3 secreted from the forming neurohypophysis exert direct guidance effects on hypothalamic neurosecretory axons.
Title: Direct and indirect roles of Fgf3 and Fgf10 in innervation and vascularisation of the vertebrate hypothalamic neurohypophysis.
through the analysis of fgf10(-/-); fgf24(-/-) embryos, the specific role of these two FGF ligands in the induction of the ventral pancreas and in the repression of the hepatic fate was revealed.
Title: Essential roles of zebrafish bmp2a, fgf10, and fgf24 in the specification of the ventral pancreas.
fgf10a, which is expressed in the mesenchyme surrounding non-hepatic endodermal cells, negatively impacts the regulative capacity of endodermal tissues.
Title: Intrinsic and extrinsic modifiers of the regulative capacity of the developing liver.
Functional investigation of a subset of these genes, fgf10a, tgfb2, pax9, and smad5 revealed their necessity in zebrafish palatogenesis.
Title: Examination of a palatogenic gene program in zebrafish.
Data show that the Ihha-Fgf10 regulatory interaction is realized through a signaling feedback loop between the Ihha-expressing epithelium and Fgf10-expressing mesenchyme.
Title: The interaction of epithelial Ihha and mesenchymal Fgf10 in zebrafish esophageal and swimbladder development.
These data provide in vivo evidence that endodermal cells outside the liver-forming region retain hepatic competence and show that an extrinsic signal, Fgf10a, negatively regulates hepatic competence.
Title: Restriction of hepatic competence by Fgf signaling.
rosettes form cyclically from a progenitor pool at the leading zone of the posterior lateral line primordium as neuromasts are deposited from trailing region; fgf3/10 signals localized to leading zone required for rosette formation & primordium migration
Title: FGF-dependent mechanosensory organ patterning in zebrafish.
Fgf10 acts redundantly with Fgf24 in the pancreatic lateral plate mesoderm and they are both required to specify the ventral pancreas.
Title: Reciprocal endoderm-mesoderm interactions mediated by fgf24 and fgf10 govern pancreas development.
Positional cloning identifies fgf10 as the gene disrupted in daedalus.
Title: HSPG synthesis by zebrafish Ext2 and Extl3 is required for Fgf10 signalling during limb development.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables chemoattractant activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables type 2 fibroblast growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within embryonic pectoral fin morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within liver development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within posterior lateral line neuromast development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within posterior lateral line neuromast primordium migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of hematopoietic stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within roof of mouth development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within swim bladder development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in wound healing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fibroblast growth factor 10a

Names: dae; daedalus; fibroblast growth factor 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.