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Eras ES cell-expressed Ras [ Mus musculus (house mouse) ]

Gene ID: 353283, updated on 11-Apr-2024

Summary

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Official Symbol
Erasprovided by MGI
Official Full Name
ES cell-expressed Rasprovided by MGI
Primary source
MGI:MGI:2665023
See related
Ensembl:ENSMUSG00000031160 AllianceGenome:MGI:2665023
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HRAS2; HRasp; ecat5; Ha-Ras2
Summary
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including blastocyst; early embryo; embryo ectoderm; embryo mesoderm; and primitive streak. Orthologous to human ERAS (ES cell expressed Ras). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cortex adult (RPKM 83.1), cerebellum adult (RPKM 64.9) and 3 other tissues See more
Orthologs
human all
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Genomic context

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See Eras in Genome Data Viewer
Location:
X A1.1; X 3.58 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (7790515..7794846, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (7924276..7928607, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7684 Neighboring gene polyglutamine binding protein 1 Neighboring gene translocase of inner mitochondrial membrane 17b Neighboring gene STARR-seq mESC enhancer starr_46677 Neighboring gene proprotein convertase subtilisin/kexin type 1 inhibitor Neighboring gene histone deacetylase 6 Neighboring gene STARR-seq mESC enhancer starr_46678 Neighboring gene STARR-seq mESC enhancer starr_46679 Neighboring gene predicted gene, 39488 Neighboring gene proteasome (prosome, macropain) subunit, beta type 6, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A novel rasH2 mouse carcinogenesis model that is highly susceptible to 4-NQO-induced tongue and esophageal carcinogenesis is useful for preclinical chemoprevention studies. Miyamoto S, et al. Carcinogenesis, 2008 Feb. PMID 18174262
  2. Differential membrane localization of ERas and Rheb, two Ras-related proteins involved in the phosphatidylinositol 3-kinase/mTOR pathway. Takahashi K, et al. J Biol Chem, 2005 Sep 23. PMID 16046393
  3. The Ras-related gene ERAS is involved in human and murine breast cancer. Suárez-Cabrera C, et al. Sci Rep, 2018 Aug 29. PMID 30158566, Free PMC Article
  4. The roles of ERAS during cell lineage specification of mouse early embryonic development. Zhao ZA, et al. Open Biol, 2015 Aug. PMID 26269429, Free PMC Article
  5. Stimulation of somatic cell reprogramming by ERas-Akt-FoxO1 signaling axis. Yu Y, et al. Stem Cells, 2014 Feb. PMID 23765875

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ERAS may also play important roles in cell lineage specification during mouse early embryonic development.
    Title: The roles of ERAS during cell lineage specification of mouse early embryonic development.
  2. Collectively, these results unravel the significance of the ERas-Akt-FoxO1 signaling axis in iPSC generation, suggesting a possibly shared molecular basis for both somatic reprogramming and cancer initiation
    Title: Stimulation of somatic cell reprogramming by ERas-Akt-FoxO1 signaling axis.
  3. galectin-1 increased DNA synthesis in mouse ES cells via Src, caveolin-1 Akt, and mTOR signaling pathways
    Title: Interaction of galectin-1 with caveolae induces mouse embryonic stem cell proliferation through the Src, ERas, Akt and mTOR signaling pathways.
  4. rasH2 may have a role in susceptibility to chemically-induced tongue and esophageal neoplasms
    Title: A novel rasH2 mouse carcinogenesis model that is highly susceptible to 4-NQO-induced tongue and esophageal carcinogenesis is useful for preclinical chemoprevention studies.
  5. ERas and Rheb are two Ras-related proteins involved in the phosphatidylinositol 3-kinase/mTOR pathway; ERas is localized at the plasma membrane, while Rheb is on endomembranes.
    Title: Differential membrane localization of ERas and Rheb, two Ras-related proteins involved in the phosphatidylinositol 3-kinase/mTOR pathway.
  6. transforming oncogene ERas is important in the tumour-like growth properties of embryonic stem cells
    Title: Role of ERas in promoting tumour-like properties in mouse embryonic stem cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GDP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
GTPase ERas
Names
E-Ras
embryonic stem cell-expressed Ras
small GTPase E-Ras
NP_853526.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181548.2 → NP_853526.1  GTPase ERas

    See identical proteins and their annotated locations for NP_853526.1

    Status: PROVISIONAL

    Source sequence(s)
    AB093573
    Consensus CDS
    CCDS29980.1
    UniProtKB/Swiss-Prot
    Q7TN89
    UniProtKB/TrEMBL
    Q0VEC9
    Related
    ENSMUSP00000033500.5, ENSMUST00000033500.5
    Conserved Domains (2) summary
    smart00010
    Location:40 → 201
    small_GTPase; Small GTPase of the Ras superfamily; ill-defined subfamily
    cl21455
    Location:42 → 201
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    7790515..7794846 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TN89.1 GenPept UniProtKB/Swiss-Prot:Q7TN89

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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