tph1a tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tph1aprovided by ZNC
Official Full Name: tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030317-1
See related: Ensembl:ENSDARG00000029432 AllianceGenome:ZFIN:ZDB-GENE-030317-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: tph; tph1; tphD1; tph1-1
Summary: Predicted to enable tryptophan 5-monooxygenase activity. Acts upstream of or within regulation of hematopoietic stem cell differentiation. Predicted to be active in neuron projection. Is expressed in nervous system; neural tube; and ovary. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; borderline personality disorder; mental depression (multiple); and scoliosis. Orthologous to human TPH1 (tryptophan hydroxylase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (8139220..8160012, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (8014884..8035920, complement)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Disruption of tph1 genes demonstrates the importance of serotonin in regulating ventilation in larval zebrafish (Danio rerio).
Title: Disruption of tph1 genes demonstrates the importance of serotonin in regulating ventilation in larval zebrafish (Danio rerio).
DNA Methylation Profiles of Tph1A and BDNF in Gut and Brain of L. Rhamnosus-Treated Zebrafish.
Title: DNA Methylation Profiles of Tph1A and BDNF in Gut and Brain of L. Rhamnosus-Treated Zebrafish.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen	IEA Inferred from Electronic Annotation more info
enables tryptophan 5-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tryptophan 5-monooxygenase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within aromatic amino acid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of hematopoietic stem cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within serotonin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in serotonin biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tryptophan 5-hydroxylase 1; tryptophan 5-hydroxylase 1a

Names: tryptophan hydroxylase (tryptophan 5-monooxygenase

NP_840091.2

EC 1.14.16.4

XP_017209547.1

EC 1.14.16.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178306.3 → NP_840091.2 tryptophan 5-hydroxylase 1a

See identical proteins and their annotated locations for NP_840091.2

Status: PROVISIONAL

Source sequence(s)

BC059550

UniProtKB/TrEMBL

A0A8M1PC40, Q6PBX4

Related

ENSDARP00000067158.4, ENSDART00000067159.6

Conserved Domains (3) summary

TIGR01270
Location:50 → 478

Trp_5_monoox; tryptophan 5-monooxygenase, tetrameric

cd04929
Location:57 → 130

ACT_TPH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes

pfam00351
Location:145 → 475

Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase