selenot1a selenoprotein T, 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: selenot1aprovided by ZNC
Official Full Name: selenoprotein T, 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030327-6
See related: Ensembl:ENSDARG00000058354 AllianceGenome:ZFIN:ZDB-GENE-030327-6
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cb700; selt1a; sept1a; wu:fb63h09; wu:fc79a12
Summary: This gene encodes a selenoprotein, containing a selenocysteine (Sec) residue at the active site. Sec is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs in vertebrates contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is localized in the endoplasmic reticulum. It belongs to the SelWTH family that possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Paralogs of this gene are found on chromosomes 18 (GeneID:352921) and 14 (GeneID:352917). [provided by RefSeq, Aug 2017]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (9684305..9696323, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (9886485..9898503, complement)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AI497309 (e-PCR)
- UniSTS:206352

AI496880 (e-PCR)
- UniSTS:206391

fc79a12.x1 (e-PCR)
- UniSTS:188283

fb64h09 (e-PCR)
- UniSTS:189062

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables thioredoxin-disulfide reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info
enables thioredoxin-disulfide reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell redox homeostasis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: thioredoxin reductase-like selenoprotein T1a

Names: thioredoxin reductase-like enzyme

NP_840075.2

EC 1.8.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178290.6 → NP_840075.2 thioredoxin reductase-like selenoprotein T1a precursor

Status: REVIEWED

Source sequence(s)

BC054578, CB359649, EH438162, EH473273

UniProtKB/Swiss-Prot

Q0Z8S3, Q802F2

Related

ENSDARP00000136996.1, ENSDART00000165712.2

Conserved Domains (1) summary

TIGR02174
Location:42 → 180

CXXU_selWTH; selT/selW/selH selenoprotein domain