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TICAM2 TIR domain containing adaptor molecule 2 [ Homo sapiens (human) ]

Gene ID: 353376, updated on 4-Jan-2025

Summary

Official Symbol
TICAM2provided by HGNC
Official Full Name
TIR domain containing adaptor molecule 2provided by HGNC
Primary source
HGNC:HGNC:21354
See related
Ensembl:ENSG00000243414 MIM:608321; AllianceGenome:HGNC:21354
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIRP; TRAM; TIRAP3; MyD88-4; TICAM-2
Summary
Enables molecular adaptor activity. Involved in several processes, including positive regulation of interleukin-18-mediated signaling pathway; regulation of cytokine production; and regulation of innate immune response. Located in endoplasmic reticulum; endosome; and phagocytic cup. Is active in endosome membrane. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in appendix (RPKM 4.0), spleen (RPKM 3.2) and 25 other tissues See more
Orthologs
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Genomic context

See TICAM2 in Genome Data Viewer
Location:
5q22.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (115578496..115602479, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (116091278..116115262, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (114914193..114938176, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene chaperonin containing TCP1 subunit 5 pseudogene 1 Neighboring gene fem-1 homolog C Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:114880021-114880787 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22934 Neighboring gene TMED7-TICAM2 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16252 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:114937526-114938048 Neighboring gene TICAM2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16254 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22936 Neighboring gene transmembrane p24 trafficking protein 7 Neighboring gene uncharacterized LOC102467217

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Readthrough TMED7-TICAM2

Readthrough gene: TMED7-TICAM2, Included gene: TMED7

Clone Names

  • MGC129876, MGC129877

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular adaptor activity PubMed 
enables protein binding PubMed 
enables signaling adaptor activity  
Process Evidence Code Pubs
involved_in TRAM-dependent toll-like receptor 4 signaling pathway PubMed 
involved_in TRAM-dependent toll-like receptor 4 signaling pathway PubMed 
involved_in TRIF-dependent toll-like receptor signaling pathway  
involved_in cellular response to lipopolysaccharide PubMed 
involved_in cellular response to lipopolysaccharide PubMed 
involved_in inflammatory response  
involved_in innate immune response  
involved_in negative regulation of chemokine (C-C motif) ligand 5 production PubMed 
involved_in negative regulation of toll-like receptor 4 signaling pathway PubMed 
involved_in phagocytosis PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction PubMed 
involved_in positive regulation of canonical NF-kappaB signal transduction  
involved_in positive regulation of chemokine (C-C motif) ligand 5 production PubMed 
involved_in positive regulation of interleukin-18-mediated signaling pathway PubMed 
involved_in positive regulation of toll-like receptor 4 signaling pathway PubMed 
involved_in positive regulation of toll-like receptor 4 signaling pathway PubMed 
involved_in positive regulation of type I interferon production  
involved_in positive regulation of type I interferon production PubMed 
involved_in toll-like receptor 4 signaling pathway PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus  
located_in cell projection  
located_in early endosome PubMed 
located_in early endosome membrane  
located_in endoplasmic reticulum PubMed 
located_in endoplasmic reticulum  
is_active_in endosome  
is_active_in endosome PubMed 
is_active_in endosome membrane PubMed 
located_in endosome membrane  
located_in late endosome PubMed 
located_in late endosome membrane  
located_in phagocytic cup PubMed 
located_in plasma membrane PubMed 
located_in plasma membrane  
located_in secretory granule membrane  

General protein information

Preferred Names
TIR domain-containing adapter molecule 2
Names
NF-kappa-B-activating protein 502
TRIF-related adaptor molecule
cytoplasmic adaptor
putative NF-kappa-B-activating protein 502
toll like receptor adaptor molecule 2
toll-like receptor adaptor protein 3
toll/interleukin-1 receptor (TIR) domain-containing adapter protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021649.7NP_067681.1  TIR domain-containing adapter molecule 2

    See identical proteins and their annotated locations for NP_067681.1

    Status: VALIDATED

    Source sequence(s)
    AB097022, AC010226, DA092564, DA992598
    Consensus CDS
    CCDS4119.1
    UniProtKB/Swiss-Prot
    B3Y698, Q6JUT2, Q86XR7
    Related
    ENSP00000415139.3, ENST00000427199.3
    Conserved Domains (1) summary
    cl23749
    Location:81172
    TIR_2; TIR domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    115578496..115602479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    116091278..116115262 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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