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IL9 interleukin 9 [ Homo sapiens (human) ]

Gene ID: 3578, updated on 4-Jan-2025

Summary

Official Symbol
IL9provided by HGNC
Official Full Name
interleukin 9provided by HGNC
Primary source
HGNC:HGNC:6029
See related
Ensembl:ENSG00000145839 MIM:146931; AllianceGenome:HGNC:6029
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P40; HP40; IL-9
Summary
The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See IL9 in Genome Data Viewer
Location:
5q31.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (135892246..135895841, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (136414743..136418342, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (135227935..135231530, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene solute carrier family 25 member 48 Neighboring gene microRNA 5692c-1 Neighboring gene uncharacterized LOC107986453 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:135169317-135169818 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:135213247-135213748 Neighboring gene uncharacterized LOC124901074 Neighboring gene F-box and leucine rich repeat protein 21, pseudogene Neighboring gene leukocyte cell derived chemotaxin 2

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

Related articles in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity  
enables cytokine activity PubMed 
enables growth factor activity  
enables interleukin-9 receptor binding  
Component Evidence Code Pubs
located_in extracellular region  
is_active_in extracellular space  
is_active_in extracellular space PubMed 

General protein information

Preferred Names
interleukin-9
Names
T-cell growth factor p40
cytokine P40
homolog of mouse T cell and mast cell growth factor 40
p40 T-cell and mast cell growth factor
p40 cytokine

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000590.2NP_000581.1  interleukin-9 precursor

    See identical proteins and their annotated locations for NP_000581.1

    Status: REVIEWED

    Source sequence(s)
    AC002428, S63356
    Consensus CDS
    CCDS4189.1
    UniProtKB/Swiss-Prot
    P15248
    UniProtKB/TrEMBL
    Q6NZ74, Q6NZ75
    Related
    ENSP00000274520.1, ENST00000274520.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    135892246..135895841 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    136414743..136418342 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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