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IL1RN interleukin 1 receptor antagonist [ Homo sapiens (human) ]

Gene ID: 3557, updated on 20-Apr-2024

Summary

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Official Symbol
IL1RNprovided by HGNC
Official Full Name
interleukin 1 receptor antagonistprovided by HGNC
Primary source
HGNC:HGNC:6000
See related
Ensembl:ENSG00000136689 MIM:147679; AllianceGenome:HGNC:6000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DIRA; IRAP; CRMO2; IL1F3; IL1RA; MVCD4; IL-1RN; IL-1ra; IL-1ra3; ICIL-1RA
Summary
The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses, particularly in the acute phase of infection and inflammation. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2020]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Biased expression in esophagus (RPKM 367.9), bone marrow (RPKM 53.9) and 2 other tissues See more
Orthologs
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Genomic context

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Location:
2q14.1
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (113099360..113134014)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (113544556..113560594)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (113875548..113891591)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:113835447-113836646 Neighboring gene interleukin 1 family member 10 Neighboring gene Sharpr-MPRA regulatory region 10370 Neighboring gene RNA, U6 small nuclear 1180, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16410 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16411 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16412 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11878 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11879 Neighboring gene Sharpr-MPRA regulatory region 7144 Neighboring gene uncharacterized LOC124907872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:113930391-113930891 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:113929890-113930390 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16413 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16414 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16415 Neighboring gene pleckstrin and Sec7 domain containing 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11880 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16416 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16417 Neighboring gene Sharpr-MPRA regulatory region 2961 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16418 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11881 Neighboring gene paired box 8 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:113998497-113999696 Neighboring gene PAX8 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The influence of IL1RN VNTR polymorphism on HPV infection among some tribal communities. Goswami A, et al. J Med Virol, 2022 Feb. PMID 34741549
  2. Genetic polymorphism of interleukin-1 receptor antagonist in Type 1 diabetic children. Abed NT, et al. Pediatr Res, 2022 May. PMID 34002010
  3. Interleukin-1 gene polymorphisms in axial spondyloarthritis Tunisian patients. Tekaya R, et al. Tunis Med, 2020 Dec. PMID 33480001
  4. Analysis of the expression and potential molecular mechanism of interleukin-1 receptor antagonist (IL1RN) in papillary thyroid cancer via bioinformatics methods. Xie Z, et al. BMC Cancer, 2020 Nov 25. PMID 33238942, Free PMC Article
  5. Serum IL-1RA levels increase from follicular to luteal phase of the ovarian cycle: A pilot study on human female immune responses. Vetrano M, et al. PLoS One, 2020. PMID 32881904, Free PMC Article

See all (1037) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Influence of Genetic Polymorphisms on the Expression of Interleukin-1beta, Prostaglandin E2 and Tumor Necrosis Factor Alpha in Peri-Implant Crevicular Fluid: A Cross-Sectional Study.
    Title: The Influence of Genetic Polymorphisms on the Expression of Interleukin-1beta, Prostaglandin E2 and Tumor Necrosis Factor Alpha in Peri-Implant Crevicular Fluid: A Cross-Sectional Study.
  2. Elevated IL-1beta and Comparable IL-1 Receptor Antagonist Levels Are Characteristic Features of L-PRP in Female College Athletes Compared to Male Professional Soccer Players.
    Title: Elevated IL-1β and Comparable IL-1 Receptor Antagonist Levels Are Characteristic Features of L-PRP in Female College Athletes Compared to Male Professional Soccer Players.
  3. Association of MIF-173G/C, IL-4 VNTR, and IL-1RA VNTR variants with FMF-related amyloidosis in a Turkish cohort.
    Title: Association of MIF-173G/C, IL-4 VNTR, and IL-1RA VNTR variants with FMF-related amyloidosis in a Turkish cohort.
  4. DIA-based analysis of the menstrual blood proteome identifies association between CXCL5 and IL1RN and endometriosis.
    Title: DIA-based analysis of the menstrual blood proteome identifies association between CXCL5 and IL1RN and endometriosis.
  5. Investigating the relationship between the VNTR variant of the interleukin-1 receptor antagonist gene and coronary in-stent restenosis.
    Title: Investigating the relationship between the VNTR variant of the interleukin-1 receptor antagonist gene and coronary in-stent restenosis.
  6. IL-1RA promotes oral squamous cell carcinoma malignancy through mitochondrial metabolism-mediated EGFR/JNK/SOX2 pathway.
    Title: IL-1RA promotes oral squamous cell carcinoma malignancy through mitochondrial metabolism-mediated EGFR/JNK/SOX2 pathway.
  7. The role of genetic polymorphisms of interleukin-1 (IL-1R1 and IL-1RN) in primary knee osteoarthritis in Indonesia.
    Title: The role of genetic polymorphisms of interleukin-1 (IL-1R1 and IL-1RN) in primary knee osteoarthritis in Indonesia.
  8. IL-1RA inhibits esophageal carcinogenesis and lymphangiogenesis via downregulating VEGF-C and MMP9.
    Title: IL-1RA inhibits esophageal carcinogenesis and lymphangiogenesis via downregulating VEGF-C and MMP9.
  9. Tuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses.
    Title: Tuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses.
  10. An interleukin-1 polymorphism additionally intensified by atopy as prognostic factor for aseptic non-mechanical complications in metal knee and hip arthroplasty.
    Title: An interleukin-1 polymorphism additionally intensified by atopy as prognostic factor for aseptic non-mechanical complications in metal knee and hip arthroplasty.
Submit: New GeneRIF Correction See all GeneRIFs (560)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Gastric cancer
MedGen: C0024623 OMIM: 613659 GeneReviews: Not available
Compare labs
Microvascular complications of diabetes, susceptibility to, 4
MedGen: C2675112 OMIM: 612628 GeneReviews: Not available
Compare labs
Sterile multifocal osteomyelitis with periostitis and pustulosis
MedGen: C2748507 OMIM: 612852 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
A genome-wide association study identifies protein quantitative trait loci (pQTLs).
EBI GWAS Catalog
Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.
EBI GWAS Catalog
Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of interleukin 1 receptor antagonist (IL1RN) in human B cells PubMed
Tat tat HIV-1 Tat upregulates the expression of IL-1 receptor antagonist through binding to and inhibiting CD26 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC10430

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
  
enables interleukin-1 receptor antagonist activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables interleukin-1 receptor antagonist activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables interleukin-1 receptor antagonist activity TAS
Traceable Author Statement
more info
 PubMed 
enables interleukin-1 type I receptor antagonist activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables interleukin-1 type II receptor antagonist activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables interleukin-1, type I receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables interleukin-1, type II receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in immune response NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in inflammatory response to antigenic stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in insulin secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of heterotypic cell-cell adhesion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of interleukin-1-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of interleukin-1-mediated signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to glucocorticoid IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centrosome IDA
Inferred from Direct Assay
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in extracellular exosome HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
interleukin-1 receptor antagonist protein
Names
IL1 inhibitor
intracellular IL-1 receptor antagonist type II
intracellular interleukin-1 receptor antagonist (icIL-1ra)
type II interleukin-1 receptor antagonist

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021240.1 RefSeqGene

    Range
    5001..21124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_188

mRNA and Protein(s)

  1. NM_000577.5 → NP_000568.1  interleukin-1 receptor antagonist protein isoform 3

    See identical proteins and their annotated locations for NP_000568.1

    Status: REVIEWED

    Source sequence(s)
    AC024704, BC009745, M55646
    Consensus CDS
    CCDS2113.1
    UniProtKB/Swiss-Prot
    P18510
    Related
    ENSP00000329072.3, ENST00000354115.6
    Conserved Domains (1) summary
    smart00125
    Location:16 → 156
    IL1; Interleukin-1 homologues

  2. NM_001318914.2 → NP_001305843.1  interleukin-1 receptor antagonist protein isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC024704, AF043143, BC009745, DA667440
    Consensus CDS
    CCDS2115.1
    Related
    ENSP00000512949.1, ENST00000696881.1
    Conserved Domains (1) summary
    smart00125
    Location:1 → 140
    IL1; Interleukin-1 homologues

  3. NM_001379360.1 → NP_001366289.1  interleukin-1 receptor antagonist protein isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC024704
    Consensus CDS
    CCDS2115.1
    Related
    ENSP00000512947.1, ENST00000696879.1
    Conserved Domains (1) summary
    smart00125
    Location:1 → 140
    IL1; Interleukin-1 homologues

  4. NM_173841.3 → NP_776213.1  interleukin-1 receptor antagonist protein isoform 2

    See identical proteins and their annotated locations for NP_776213.1

    Status: REVIEWED

    Source sequence(s)
    AC024704
    Consensus CDS
    CCDS2114.1
    UniProtKB/Swiss-Prot
    P18510
    Related
    ENSP00000259206.5, ENST00000259206.9
    Conserved Domains (1) summary
    smart00125
    Location:37 → 177
    IL1; Interleukin-1 homologues

  5. NM_173842.3 → NP_776214.1  interleukin-1 receptor antagonist protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_776214.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' end compared to variant 2, resulting in an isoform (1) that has a distinct and shorter N-terminus, as compared to the longest isoform (2).
    Source sequence(s)
    AC024704, BC009745, BI766516
    Consensus CDS
    CCDS46396.1
    UniProtKB/Swiss-Prot
    A8K4G1, P18510, Q14628, Q53SC2, Q7RTZ4, Q96GD6, Q9UPC0
    Related
    ENSP00000387173.3, ENST00000409930.4
    Conserved Domains (1) summary
    smart00125
    Location:34 → 174
    IL1; Interleukin-1 homologues

  6. NM_173843.3 → NP_776215.1  interleukin-1 receptor antagonist protein isoform 4

    See identical proteins and their annotated locations for NP_776215.1

    Status: REVIEWED

    Source sequence(s)
    AC024704, AF043143, BC009745
    Consensus CDS
    CCDS2115.1
    Related
    ENSP00000354816.3, ENST00000361779.7
    Conserved Domains (1) summary
    smart00125
    Location:1 → 140
    IL1; Interleukin-1 homologues

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    113099360..113134014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047444184.1 → XP_047300140.1  interleukin-1 receptor antagonist protein isoform X1

  2. XM_047444185.1 → XP_047300141.1  interleukin-1 receptor antagonist protein isoform X1

  3. XM_011511121.2 → XP_011509423.1  interleukin-1 receptor antagonist protein isoform X1

    See identical proteins and their annotated locations for XP_011509423.1

    Related
    ENSP00000387210.1, ENST00000409052.6
    Conserved Domains (1) summary
    smart00125
    Location:1 → 140
    IL1; Interleukin-1 homologues

  4. XM_047444186.1 → XP_047300142.1  interleukin-1 receptor antagonist protein isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    113544556..113560594
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18510.1 GenPept UniProtKB/Swiss-Prot:P18510

Gene LinkOut

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