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Rpt1 Regulatory particle triple-A ATPase 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35701, updated on 5-May-2024

Summary

Official Symbol
Rpt1provided by FlyBase
Official Full Name
Regulatory particle triple-A ATPase 1provided by FlyBase
Primary source
FLYBASE:FBgn0028687
Locus tag
Dmel_CG1341
See related
AllianceGenome:FB:FBgn0028687
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
1341; anon-WO0118547.90; CG1341; Dmel\CG1341; Dmp48B; Dm_Rpt1; dRpt1; l(2)05643; l(2)43Ed; p48B; Q7KMQ0_DROME; S7
Summary
Predicted to enable proteasome-activating activity. Involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in polytene chromosome. Part of proteasome regulatory particle, base subcomplex. Is expressed in adult head and organism. Orthologous to human PSMC2 (proteasome 26S subunit, ATPase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:
43E7-43E7; 2-57 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7652440..7653954, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3539945..3541459, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44444 Neighboring gene Myosin-7a binding protein Neighboring gene antisense RNA:CR45131 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables proteasome-activating activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables proteasome-activating activity ISM
Inferred from Sequence Model
more info
PubMed 
Component Evidence Code Pubs
located_in polytene chromosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome regulatory particle IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome regulatory particle ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
part_of proteasome regulatory particle, base subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of proteasome regulatory particle, base subcomplex IDA
Inferred from Direct Assay
more info
PubMed 
part_of proteasome regulatory particle, base subcomplex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
regulatory particle triple-A ATPase 1
Names
19S complex subunit Rpt1
AAA ATPase
CG1341-PA
Rpt1-PA
lethal(2)43Ed
NP_477473.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7652440..7653954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058125.5NP_477473.1  regulatory particle triple-A ATPase 1 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477473.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KMQ0
    Related
    FBpp0088021
    Conserved Domains (1) summary
    COG1222
    Location:27430
    RPT1; ATP-dependent 26S proteasome regulatory subunit [Posttranslational modification, protein turnover, chaperones]