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gpx4a glutathione peroxidase 4a [ Danio rerio (zebrafish) ]

Gene ID: 352928, updated on 27-Mar-2024

Summary

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Official Symbol
gpx4aprovided by ZNC
Official Full Name
glutathione peroxidase 4aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030410-2
See related
Ensembl:ENSDARG00000068478 AllianceGenome:ZFIN:ZDB-GENE-030410-2
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb563; cb691; PHGPxa; sb:cb563; zgc:92253; wu:fb82e03
Summary
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of hydrogen peroxide, organic hydroperoxides and lipid hydroperoxides, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme has a high preference for lipid hydroperoxides and protects cells against membrane lipid peroxidation and cell death. It is also required for normal sperm development. This isozyme is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. A paralog of this gene is present on chromosome 2. Each paralog has a distinct pattern of expression during embryonic development. [provided by RefSeq, Aug 2017]
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 22
Exon count:
8
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 22 NC_007133.7 (17589608..17597002, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 22 NC_007133.6 (17564630..17570315, complement)

Chromosome 22 - NC_007133.7Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein M Neighboring gene phosphatidylinositol-4-phosphate 5-kinase, type I, gamma a Neighboring gene RNA polymerase II, I and III subunit E, b Neighboring gene Rho GTPase activating protein 45b

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Spatial and temporal expression of zebrafish glutathione peroxidase 4 a and b genes during early embryo development. Mendieta-Serrano MA, et al. Gene Expr Patterns, 2015 Sep-Nov. PMID 26315538
  2. Molecular characterization and mRNA expression of glutathione peroxidase and glutathione S-transferase during osmotic stress in olive flounder (Paralichthys olivaceus). Choi CY, et al. Comp Biochem Physiol A Mol Integr Physiol, 2008 Mar. PMID 18302988
  3. Parental trophic exposure to three aromatic fractions of polycyclic aromatic hydrocarbons in the zebrafish: Consequences for the offspring. Perrichon P, et al. Sci Total Environ, 2015 Aug 15. PMID 25889544
  4. Zebrafish (Danio rerio) fed vitamin E-deficient diets produce embryos with increased morphologic abnormalities and mortality. Miller GW, et al. J Nutr Biochem, 2012 May. PMID 21684137, Free PMC Article
  5. Hinokitiol functions as a ferroptosis inhibitor to confer neuroprotection. Xi J, et al. Free Radic Biol Med, 2022 Sep. PMID 35985562

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables glutathione peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid-hydroperoxide glutathione peroxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within response to oxidative stress IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glutathione peroxidase 4a
NP_001007283.2
NP_001333466.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007282.2 → NP_001007283.2  glutathione peroxidase 4a isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon and uses an alternate translation start site compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    EH582507, EH584097
    UniProtKB/TrEMBL
    A0A8M1N2T9
    Related
    ENSDARP00000089830.4, ENSDART00000099056.5
    Conserved Domains (1) summary
    cd00340
    Location:29 → 182
    GSH_Peroxidase; Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per ...

  2. NM_001346537.1 → NP_001333466.1  glutathione peroxidase 4a isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript, and encodes the longer isoform (1).
    Source sequence(s)
    EH454234, EH584097
    UniProtKB/TrEMBL
    A0A8M1PAF3

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007133.7 Reference GRCz11 Primary Assembly

    Range
    17589608..17597002 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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