U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rdh10 retinol dehydrogenase 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 353252, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Rdh10provided by RGD
Official Full Name
retinol dehydrogenase 10provided by RGD
Primary source
RGD:727793
See related
Ensembl:ENSRNOG00000006681 AllianceGenome:RGD:727793
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable NAD-retinol dehydrogenase activity. Involved in positive regulation of retinoic acid biosynthetic process. Located in intracellular membrane-bounded organelle. Orthologous to human RDH10 (retinol dehydrogenase 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 180.5), Kidney (RPKM 145.4) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
5q11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (7969931..7998834, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (3186671..3215572, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (2605265..2631905, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486907 Neighboring gene staufen double-stranded RNA binding protein 2 Neighboring gene uncharacterized LOC102555040 Neighboring gene uncharacterized LOC134486911 Neighboring gene similar to human chromosome 8 open reading frame 89 Neighboring gene ribosomal protein L7

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of RDH10, an All-trans Retinol Dehydrogenase, in Retinal Muller Cells. Wu BX, et al. Invest Ophthalmol Vis Sci, 2004 Nov. PMID 15505029
  2. The 11-cis-retinol dehydrogenase activity of RDH10 and its interaction with visual cycle proteins. Farjo KM, et al. Invest Ophthalmol Vis Sci, 2009 Nov. PMID 19458327
  3. Cloning and characterization of a novel all-trans retinol short-chain dehydrogenase/reductase from the RPE. Wu BX, et al. Invest Ophthalmol Vis Sci, 2002 Nov. PMID 12407145
  4. Multiple retinol and retinal dehydrogenases catalyze all-trans-retinoic acid biosynthesis in astrocytes. Wang C, et al. J Biol Chem, 2011 Feb 25. PMID 21138835, Free PMC Article
  5. Key enzymes of the retinoid (visual) cycle in vertebrate retina. Kiser PD, et al. Biochim Biophys Acta, 2012 Jan. PMID 21447403, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables all-trans-retinol dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
enables all-trans-retinol dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within bud elongation involved in lung branching ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ear development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic camera-type eye development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic forelimb morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic organ development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within embryonic viscerocranium morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within gonad development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within metanephros development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neural crest cell development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nose development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of retinoic acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within primary lung bud formation ISO
Inferred from Sequence Orthology
more info
  
involved_in retinal metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within retinoic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in retinol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in retinol metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within visual perception ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in lipid droplet IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
NOT located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
retinol dehydrogenase 10
Names
retinol dehydrogenase 10 (all-trans)
NP_852143.1
XP_038966079.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181478.2 → NP_852143.1  retinol dehydrogenase 10

    See identical proteins and their annotated locations for NP_852143.1

    Status: PROVISIONAL

    Source sequence(s)
    AY178865
    UniProtKB/Swiss-Prot
    Q80ZF7
    UniProtKB/TrEMBL
    A6JFB5
    Related
    ENSRNOP00000009096.2, ENSRNOT00000009096.5
    Conserved Domains (1) summary
    cd05339
    Location:38 → 307
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    7969931..7998834 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110151.2 → XP_038966079.1  retinol dehydrogenase 10 isoform X1

    Conserved Domains (1) summary
    cd05339
    Location:1 → 142
    17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80ZF7.1 GenPept UniProtKB/Swiss-Prot:Q80ZF7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous