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Gtf2i general transcription factor II I [ Rattus norvegicus (Norway rat) ]

Gene ID: 353256, updated on 13-Apr-2024

Summary

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Official Symbol
Gtf2iprovided by RGD
Official Full Name
general transcription factor II Iprovided by RGD
Primary source
RGD:727961
See related
Ensembl:ENSRNOG00000001479 AllianceGenome:RGD:727961
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Gtf2ird1
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and mitogen-activated protein kinase binding activity. Involved in negative regulation of cytosolic calcium ion concentration. Predicted to be located in cell projection; neuronal cell body; and nucleoplasm. Predicted to be active in nucleus. Orthologous to human GTF2I (general transcription factor IIi). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 287.1), Adrenal (RPKM 284.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gtf2i in Genome Data Viewer
Location:
12q12
Exon count:
39
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (28037344..28112677)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (22400933..22476243)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (25410804..25487970)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene CAP-GLY domain containing linker protein 2 Neighboring gene GTF2I repeat domain containing 1 Neighboring gene GTF2I repeat domain containing 2 Neighboring gene neutrophil cytosolic factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Novel splice variants in the 5'UTR of Gtf2i expressed in the rat brain: alternative 5'UTRs and differential expression in the neuronal dendrites. Shirai Y, et al. J Neurochem, 2015 Aug. PMID 25913238
  2. Opposing functions of TFII-I spliced isoforms in growth factor-induced gene expression. Hakre S, et al. Mol Cell, 2006 Oct 20. PMID 17052463
  3. TFII-I, a candidate gene for Williams syndrome cognitive profile: parallels between regional expression in mouse brain and human phenotype. Danoff SK, et al. Neuroscience, 2004. PMID 14751286
  4. Essential functions of the Williams-Beuren syndrome-associated TFII-I genes in embryonic development. Enkhmandakh B, et al. Proc Natl Acad Sci U S A, 2009 Jan 6. PMID 19109438, Free PMC Article
  5. Positional identification of Ncf1 as a gene that regulates arthritis severity in rats. Olofsson P, et al. Nat Genet, 2003 Jan. PMID 12461526

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We identified seven novel Gtf2i transcripts with alternatively spliced 5'UTRs in the rat brain. In situ hybridization demonstrated a differential
    Title: Novel splice variants in the 5'UTR of Gtf2i expressed in the rat brain: alternative 5'UTRs and differential expression in the neuronal dendrites.
  2. observations suggest a model in which TFII-I suppresses agonist-induced calcium entry by competing with TRPC3 for binding to phospholipase C-gamma
    Title: Action of TFII-I outside the nucleus as an inhibitor of agonist-induced calcium entry.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC94055

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables mitogen-activated protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cytosolic calcium ion concentration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transition between slow and fast fiber ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
general transcription factor II-I
Names
GTFII-I
TFII-I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001512.3 → NP_001001512.2  general transcription factor II-I isoform 1

    See identical proteins and their annotated locations for NP_001001512.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A0A1B0GWN0
    Related
    ENSRNOP00000040835.2, ENSRNOT00000040356.6
    Conserved Domains (1) summary
    pfam02946
    Location:112 → 184
    GTF2I; GTF2I-like repeat

  2. NM_001401209.1 → NP_001388138.1  general transcription factor II-I isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/Swiss-Prot
    Q5U2Y1, Q80SX4
    UniProtKB/TrEMBL
    A6J0K2
    Related
    ENSRNOP00000002020.3, ENSRNOT00000002020.7

  3. NM_001401210.1 → NP_001388139.1  general transcription factor II-I isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000012
    UniProtKB/TrEMBL
    A0A8I6ALH4
    Related
    ENSRNOP00000095456.1, ENSRNOT00000109966.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    28037344..28112677
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063271417.1 → XP_063127487.1  general transcription factor II-I isoform X6

    UniProtKB/TrEMBL
    A0A8I6ALH4

  2. XM_063271421.1 → XP_063127491.1  general transcription factor II-I isoform X9

    UniProtKB/TrEMBL
    A0A8I5ZRM5

  3. XM_008769141.3 → XP_008767363.1  general transcription factor II-I isoform X1

    See identical proteins and their annotated locations for XP_008767363.1

    UniProtKB/TrEMBL
    A0A0G2K4T7, A0A1B0GWN0
    Conserved Domains (1) summary
    pfam02946
    Location:112 → 184
    GTF2I; GTF2I-like repeat

  4. XM_006249170.5 → XP_006249232.1  general transcription factor II-I isoform X1

    See identical proteins and their annotated locations for XP_006249232.1

    UniProtKB/TrEMBL
    A0A0G2K4T7, A0A1B0GWN0
    Related
    ENSRNOP00000073166.1
    Conserved Domains (1) summary
    pfam02946
    Location:112 → 184
    GTF2I; GTF2I-like repeat

  5. XM_063271418.1 → XP_063127488.1  general transcription factor II-I isoform X7

    UniProtKB/TrEMBL
    A6J0K4

  6. XM_063271419.1 → XP_063127489.1  general transcription factor II-I isoform X9

    UniProtKB/TrEMBL
    A0A8I5ZRM5

  7. XM_063271420.1 → XP_063127490.1  general transcription factor II-I isoform X9

    UniProtKB/TrEMBL
    A0A8I5ZRM5

  8. XM_063271416.1 → XP_063127486.1  general transcription factor II-I isoform X6

    UniProtKB/TrEMBL
    A0A8I6ALH4

  9. XM_063271413.1 → XP_063127483.1  general transcription factor II-I isoform X1

    UniProtKB/TrEMBL
    A0A0G2K4T7

  10. XM_063271415.1 → XP_063127485.1  general transcription factor II-I isoform X3

    UniProtKB/Swiss-Prot
    Q5U2Y1, Q80SX4
    UniProtKB/TrEMBL
    A6J0K2

  11. XM_063271410.1 → XP_063127480.1  general transcription factor II-I isoform X6

    UniProtKB/TrEMBL
    A0A8I6ALH4

  12. XM_063271408.1 → XP_063127478.1  general transcription factor II-I isoform X1

    UniProtKB/TrEMBL
    A0A0G2K4T7

  13. XM_017598362.3 → XP_017453851.1  general transcription factor II-I isoform X4

    UniProtKB/TrEMBL
    A0A1B0GWN0, A0A8I6AST1
    Related
    ENSRNOP00000096595.1

  14. XM_017598360.3 → XP_017453849.1  general transcription factor II-I isoform X2

    UniProtKB/TrEMBL
    A0A1B0GWN0, A6J0J9
    Conserved Domains (1) summary
    pfam02946
    Location:112 → 184
    GTF2I; GTF2I-like repeat

  15. XM_017598363.3 → XP_017453852.1  general transcription factor II-I isoform X5

    UniProtKB/TrEMBL
    A0A1B0GWN0, A6J0K0
    Conserved Domains (1) summary
    pfam02946
    Location:112 → 184
    GTF2I; GTF2I-like repeat

  16. XM_063271409.1 → XP_063127479.1  general transcription factor II-I isoform X3

    UniProtKB/Swiss-Prot
    Q5U2Y1, Q80SX4
    UniProtKB/TrEMBL
    A6J0K2

  17. XM_063271411.1 → XP_063127481.1  general transcription factor II-I isoform X7

    UniProtKB/TrEMBL
    A6J0K4

  18. XM_063271414.1 → XP_063127484.1  general transcription factor II-I isoform X9

    UniProtKB/TrEMBL
    A0A8I5ZRM5

  19. XM_017598366.3 → XP_017453855.1  general transcription factor II-I isoform X8

    UniProtKB/TrEMBL
    A0A1B0GWN0, A0A8I5ZK83
    Related
    ENSRNOP00000077117.1

  20. XM_017598370.3 → XP_017453859.1  general transcription factor II-I isoform X11

    UniProtKB/TrEMBL
    A0A1B0GWN0

  21. XM_017598369.3 → XP_017453858.1  general transcription factor II-I isoform X10

    UniProtKB/TrEMBL
    A0A1B0GWN0

  22. XM_039089536.2 → XP_038945464.1  general transcription factor II-I isoform X12

    Conserved Domains (1) summary
    pfam02946
    Location:200 → 274
    GTF2I; GTF2I-like repeat

  23. XM_039089537.2 → XP_038945465.1  general transcription factor II-I isoform X13

    Conserved Domains (1) summary
    pfam02946
    Location:179 → 253
    GTF2I; GTF2I-like repeat
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5U2Y1.2 GenPept UniProtKB/Swiss-Prot:Q5U2Y1

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