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Art8 Arginine methyltransferase 8 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34528, updated on 10-May-2024

Summary

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Official Symbol
Art8provided by FlyBase
Official Full Name
Arginine methyltransferase 8provided by FlyBase
Primary source
FLYBASE:FBgn0032329
Locus tag
Dmel_CG16840
See related
AllianceGenome:FB:FBgn0032329
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG16840; dART8; Dart8; DART8; Dmel\CG16840
Summary
Enables histone methyltransferase activity (H3-R2 specific). Involved in histone H3-R2 methylation and peptidyl-arginine N-methylation. Located in nucleus. Is expressed in embryonic/larval midgut; embryonic/larval muscle system; organism; and ovary. Orthologous to human PRMT6 (protein arginine methyltransferase 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
32C1-32C1; 2-44 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (11009821..11011086, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (11009821..11011086, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene lectin-33A Neighboring gene Ribosomal protein L9 Neighboring gene Nucleoporin 154kD Neighboring gene antisense RNA:CR45778 Neighboring gene Deoxyuridine triphosphatase Neighboring gene SAM-motif ubiquitously expressed punctatedly localized protein Neighboring gene Accessory gland protein 32CD

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Developmental regulation of N-terminal H2B methylation in Drosophila melanogaster. Villar-Garea A, et al. Nucleic Acids Res, 2012 Feb. PMID 22053083, Free PMC Article
  2. Protein arginine methyltransferase 6 enhances polyglutamine-expanded androgen receptor function and toxicity in spinal and bulbar muscular atrophy. Scaramuzzino C, et al. Neuron, 2015 Jan 7. PMID 25569348, Free PMC Article
  3. A novel BLAST-Based Relative Distance (BBRD) method can effectively group members of protein arginine methyltransferases and suggest their evolutionary relationship. Wang YC, et al. Mol Phylogenet Evol, 2015 Mar. PMID 25576770
  4. Characterization of the Drosophila protein arginine methyltransferases DART1 and DART4. Boulanger MC, et al. Biochem J, 2004 Apr 15. PMID 14705965, Free PMC Article
  5. The 18S ribosomal RNA m(6) A methyltransferase Mettl5 is required for normal walking behavior in Drosophila. Leismann J, et al. EMBO Rep, 2020 Jul 3. PMID 32350990, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables histone H3R2 methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables histone methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-arginine N-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-arginine omega-N asymmetric methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-arginine omega-N monomethyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
arginine methyltransferase 8
Names
Art8-PA
CG16840-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    11009821..11011086 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135634.2 → NP_609478.1  arginine methyltransferase 8 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609478.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SX32, Q9VKL4
    Related
    FBpp0079751
    Conserved Domains (2) summary
    COG0500
    Location:1 → 244
    SmtA; SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only]
    pfam12847
    Location:40 → 147
    Methyltransf_18; Methyltransferase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8SX32 Q8SX32

Gene LinkOut

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