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madd-3 Protein kinase domain-containing protein;putative dual specificity protein kinase madd-3 [ Caenorhabditis elegans ]

Gene ID: 3565068, updated on 5-May-2024

Summary

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Gene symbol
madd-3
Gene description
Protein kinase domain-containing protein;putative dual specificity protein kinase madd-3
Primary source
WormBase:WBGene00006517
Locus tag
CELE_E02H4.3
See related
AllianceGenome:WB:WBGene00006517
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATP binding activity; protein serine/threonine kinase activity; and protein tyrosine kinase activity. Predicted to be involved in peptidyl-tyrosine phosphorylation. Predicted to be located in cytoplasm and nucleus. Is expressed in anal depressor muscle; anal sphincter muscle; body wall musculature; and vulval muscle. Orthologous to several human genes including CLK2 (CDC like kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
chromosome: X
Exon count:
13
Sequence:
Chromosome: X; NC_003284.9 (14284752..14296659, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Amiloride-sensitive sodium channel subunit alpha;Degenerin del-1 Neighboring gene ncRNA Neighboring gene MIF4G domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The MADD-3 LAMMER Kinase Interacts with a p38 MAP Kinase Pathway to Regulate the Display of the EVA-1 Guidance Receptor in Caenorhabditis elegans. D'Souza SA, et al. PLoS Genet, 2016 Apr. PMID 27123983, Free PMC Article
  2. The embryonic muscle transcriptome of Caenorhabditis elegans. Fox RM, et al. Genome Biol, 2007. PMID 17848203, Free PMC Article
  3. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein kinase domain-containing protein;putative dual specificity protein kinase madd-3
NP_001355370.1
  • Confirmed by transcript evidence
NP_001355453.1
  • Confirmed by transcript evidence
NP_001368709.1
  • Partially confirmed by transcript evidence
NP_001380238.1
  • Confirmed by transcript evidence
NP_001380239.1
  • Confirmed by transcript evidence
NP_741928.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    14284752..14296659 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171799.8 → NP_741928.1  putative dual specificity protein kinase madd-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741928.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EDB2, G5EGK0
    Conserved Domains (2) summary
    cd14134
    Location:538 → 863
    PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases
    cl26464
    Location:73 → 364
    Atrophin-1; Atrophin-1 family

  2. NM_001392883.1 → NP_001380239.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3B1E026
    Conserved Domains (1) summary
    cd14134
    Location:1 → 248
    PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases

  3. NM_001368550.4 → NP_001355370.1  putative dual specificity protein kinase madd-3 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cd14134
    Location:244 → 572
    PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases

  4. NM_001392884.1 → NP_001380238.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3B1E4Y4
    Conserved Domains (1) summary
    cd14134
    Location:1 → 251
    PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases

  5. NM_001368549.4 → NP_001355453.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3B1DR12
    Conserved Domains (1) summary
    cd14134
    Location:244 → 569
    PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases

  6. NM_001381143.1 → NP_001368709.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A3B1E657
    Conserved Domains (2) summary
    PHA03247
    Location:73 → 364
    PHA03247; large tegument protein UL36; Provisional
    cd14134
    Location:538 → 866
    PKc_CLK; Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EDB2.1

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