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rict-1 RICTOR_N domain-containing protein;Rapamycin-insensitive companion of mTOR domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 3565035, updated on 23-Nov-2023

Summary

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Gene symbol
rict-1
Gene description
RICTOR_N domain-containing protein;Rapamycin-insensitive companion of mTOR domain-containing protein
Primary source
WormBase:WBGene00009245
Locus tag
CELE_F29C12.3
See related
AllianceGenome:WB:WBGene00009245
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein serine/threonine kinase activator activity. Involved in mesendoderm development. Part of TORC2 complex. Is expressed in several structures, including head neurons; intestine; pharynx; spermatheca; and ventral nerve cord. Orthologous to human RICTOR (RPTOR independent companion of MTOR complex 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See rict-1 in Genome Data Viewer
Location:
chromosome: II
Exon count:
16
Sequence:
Chromosome: II; NC_003280.10 (13098239..13116810, complement)

Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene DUF3444 domain-containing protein Neighboring gene Eukaryotic translation initiation factor 2-alpha kinase gcn-2 Neighboring gene DUF19 domain-containing protein Neighboring gene Collagen triple helix repeat protein;Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene protein of unknown function DB domain-containing protein Neighboring gene Elongation factor G, mitochondrial Neighboring gene BTB and MATH domain-containing protein 45

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitochondrial Perturbations Couple mTORC2 to Autophagy in C. elegans. Aspernig H, et al. Cell Rep, 2019 Nov 5. PMID 31693882
  2. Rictor/TORC2 mediates gut-to-brain signaling in the regulation of phenotypic plasticity in C. elegans. O'Donnell MP, et al. PLoS Genet, 2018 Feb. PMID 29415022, Free PMC Article
  3. mTORC2-SGK-1 acts in two environmentally responsive pathways with opposing effects on longevity. Mizunuma M, et al. Aging Cell, 2014 Oct. PMID 25040785, Free PMC Article
  4. A comparative study of fat storage quantitation in nematode Caenorhabditis elegans using label and label-free methods. Yen K, et al. PLoS One, 2010 Sep 16. PMID 20862331, Free PMC Article
  5. The intestinal TORC2 signaling pathway contributes to associative learning in Caenorhabditis elegans. Sakai N, et al. PLoS One, 2017. PMID 28542414, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in TOR signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in TORC2 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mesendoderm development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TORC2 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of TORC2 complex IEA
Inferred from Electronic Annotation
more info
  
part_of TORC2 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
RICTOR_N domain-containing protein;Rapamycin-insensitive companion of mTOR domain-containing protein
NP_001254376.1
  • Confirmed by transcript evidence
NP_001254377.1
  • Confirmed by transcript evidence
NP_001254378.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003280.10 Reference assembly

    Range
    13098239..13116810 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001267447.2 → NP_001254376.1  RICTOR_N domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254376.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFK2
    Conserved Domains (4) summary
    pfam14663
    Location:890 → 991
    RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
    pfam14664
    Location:94 → 499
    RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
    pfam14666
    Location:783 → 883
    RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
    pfam14668
    Location:1055 → 1121
    RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

  2. NM_001267448.2 → NP_001254377.1  RICTOR_N domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254377.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EFN2
    Conserved Domains (4) summary
    pfam14663
    Location:892 → 993
    RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
    pfam14664
    Location:94 → 501
    RICTOR_N; Rapamycin-insensitive companion of mTOR, N-term
    pfam14666
    Location:785 → 885
    RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
    pfam14668
    Location:1057 → 1123
    RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5

  3. NM_001267449.3 → NP_001254378.1  Rapamycin-insensitive companion of mTOR domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001254378.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ED67
    Conserved Domains (3) summary
    pfam14663
    Location:80 → 181
    RasGEF_N_2; Rapamycin-insensitive companion of mTOR RasGEF_N domain
    pfam14666
    Location:2 → 73
    RICTOR_M; Rapamycin-insensitive companion of mTOR, middle domain
    pfam14668
    Location:245 → 311
    RICTOR_V; Rapamycin-insensitive companion of mTOR, domain 5
Nucleotide Protein
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