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Pabp2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35788, updated on 10-May-2024

Summary

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Official Symbol
Pabp2provided by FlyBase
Primary source
FLYBASE:FBgn0005648
Locus tag
Dmel_CG2163
See related
AllianceGenome:FB:FBgn0005648
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG2163; Dmel\CG2163; dpabII; pabp2; pAbp2; PABP2; PABPN1; rox2; Rox2; ROX2
Summary
Enables poly(A) binding activity. Involved in mRNA polyadenylation; nuclear-transcribed mRNA poly(A) tail shortening; and positive regulation of protein glycosylation. Located in cytoplasm and nucleus. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in several structures, including adult head and female-specific anatomical entity. Human ortholog(s) of this gene implicated in oculopharyngeal muscular dystrophy. Orthologous to several human genes including PABPN1 (poly(A) binding protein nuclear 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
44B3-44B3; 2-58 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8131431..8134374)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4018936..4021879)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Nucleoporin 50kD Neighboring gene coilin Neighboring gene Suppressor of Cytokine Signaling at 44A Neighboring gene uncharacterized protein Neighboring gene PSEA-binding protein 49kD Neighboring gene Odorant-binding protein 44a Neighboring gene Lipin Neighboring gene kermit Neighboring gene long non-coding RNA:CR44068 Neighboring gene pseudo

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Drosophila poly(A)-binding protein II is ubiquitous throughout Drosophila development and has the same function in mRNA polyadenylation as its bovine homolog in vitro. Benoit B, et al. Nucleic Acids Res, 1999 Oct 1. PMID 10481015, Free PMC Article
  2. Mutational analysis of the eyeless gene and phenotypic rescue reveal that an intact Eyeless protein is necessary for normal eye and brain development in Drosophila. Clements J, et al. Dev Biol, 2009 Oct 15. PMID 19666017, Free PMC Article
  3. Novel Drosophila melanogaster genes encoding RRM-type RNA-binding proteins identified by a degenerate PCR strategy. Brand SF, et al. Gene, 1995 Mar 10. PMID 7890163
  4. Global changes of the RNA-bound proteome during the maternal-to-zygotic transition in Drosophila. Sysoev VO, et al. Nat Commun, 2016 Jul 5. PMID 27378189, Free PMC Article
  5. PABPN1 suppresses TDP-43 toxicity in ALS disease models. Chou CC, et al. Hum Mol Genet, 2015 Sep 15. PMID 26130692, Free PMC Article

See all (92) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. the first step of the cleavage and polyadenylation reaction, mRNA cleavage, is affected in muscles expressing alanine-expanded PABPN1. We propose that impaired cleavage is an early defect in Oculopharyngeal muscular dystrophy.
    Title: Mitochondrial dysfunction reveals the role of mRNA poly(A) tail regulation in oculopharyngeal muscular dystrophy pathogenesis.
  2. Results suggest that oculopharyngeal muscular dystrophy does not result from polyalanine toxicity, but from an intrinsic
    Title: A Drosophila model of oculopharyngeal muscular dystrophy reveals intrinsic toxicity of PABPN1.
  3. Results identify the poly(A) binding protein PABP2 as a regulator of maternal mRNA poly(A) tail length and highlight the importance of this mode of translational control.
    Title: An essential cytoplasmic function for the nuclear poly(A) binding protein, PABP2, in poly(A) tail length control and early development in Drosophila.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(A) binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(A) binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables poly(A) binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in mRNA 3'-end processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in nuclear-transcribed mRNA poly(A) tail shortening IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of precatalytic spliceosome HDA PubMed 

General protein information

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Preferred Names
Pabp2
Names
CG2163-PA
CG2163-PB
Pabp2-PA
Pabp2-PB
nuclear poly(A)-binding protein
poly-A binding protein 2
polyA-binding protein II

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8131431..8134374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057554.4 → NP_476902.1  Pabp2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476902.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1Z7B1, Q27926, Q7JQ60, Q7KNF2
    UniProtKB/TrEMBL
    E2QC83
    Related
    FBpp0087863
    Conserved Domains (2) summary
    COG0724
    Location:43 → 172
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12550
    Location:97 → 172
    RRM_II_PABPN1; RNA recognition motif in type II polyadenylate-binding protein 2 (PABP-2) and similar proteins

  2. NM_165589.3 → NP_724648.1  Pabp2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724648.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A1Z7B1, Q27926, Q7JQ60, Q7KNF2
    UniProtKB/TrEMBL
    E2QC83
    Related
    FBpp0087864
    Conserved Domains (2) summary
    COG0724
    Location:43 → 172
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12550
    Location:97 → 172
    RRM_II_PABPN1; RNA recognition motif in type II polyadenylate-binding protein 2 (PABP-2) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E2QC83 E2QC83
Q7KNF2.1 Q7KNF2

Gene LinkOut

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