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Prosbeta4 Proteasome beta4 subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34999, updated on 5-May-2024

Summary

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Official Symbol
Prosbeta4provided by FlyBase
Official Full Name
Proteasome beta4 subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0032596
Locus tag
Dmel_CG17331
See related
AllianceGenome:FB:FBgn0032596
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
17331; beta-4; Beta-4; beta4; CG17331; Dmel\CG17331; GC17331; Pros beta4; Psmb2; PSMB2
Summary
Predicted to enable peptidase activity. Involved in multicellular organism reproduction and proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome core complex. Is expressed in adult head and adult heart. Orthologous to human PSMB2 (proteasome 20S subunit beta 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
36A12-36A12; 2-52 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (16731180..16732133, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (16731180..16732133, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene tRNA splicing endonuclease subunit 2 Neighboring gene uncharacterized protein Neighboring gene NUBP iron-sulfur cluster assembly factor 1 Neighboring gene gluon Neighboring gene Chitin and LDLR binding deacetylase 3 Neighboring gene Like Sm 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Activation of the ubiquitin-proteasome system contributes to oculopharyngeal muscular dystrophy through muscle atrophy. Ribot C, et al. PLoS Genet, 2022 Jan. PMID 35025870, Free PMC Article
  2. Proteasome Structure and Assembly. Budenholzer L, et al. J Mol Biol, 2017 Nov 10. PMID 28583440, Free PMC Article
  3. Sperm competitive ability in Drosophila melanogaster associated with variation in male reproductive proteins. Fiumera AC, et al. Genetics, 2005 Jan. PMID 15466425, Free PMC Article
  4. Actomyosin contraction during cellularization is regulated in part by Src64 control of Actin 5C protein levels. Carter TY, et al. Genesis, 2019 Jun. PMID 30974046
  5. Identification of the stress granule transcriptome via RNA-editing in single cells and in vivo. van Leeuwen W, et al. Cell Rep Methods, 2022 Jun 20. PMID 35784648, Free PMC Article

See all (63) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables peptidase activity IKR
Inferred from Key Residues
more info
  
NOT enables peptidase activity NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in proteasomal protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
Inferred by Curator
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis involved in protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sexual reproduction IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome core complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome core complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome core complex, beta-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome core complex, beta-subunit complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
proteasome beta4 subunit
Names
CG17331-PA
CG17331-PB
Prosbeta4-PA
Prosbeta4-PB
beta4

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    16731180..16732133 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273582.1 → NP_001260511.1  proteasome beta4 subunit, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260511.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VJJ0
    Conserved Domains (2) summary
    COG0638
    Location:1 → 194
    PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
    cd03758
    Location:1 → 192
    proteasome_beta_type_2; proteasome beta type-2 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

  2. NM_135960.4 → NP_609804.1  proteasome beta4 subunit, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609804.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VJJ0
    Related
    FBpp0080490
    Conserved Domains (2) summary
    COG0638
    Location:1 → 194
    PRE1; 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]
    cd03758
    Location:1 → 192
    proteasome_beta_type_2; proteasome beta type-2 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VJJ0 Q9VJJ0

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