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Dhx15 DEAH-box helicase 15 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35654, updated on 10-May-2024

Summary

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Official Symbol
Dhx15provided by FlyBase
Official Full Name
DEAH-box helicase 15provided by FlyBase
Primary source
FLYBASE:FBgn0033160
Locus tag
Dmel_CG11107
See related
AllianceGenome:FB:FBgn0033160
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Liang-1.18; cg11107; CG11107; clone 1.18; DHX15; Dmel\CG11107
Summary
Predicted to enable RNA binding activity and RNA helicase activity. Involved in positive regulation of p38MAPK cascade. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in adult head; embryonic/larval midgut; gonad; and organism. Orthologous to human DHX15 (DEAH-box helicase 15). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
43B2-43B2; 2-56 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7387187..7391023)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3274692..3278528)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Down syndrome cell adhesion molecule 1 Neighboring gene antisense RNA:CR44071 Neighboring gene costa Neighboring gene antisense RNA:CR44201 Neighboring gene Gustatory receptor 43a Neighboring gene Glyoxalase 1 Neighboring gene uncharacterized protein Neighboring gene ELL-associated factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The DEAH-box RNA helicase DHX15 activates NF-κB and MAPK signaling downstream of MAVS during antiviral responses. Mosallanejad K, et al. Sci Signal, 2014 Apr 29. PMID 24782566
  2. Tracing the origin of the compensasome: evolutionary history of DEAH helicase and MYST acetyltransferase gene families. Sanjuán R, et al. Mol Biol Evol, 2001 Mar. PMID 11230534
  3. Genes involved in Drosophila glutamate receptor expression and localization. Liebl FL, et al. BMC Neurosci, 2005 Jun 28. PMID 15985179, Free PMC Article
  4. SSCP analysis of cDNA markers provides a dense linkage map of the Aedes aegypti genome. Fulton RE, et al. Genetics, 2001 Jun. PMID 11404335, Free PMC Article
  5. Eve and ftz regulate a wide array of genes in blastoderm embryos: the selector homeoproteins directly or indirectly regulate most genes in Drosophila. Liang Z, et al. Development, 1998 Nov. PMID 9778506

See all (45) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA helicase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of p38MAPK cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome HDA PubMed 
is_active_in intracellular anatomical structure IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of precatalytic spliceosome HDA PubMed 
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spliceosomal complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
DEAH-box helicase 15
Names
CG11107-PA
CG11107-PB
DHX15 ortholog
Dhx15-PA
Dhx15-PB
NP_001260766.1
NP_610269.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7387187..7391023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136425.3 → NP_610269.1  DEAH-box helicase 15, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610269.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7K3M5
    Related
    FBpp0088040
    Conserved Domains (6) summary
    smart00490
    Location:315 → 408
    HELICc; helicase superfamily c-terminal domain
    smart00487
    Location:67 → 255
    DEXDc; DEAD-like helicases superfamily
    smart00847
    Location:478 → 561
    HA2; Helicase associated domain (HA2) Add an annotation
    cd00046
    Location:91 → 228
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cl22853
    Location:50 → 102
    Motor_domain; Myosin and Kinesin motor domain
    pfam07717
    Location:595 → 698
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold

  2. NM_001273837.1 → NP_001260766.1  DEAH-box helicase 15, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260766.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7K3M5
    Conserved Domains (6) summary
    smart00490
    Location:315 → 408
    HELICc; helicase superfamily c-terminal domain
    smart00487
    Location:67 → 255
    DEXDc; DEAD-like helicases superfamily
    smart00847
    Location:478 → 561
    HA2; Helicase associated domain (HA2) Add an annotation
    cd00046
    Location:91 → 228
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    cl22853
    Location:50 → 102
    Motor_domain; Myosin and Kinesin motor domain
    pfam07717
    Location:595 → 698
    OB_NTP_bind; Oligonucleotide/oligosaccharide-binding (OB)-fold
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K3M5.1 Q7K3M5

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