U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

pdha-1 Pyruvate dehydrogenase E1 component subunit alpha;putative pyruvate dehydrogenase E1 component subunit alpha, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 3565996, updated on 23-Nov-2023

Summary

Go to the top of the page Help
Gene symbol
pdha-1
Gene description
Pyruvate dehydrogenase E1 component subunit alpha;putative pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
Primary source
WormBase:WBGene00011510
Locus tag
CELE_T05H10.6
See related
AllianceGenome:WB:WBGene00011510
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable pyruvate dehydrogenase (acetyl-transferring) activity. Predicted to be involved in acetyl-CoA biosynthetic process from pyruvate. Located in mitochondrion. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1) and PDHA2 (pyruvate dehydrogenase E1 subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: II
Exon count:
4
Sequence:
Chromosome: II; NC_003280.10 (8066287..8068184)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Ubiquitin conjugation factor E4 ufd-2 Neighboring gene Putative glycerophosphocholine phosphodiesterase GPCPD1 homolog 2 Neighboring gene ncRNA Neighboring gene DUF19 domain-containing protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. In vivo metabolic flux profiling with stable isotopes discriminates sites and quantifies effects of mitochondrial dysfunction in C. elegans. Vergano SS, et al. Mol Genet Metab, 2014 Mar. PMID 24445252, Free PMC Article
  2. Global Proteomic Response of Caenorhabditis elegans Against PemK(Sa) Toxin. Mir DA, et al. Front Cell Infect Microbiol, 2019. PMID 31214513, Free PMC Article
  3. Dietary restriction by growth in axenic medium induces discrete changes in the transcriptional output of genes involved in energy metabolism in Caenorhabditis elegans. Castelein N, et al. Biotechnol J, 2008 Jun. PMID 18383023
  4. Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans. McElwee JJ, et al. Mech Ageing Dev, 2006 May. PMID 16522328
  5. The matrix peptide exporter HAF-1 signals a mitochondrial UPR by activating the transcription factor ZC376.7 in C. elegans. Haynes CM, et al. Mol Cell, 2010 Feb 26. PMID 20188671, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables pyruvate dehydrogenase (acetyl-transferring) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyruvate dehydrogenase (acetyl-transferring) activity IEA
Inferred from Electronic Annotation
more info
  
enables pyruvate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acetyl-CoA biosynthetic process from pyruvate IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in acetyl-CoA biosynthetic process from pyruvate IEA
Inferred from Electronic Annotation
more info
  
involved_in glycolytic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pyruvate metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Pyruvate dehydrogenase E1 component subunit alpha;putative pyruvate dehydrogenase E1 component subunit alpha, mitochondrial
NP_001379071.1
  • Confirmed by transcript evidence
NP_871953.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    8066287..8068184
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_182153.6 → NP_871953.1  Pyruvate dehydrogenase E1 component subunit alpha [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_871953.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8I111
    Conserved Domains (1) summary
    cl01629
    Location:51 → 391
    TPP_enzymes; Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and ...

  2. NM_001393133.1 → NP_001379071.1  putative pyruvate dehydrogenase E1 component subunit alpha, mitochondrial [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P52899
    Conserved Domains (1) summary
    cl01629
    Location:34 → 374
    TPP_enzymes; Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52899.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous