mc1r melanocortin 1 receptor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mc1rprovided by ZNC
Official Full Name: melanocortin 1 receptorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030502-1
See related: Ensembl:ENSDARG00000020237 AllianceGenome:ZFIN:ZDB-GENE-030502-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Predicted to enable melanocyte-stimulating hormone receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in plasma membrane. Is expressed in several structures, including endocrine system; female organism; integument; male organism; and nervous system. Human ortholog(s) of this gene implicated in familial melanoma; major depressive disorder; melanoma; oculocutaneous albinism type II; and pigmentation disease. Orthologous to human MC1R (melanocortin 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 18

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (31226034..31227821, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (31247741..31249393, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

loss-of-function of mc1r causes a reduction of countershading and a general paling of the animals.
Title: Loss-of-function mutations in the melanocortin 1 receptor cause disruption of dorso-ventral countershading in teleost fish.
This study demonstrated a direct role for mc1r in zebrafish melanosome dispersal in response to background, and used chemical modification of this pathway to uncover a possible new layer of regulation in melanosome dispersal in zebrafish.
Title: mc1r Pathway regulation of zebrafish melanosome dispersion.
Evolution of mc1r in zebrafish is reported.
Title: Evolution of melanocortin receptors in teleost fish: the melanocortin type 1 receptor.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables melanocortin receptor activity	IEA Inferred from Electronic Annotation more info
enables melanocyte-stimulating hormone receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables melanocyte-stimulating hormone receptor activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: melanocyte-stimulating hormone receptor

Names: melanocortin 1 receptor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_180970.1 → NP_851301.1 melanocyte-stimulating hormone receptor

See identical proteins and their annotated locations for NP_851301.1

Status: PROVISIONAL

Source sequence(s)

AY161847

UniProtKB/TrEMBL

B3DHP2, Q7ZTA3

Related

ENSDARP00000008075.6, ENSDART00000003210.8

Conserved Domains (2) summary

pfam00001
Location:60 → 300

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:50 → 186

7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007129.7 Reference GRCz11 Primary Assembly

Range

31226034..31227821 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005159179.4 → XP_005159236.1 melanocyte-stimulating hormone receptor isoform X1

See identical proteins and their annotated locations for XP_005159236.1

UniProtKB/TrEMBL

B3DHP2, Q7ZTA3

Conserved Domains (2) summary

pfam00001
Location:60 → 300

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:50 → 186

7tm_4; Olfactory receptor