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STAT6 signal transducer and activator of transcription 6 [ Bos taurus (cattle) ]

Gene ID: 353105, updated on 11-Apr-2024

Summary

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Official Symbol
STAT6provided by VGNC
Official Full Name
signal transducer and activator of transcription 6provided by VGNC
Primary source
VGNC:VGNC:35374
See related
BGD:BT12329; Ensembl:ENSBTAG00000006335
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 5 NC_037332.1 (56326256..56340447)

Chromosome 5 - NC_037332.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC132345298 Neighboring gene small nucleolar RNA SNORA62/SNORA6 family Neighboring gene microRNA mir-2431 Neighboring gene NGFI-A binding protein 2 Neighboring gene glycine cleavage system protein H pseudogene Neighboring gene nuclear envelope integral membrane protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037332.1 Chromosome 5 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Polymorphisms in the STAT6 gene and their association with carcass traits in feedlot cattle. Rincon G, et al. Anim Genet, 2009 Dec. PMID 19519791
  2. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results provide evidence that polymorphisms in STAT6 are associated with carcass and growth efficiency traits
    Title: Polymorphisms in the STAT6 gene and their association with carcass traits in feedlot cattle.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in growth hormone receptor signaling pathway via JAK-STAT IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to peptide hormone IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
signal transducer and activator of transcription 6
Names
signal transducer and activator of transcription 6, interleukin-4 induced

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001205501.1 → NP_001192430.1  signal transducer and activator of transcription 6

    See identical proteins and their annotated locations for NP_001192430.1

    Status: PROVISIONAL

    Source sequence(s)
    NKLS02000005
    UniProtKB/TrEMBL
    F1MGJ4
    Conserved Domains (5) summary
    cd10377
    Location:517 → 646
    SH2_STAT6; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 6 proteins
    smart00964
    Location:2 → 115
    STAT_int; STAT protein, protein interaction domain
    pfam14596
    Location:655 → 847
    STAT6_C; STAT6 C-terminal
    pfam01017
    Location:178 → 271
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:273 → 526
    STAT_bind; STAT protein, DNA binding domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037332.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    56326256..56340447
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024991408.2 → XP_024847176.1  signal transducer and activator of transcription 6 isoform X1

    UniProtKB/TrEMBL
    F1MGJ4
    Conserved Domains (5) summary
    cd10377
    Location:517 → 646
    SH2_STAT6; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 6 proteins
    smart00964
    Location:2 → 115
    STAT_int; STAT protein, protein interaction domain
    pfam14596
    Location:655 → 847
    STAT6_C; STAT6 C-terminal
    pfam01017
    Location:178 → 271
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:273 → 526
    STAT_bind; STAT protein, DNA binding domain

  2. XM_005206514.5 → XP_005206571.1  signal transducer and activator of transcription 6 isoform X1

    See identical proteins and their annotated locations for XP_005206571.1

    UniProtKB/TrEMBL
    F1MGJ4
    Related
    ENSBTAP00000008311.5, ENSBTAT00000008311.7
    Conserved Domains (5) summary
    cd10377
    Location:517 → 646
    SH2_STAT6; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 6 proteins
    smart00964
    Location:2 → 115
    STAT_int; STAT protein, protein interaction domain
    pfam14596
    Location:655 → 847
    STAT6_C; STAT6 C-terminal
    pfam01017
    Location:178 → 271
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:273 → 526
    STAT_bind; STAT protein, DNA binding domain

  3. XM_059886138.1 → XP_059742121.1  signal transducer and activator of transcription 6 isoform X2

  4. XM_024991412.2 → XP_024847180.1  signal transducer and activator of transcription 6 isoform X3

    Conserved Domains (5) summary
    cd10377
    Location:466 → 595
    SH2_STAT6; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 6 proteins
    pfam14596
    Location:604 → 796
    STAT6_C; STAT6 C-terminal
    pfam01017
    Location:127 → 220
    STAT_alpha; STAT protein, all-alpha domain
    pfam02864
    Location:222 → 475
    STAT_bind; STAT protein, DNA binding domain
    cl03749
    Location:2 → 64
    STAT_int; STAT protein, protein interaction domain
Nucleotide Protein Strain
Heading Accession and Version

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