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CG31871 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34463, updated on 10-May-2024

Summary

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Official Symbol
CG31871provided by FlyBase
Primary source
FLYBASE:FBgn0051871
Locus tag
Dmel_CG31871
See related
AllianceGenome:FB:FBgn0051871
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG17087; CG17099; Dmel\CG31871
Summary
Predicted to enable triglyceride lipase activity. Is expressed in several structures, including anlage in statu nascendi; ectoderm anlage; extended germ band embryo; gut section; and trunk ectoderm. Human ortholog(s) of this gene implicated in Wolman disease; autosomal recessive congenital ichthyosis 8; cholesterol ester storage disease; and lysosomal and lipase deficiency. Orthologous to several human genes including LIPA (lipase A, lysosomal acid type); LIPF (lipase F, gastric type); and LIPK (lipase family member K). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See CG31871 in Genome Data Viewer
Location:
32A2-32A3; 2-43 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10662081..10671487)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10662081..10671487)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45692 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44180

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Perturbation of the Akt/Gsk3-β signalling pathway is common to Drosophila expressing expanded untranslated CAG, CUG and AUUCU repeat RNAs. van Eyk CL, et al. Hum Mol Genet, 2011 Jul 15. PMID 21518731, Free PMC Article
  2. Comparative and functional genomics of lipases in holometabolous insects. Horne I, et al. Insect Biochem Mol Biol, 2009 Aug. PMID 19540341
  3. Identification of neural outgrowth genes using genome-wide RNAi. Sepp KJ, et al. PLoS Genet, 2008 Jul 4. PMID 18604272, Free PMC Article
  4. Global analysis of patterns of gene expression during Drosophila embryogenesis. Tomancak P, et al. Genome Biol, 2007. PMID 17645804, Free PMC Article
  5. Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells. Parkhitko AA, et al. PLoS Genet, 2021 Feb. PMID 33591981, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables triglyceride lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG31871-PA
NP_723607.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10662081..10671487
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_164939.2 → NP_723607.1  uncharacterized protein Dmel_CG31871 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_723607.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VKS5
    Related
    FBpp0079693
    Conserved Domains (3) summary
    COG0596
    Location:93 → 436
    MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    pfam04083
    Location:79 → 133
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:115 → 281
    Abhydrolase_5; Alpha/beta hydrolase family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VKS5 Q9VKS5

Gene LinkOut

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