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RPA2 Replication protein A2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35364, updated on 27-Mar-2024

Summary

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Official Symbol
RPA2provided by FlyBase
Official Full Name
Replication protein A2provided by FlyBase
Primary source
FLYBASE:FBgn0288834
Locus tag
Dmel_CG9273
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
153194_at; CG9273; D-SSB; Dmel\CG9273; DmRP-A; DmRPA; dRP-A; DRP-A; dRPA2; RP-A; RPA; RPA 30 kDa; RpA-30; RpA2; RPA30; Ssb-30
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Genomic context

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Location:
38F6-38F6; 2-54 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20924975..20926147, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20924975..20926147, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Microsomal triacylglycerol transfer protein Neighboring gene pseudo Neighboring gene Nth-like DNA glycosylase 1 Neighboring gene pseudo Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitochondrial single-stranded DNA-binding protein from Drosophila embryos. Physical and biochemical characterization. Thömmes P, et al. J Biol Chem, 1995 Sep 8. PMID 7673145
  2. Onset of the DNA replication checkpoint in the early Drosophila embryo. Crest J, et al. Genetics, 2007 Feb. PMID 17151243, Free PMC Article
  3. Phosphorylation and localization of replication protein A during oogenesis and early embryogenesis of Drosophila melanogaster. Mitsis PG. Dev Biol, 1995 Aug. PMID 7649375
  4. Purification and characterisation of a DNA helicase, dheI I, from Drosophila melanogaster embryos. Thömmes P, et al. Nucleic Acids Res, 1995 Nov 11. PMID 7501468, Free PMC Article
  5. A new DNA polymerase species from Drosophila melanogaster: a probable mus308 gene product. Oshige M, et al. Mutat Res, 1999 Apr 9. PMID 10343651

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
replication protein A2
Names
CG9273-PA
CG9273-PB
RPA2-PA
RPA2-PB
drosophila replication protein A
replication protein A 30
replication protein A, subunit 2
single stranded-binding protein 30

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    20924975..20926147 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136233.3 → NP_610077.1  replication protein A2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610077.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C0MJ04, Q8T9K0, Q9VIH1
    Related
    FBpp0080967
    Conserved Domains (3) summary
    COG5235
    Location:12 → 246
    RFA2; Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit [DNA replication, recombination, and repair]
    cd04478
    Location:52 → 144
    RPA2_DBD_D; RPA2_DBD_D: A subfamily of OB folds corresponding to the OB fold of the central ssDNA-binding domain (DBD)-D of human RPA2 (also called RPA32). RPA2 is a subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears ...
    pfam08784
    Location:182 → 238
    RPA_C; Replication protein A C terminal

  2. NM_001273723.1 → NP_001260652.1  replication protein A2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260652.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C0MJ04, Q8T9K0, Q9VIH1
    Conserved Domains (3) summary
    COG5235
    Location:12 → 246
    RFA2; Single-stranded DNA-binding replication protein A (RPA), medium (30 kD) subunit [DNA replication, recombination, and repair]
    cd04478
    Location:52 → 144
    RPA2_DBD_D; RPA2_DBD_D: A subfamily of OB folds corresponding to the OB fold of the central ssDNA-binding domain (DBD)-D of human RPA2 (also called RPA32). RPA2 is a subunit of Replication protein A (RPA). RPA is a nuclear ssDNA-binding protein (SSB) which appears ...
    pfam08784
    Location:182 → 238
    RPA_C; Replication protein A C terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SXG3 Q8SXG3
Q9VIH1 Q9VIH1

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