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Su(var)2-10 Suppressor of variegation 2-10 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35927, updated on 22-Apr-2024

Summary

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Official Symbol
Su(var)2-10provided by FlyBase
Official Full Name
Suppressor of variegation 2-10provided by FlyBase
Primary source
FLYBASE:FBgn0003612
Locus tag
Dmel_CG8068
See related
AllianceGenome:FB:FBgn0003612
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8068; CLOT2057; Dmel\CG8068; DmPias; dpias; dPIAS; Dpias; DPIAS; i184; l(2)03697; pias; PIAS; Su(var)-10; Su(Var)2-10; SU(VAR)2-10; Su-var(2)10; Suvar(2)10; Sv210; zimp; ZIMP; ZimpA; ZimpB
Summary
Enables STAT family protein binding activity. Involved in several processes, including positive regulation of somatic stem cell division; protein sumoylation; and regulation of signal transduction. Located in chromosome, telomeric region; cytoplasm; and nuclear lumen. Is expressed in egg chamber; embryonic brain; larval ventral nerve cord; and organism. Used to study hematologic cancer. Orthologous to several human genes including PIAS1 (protein inhibitor of activated STAT 1); PIAS2 (protein inhibitor of activated STAT 2); and PIAS3 (protein inhibitor of activated STAT 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
45A8-45A9; 2-60 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (9116122..9122000)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (5003627..5009505)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Mystery 45A Neighboring gene tsunagi Neighboring gene Phosphorylated adaptor for RNA export Neighboring gene Glutathione S transferase E13 Neighboring gene uncharacterized protein Neighboring gene alpha/beta hydrolase 1 Neighboring gene alicorn

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SUMO-2 and PIAS1 modulate insoluble mutant huntingtin protein accumulation. O'Rourke JG, et al. Cell Rep, 2013 Jul 25. PMID 23871671, Free PMC Article
  2. Epigenetic stability increases extensively during Drosophila follicle stem cell differentiation. Skora AD, et al. Proc Natl Acad Sci U S A, 2010 Apr 20. PMID 20368445, Free PMC Article
  3. A new RING for SUMO: wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligases. Jackson PK. Genes Dev, 2001 Dec 1. PMID 11731472
  4. Zimp encodes a homologue of mouse Miz1 and PIAS3 and is an essential gene in Drosophila melanogaster. Mohr SE, et al. Gene, 1999 Mar 18. PMID 10095110
  5. A high proportion of genes involved in position effect variegation also affect chromosome inheritance. Le HD, et al. Chromosoma, 2004 Mar. PMID 14767778, Free PMC Article

See all (146) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Direct interaction of Su(var)2-10 via the SIM-binding site of the Piwi protein is required for transposon silencing in Drosophila melanogaster.
    Title: Direct interaction of Su(var)2-10 via the SIM-binding site of the Piwi protein is required for transposon silencing in Drosophila melanogaster.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables SUMO ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SUMO ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromosome condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromosome organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromosome organization TAS
Traceable Author Statement
more info
 PubMed 
involved_in compound eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye development TAS
Traceable Author Statement
more info
 PubMed 
involved_in defense response to Gram-negative bacterium HMP PubMed 
involved_in double-strand break repair via homologous recombination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc growth TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of peptidoglycan recognition protein signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of receptor signaling pathway via JAK-STAT IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of receptor signaling pathway via JAK-STAT IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of innate immune response HMP PubMed 
involved_in positive regulation of smoothened signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of somatic stem cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein sumoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein sumoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein sumoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein sumoylation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome, telomeric region IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear lamina IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
suppressor of variegation 2-10
Names
CG8068-PA
CG8068-PB
CG8068-PC
CG8068-PD
CG8068-PE
CG8068-PF
CG8068-PG
CG8068-PH
CG8068-PI
CG8068-PJ
CG8068-PK
CG8068-PL
CG8068-PM
CG8068-PN
Su(var)2-10-PA
Su(var)2-10-PB
Su(var)2-10-PC
Su(var)2-10-PD
Su(var)2-10-PE
Su(var)2-10-PF
Su(var)2-10-PG
Su(var)2-10-PH
Su(var)2-10-PI
Su(var)2-10-PJ
Su(var)2-10-PK
Su(var)2-10-PL
Su(var)2-10-PM
Su(var)2-10-PN
protein inhibitor of activated STAT
zinc finger-containing Miz1 PIAS3-like
NP_001286228.1
  • unusual splice

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    9116122..9122000
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001201959.2 → NP_001188888.1  suppressor of variegation 2-10, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188888.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JD33, C1C3E9
    Conserved Domains (3) summary
    smart00513
    Location:49 → 83
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:368 → 417
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:171 → 307
    PINIT; PINIT domain

  2. NM_001299299.1 → NP_001286228.1  suppressor of variegation 2-10, isoform N [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286228.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4LEH9, C1C3E9
    Conserved Domains (3) summary
    smart00513
    Location:49 → 83
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:368 → 417
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:171 → 307
    PINIT; PINIT domain

  3. NM_001259286.2 → NP_001246215.1  suppressor of variegation 2-10, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246215.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4K6T9, C1C3E9
    Conserved Domains (3) summary
    smart00513
    Location:49 → 83
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:368 → 417
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:171 → 307
    PINIT; PINIT domain

  4. NM_165645.2 → NP_724749.1  suppressor of variegation 2-10, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724749.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7P5, C1C3E9
    Related
    FBpp0087651
    Conserved Domains (3) summary
    smart00513
    Location:49 → 83
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:368 → 417
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:171 → 307
    PINIT; PINIT domain

  5. NM_165647.3 → NP_724751.1  suppressor of variegation 2-10, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724751.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7P7, C1C3E9
    Related
    FBpp0087652
    Conserved Domains (3) summary
    smart00513
    Location:49 → 83
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:368 → 417
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:171 → 307
    PINIT; PINIT domain

  6. NM_165646.2 → NP_724750.1  suppressor of variegation 2-10, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724750.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C1C3E9, Q8IGK3
    Related
    FBpp0087653
    Conserved Domains (3) summary
    smart00513
    Location:49 → 83
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:368 → 417
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:171 → 307
    PINIT; PINIT domain

  7. NM_001201957.2 → NP_001188886.1  suppressor of variegation 2-10, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188886.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JD03, C1C3E9
    Conserved Domains (3) summary
    smart00513
    Location:2 → 36
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:321 → 370
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:124 → 260
    PINIT; PINIT domain

  8. NM_001201958.2 → NP_001188887.1  suppressor of variegation 2-10, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188887.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JCQ7, C1C3E9
    Conserved Domains (3) summary
    smart00513
    Location:13 → 47
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:332 → 381
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:135 → 271
    PINIT; PINIT domain

  9. NM_165648.3 → NP_724752.1  suppressor of variegation 2-10, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724752.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7P8, C1C3E9
    Related
    FBpp0087656
    Conserved Domains (3) summary
    smart00513
    Location:13 → 47
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:332 → 381
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:135 → 271
    PINIT; PINIT domain

  10. NM_165651.2 → NP_724755.1  suppressor of variegation 2-10, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724755.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7Q1, C1C3E9
    Related
    FBpp0087658
    Conserved Domains (3) summary
    smart00513
    Location:2 → 36
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:321 → 370
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:124 → 260
    PINIT; PINIT domain

  11. NM_165649.2 → NP_724753.1  suppressor of variegation 2-10, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724753.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z7P9, C1C3E9
    Related
    FBpp0087654
    Conserved Domains (3) summary
    smart00513
    Location:13 → 47
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:332 → 381
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:135 → 271
    PINIT; PINIT domain

  12. NM_165652.3 → NP_724756.1  suppressor of variegation 2-10, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724756.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C1C3E9, Q9XYM5
    Related
    FBpp0087657
    Conserved Domains (3) summary
    smart00513
    Location:2 → 36
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:321 → 370
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:124 → 260
    PINIT; PINIT domain

  13. NM_078940.3 → NP_523664.1  suppressor of variegation 2-10, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523664.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C1C3E9, Q7KNF5
    Related
    FBpp0087659
    Conserved Domains (3) summary
    smart00513
    Location:2 → 36
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:321 → 370
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:124 → 260
    PINIT; PINIT domain

  14. NM_165650.3 → NP_724754.1  suppressor of variegation 2-10, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724754.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C1C3E9, Q5BIG7
    Related
    FBpp0087655
    Conserved Domains (3) summary
    smart00513
    Location:13 → 47
    SAP; Putative DNA-binding (bihelical) motif predicted to be involved in chromosomal organisation
    pfam02891
    Location:332 → 381
    zf-MIZ; MIZ/SP-RING zinc finger
    pfam14324
    Location:135 → 271
    PINIT; PINIT domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4JCQ7 A0A0B4JCQ7
A0A0B4JD03 A0A0B4JD03
A0A0B4JD33 A0A0B4JD33
A0A0B4K6T9 A0A0B4K6T9
A0A0B4LEH9 A0A0B4LEH9
A1Z7P5 A1Z7P5
A1Z7P7 A1Z7P7
A1Z7P8 A1Z7P8
A1Z7P9 A1Z7P9
A1Z7Q1 A1Z7Q1
Q5BIG7 Q5BIG7
Q7KNF5 Q7KNF5
Q8IGK3 Q8IGK3
Q9XYM5 Q9XYM5

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