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Nsmaf neutral sphingomyelinase activation associated factor [ Rattus norvegicus (Norway rat) ]

Gene ID: 353233, updated on 13-Apr-2024

Summary

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Official Symbol
Nsmafprovided by RGD
Official Full Name
neutral sphingomyelinase activation associated factorprovided by RGD
Primary source
RGD:727868
See related
Ensembl:ENSRNOG00000010234 AllianceGenome:RGD:727868
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
FAN
Summary
Enables sphingomyelin phosphodiesterase activator activity. Involved in positive regulation of apoptotic process. Orthologous to human NSMAF (neutral sphingomyelinase activation associated factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 176.6), Spleen (RPKM 146.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q12
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (24315319..24378346, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (19517795..19578773, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (19499111..19560308, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 epsilon-1-like Neighboring gene syndecan binding protein Neighboring gene uncharacterized LOC134478929 Neighboring gene G3BP stress granule assembly factor 1, pseudogene 2 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Factor associated with neutral sphingomyelinase activation and its role in cardiac cell death. O'Brien NW, et al. Circ Res, 2003 Apr 4. PMID 12637370
  2. Neutral sphingomyelinase, NADPH oxidase and reactive oxygen species. Role in acute hypoxic pulmonary vasoconstriction. Frazziano G, et al. J Cell Physiol, 2011 Oct. PMID 21792922
  3. The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase. Lei X, et al. Biochemistry, 2007 Sep 4. PMID 17685585, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We propose an integrated signalling pathway for hypoxic pulmonary vasoconstriction which includes nSMase-PKCzeta-NADPH oxidase as a necessary step required for reactive oxygen species production.
    Title: Neutral sphingomyelinase, NADPH oxidase and reactive oxygen species. Role in acute hypoxic pulmonary vasoconstriction.
  2. These findings indicate that iPLA2beta activation participates in ER stress-induced INS-1 cell apoptosis by promoting ceramide generation via NSMase-catalyzed hydrolysis of sphingomyelins
    Title: The group VIA calcium-independent phospholipase A2 participates in ER stress-induced INS-1 insulinoma cell apoptosis by promoting ceramide generation via hydrolysis of sphingomyelins by neutral sphingomyelinase.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables sphingomyelin phosphodiesterase activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of amide metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of lipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of membrane lipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
protein FAN
Names
factor associated with neutral sphingomyelinase activation
neutral sphingomyelinase (N-SMase) activation associated factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181389.3 → NP_852054.2  protein FAN

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    F1M974, Q7TSY5
    Related
    ENSRNOP00000014289.7, ENSRNOT00000014289.7
    Conserved Domains (4) summary
    cd00200
    Location:625 → 917
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:636 → 673
    7WD40; WD40 repeat [structural motif]
    pfam02138
    Location:304 → 575
    Beach; Beige/BEACH domain
    cl17171
    Location:192 → 285
    PH-like; Pleckstrin homology-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    24315319..24378346 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287865.1 → XP_063143935.1  protein FAN isoform X1

  2. XM_063287867.1 → XP_063143937.1  protein FAN isoform X1

  3. XM_063287866.1 → XP_063143936.1  protein FAN isoform X1

  4. XM_039110149.2 → XP_038966077.1  protein FAN isoform X2

    UniProtKB/TrEMBL
    Q7TSY5
    Conserved Domains (4) summary
    sd00039
    Location:637 → 673
    7WD40; WD40 repeat [structural motif]
    pfam02138
    Location:304 → 575
    Beach; Beige/BEACH domain
    cl17171
    Location:192 → 285
    PH-like; Pleckstrin homology-like domain
    cl29593
    Location:617 → 743
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  5. XM_039110150.2 → XP_038966078.1  protein FAN isoform X3

    UniProtKB/TrEMBL
    A6JFP4
    Conserved Domains (2) summary
    pfam02138
    Location:304 → 575
    Beach; Beige/BEACH domain
    cl17171
    Location:192 → 285
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein Strain
Heading Accession and Version

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