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Rpn3 Regulatory particle non-ATPase 3 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35176, updated on 5-May-2024

Summary

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Official Symbol
Rpn3provided by FlyBase
Official Full Name
Regulatory particle non-ATPase 3provided by FlyBase
Primary source
FLYBASE:FBgn0261396
Locus tag
Dmel_CG42641
See related
AllianceGenome:FB:FBgn0261396
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10484; CG42641; Dmel\CG42641; Dox; Dox-A2; DoxA2; DXA2_DROME; l(2)37Bf; l(2)37Bf[+]; p58; RPN3; S3
Old locus tag
Dmel_CG10484
Summary
Enables zinc ion binding activity. Predicted to be involved in ubiquitin-dependent protein catabolic process. Part of proteasome regulatory particle. Is expressed in adult head and adult heart. Orthologous to human PSMD3 (proteasome 26S subunit, non-ATPase 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
37B12-37B12; 2-54 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19051790..19053681)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19051790..19053681)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Acinus Neighboring gene uncharacterized protein Neighboring gene lethal (2) 37Bb Neighboring gene uncharacterized protein Neighboring gene PH domain leucine-rich repeat protein phosphatase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A diphenol oxidase gene is part of a cluster of genes involved in catecholamine metabolism and sclerotization in drosophila. I. Identification of the biochemical defect in Dox-A2 [l(2)37Bf] mutants. Pentz ES, et al. Genetics, 1986 Apr. PMID 3082714, Free PMC Article
  2. Drosophila melanogaster diphenol oxidase A2: gene structure and homology with the mouse mast-cell tum- transplantation antigen, P91A. Pentz ES, et al. Gene, 1991 Jul 22. PMID 1909680
  3. Hemolymph coagulation and phenoloxidase in Drosophila larvae. Bidla G, et al. Dev Comp Immunol, 2005. PMID 15854679
  4. Homologues of 26S proteasome subunits are regulators of transcription and translation. Aravind L, et al. Protein Sci, 1998 May. PMID 9605331, Free PMC Article
  5. Identification of PSMB5 as a genetic modifier of fragile X-associated tremor/ataxia syndrome. Kong HE, et al. Proc Natl Acad Sci U S A, 2022 May 31. PMID 35617426, Free PMC Article

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables enzyme regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
Inferred by Curator
more info
 PubMed 
involved_in regulation of protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of proteasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome regulatory particle IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome regulatory particle ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of proteasome regulatory particle, lid subcomplex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome regulatory particle, lid subcomplex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
regulatory particle non-ATPase 3
Names
3
CG42641-PA
CG42641-PB
Rpn3-PA
Rpn3-PB
diphenol oxidase A2
diphenol oxidase-A2
regulatory particle nonATPase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    19051790..19053681
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057952.4 → NP_477300.1  regulatory particle non-ATPase 3, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477300.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B5RIX5, P25161, Q8T460, Q9VJ09
    UniProtKB/TrEMBL
    M9PG62
    Related
    FBpp0291495
    Conserved Domains (2) summary
    pfam01399
    Location:320 → 413
    PCI; PCI domain
    pfam08375
    Location:426 → 484
    Rpn3_C; Proteasome regulatory subunit C-terminal

  2. NM_001273628.1 → NP_001260557.1  regulatory particle non-ATPase 3, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260557.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B5RIX5, P25161, Q8T460, Q9VJ09
    UniProtKB/TrEMBL
    M9PG62
    Conserved Domains (2) summary
    pfam01399
    Location:320 → 413
    PCI; PCI domain
    pfam08375
    Location:426 → 484
    Rpn3_C; Proteasome regulatory subunit C-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PG62 M9PG62
P25161.1 P25161

Gene LinkOut

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