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U2A [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35713, updated on 10-May-2024

Summary

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Official Symbol
U2Aprovided by FlyBase
Primary source
FLYBASE:FBgn0033210
Locus tag
Dmel_CG1406
See related
AllianceGenome:FB:FBgn0033210
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE56869; CG1406; Dmel\CG1406; dU2A; dU2A'; l(2)43Ee; u2a; U2A'; U2A-prime
Summary
Predicted to enable U2 snRNA binding activity. Involved in chromatin organization and spermatogenesis. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in organism; ovary; and testis. Used to study azoospermia. Human ortholog(s) of this gene implicated in connective tissue disease. Orthologous to human SNRPA1 (small nuclear ribonucleoprotein polypeptide A'). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
43E9-43E9; 2-57 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7675362..7676362, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3562867..3563867, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L52 Neighboring gene uncharacterized protein Neighboring gene Leucine-rich repeat Neighboring gene uncharacterized protein Neighboring gene Coenzyme Q9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Linkage and allostery in snRNP protein/RNA complexes. Williams SG, et al. Biochemistry, 2014 Jun 10. PMID 24849693, Free PMC Article
  2. Functioning of the Drosophila Wilms'-tumor-1-associated protein homolog, Fl(2)d, in Sex-lethal-dependent alternative splicing. Penn JK, et al. Genetics, 2008 Feb. PMID 18245840, Free PMC Article
  3. Prp22 and spliceosome components regulate chromatin dynamics in germ-line polyploid cells. Klusza S, et al. PLoS One, 2013. PMID 24244416, Free PMC Article
  4. Molecular principles underlying dual RNA specificity in the Drosophila SNF protein. Weber G, et al. Nat Commun, 2018 Jun 7. PMID 29880797, Free PMC Article
  5. Major spliceosome defects cause male infertility and are associated with nonobstructive azoospermia in humans. Wu H, et al. Proc Natl Acad Sci U S A, 2016 Apr 12. PMID 27035939, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables U2 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chromatin organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in mitotic cell cycle HMP PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of U2 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome HDA PubMed 
part_of precatalytic spliceosome HDA PubMed 
part_of small nuclear ribonucleoprotein complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
U2A
Names
CG1406-PA
U2A-PA
lethal(2)43Ee

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7675362..7676362 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136471.4 → NP_610315.1  U2A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610315.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V4Q8
    Related
    FBpp0088015
    Conserved Domains (4) summary
    pfam14580
    Location:1 → 175
    LRR_9; Leucine-rich repeat
    sd00031
    Location:46 → 65
    LRR_1; leucine-rich repeat [structural motif]
    sd00033
    Location:22 → 43
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:46 → 81
    LRR_4; Leucine Rich repeats (2 copies)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V4Q8.1 Q9V4Q8

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