U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

holn1 hole-in-one [ Drosophila melanogaster (fruit fly) ]

Gene ID: 34432, updated on 10-May-2024

Summary

Go to the top of the page Help
Official Symbol
holn1provided by FlyBase
Official Full Name
hole-in-oneprovided by FlyBase
Primary source
FLYBASE:FBgn0032250
Locus tag
Dmel_CG5198
See related
AllianceGenome:FB:FBgn0032250
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG5198; Dmel\CG5198
Summary
Involved in positive regulation of wound healing; sensory organ development; and wing disc development. Located in nucleus. Is expressed in organism. Orthologous to human CD2BP2 (CD2 cytoplasmic tail binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
31E2-31E2; 2-42 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10435995..10437316)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10435995..10437316)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Basal body up regulated gene 22 Neighboring gene Transcription factor IIB Neighboring gene TBC1 domain family member 16 Neighboring gene STIP1 homology and U-box containing protein 1 Neighboring gene Non-SMC element 4

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Hole-in-one mutant phenotypes link EGFR/ERK signaling to epithelial tissue repair in Drosophila. Geiger JA, et al. PLoS One, 2011. PMID 22140578, Free PMC Article
  2. Transposable elements contribute to the genomic response to insecticides in Drosophila melanogaster. Salces-Ortiz J, et al. Philos Trans R Soc Lond B Biol Sci, 2020 Mar 30. PMID 32075557, Free PMC Article
  3. Genetic screen in Drosophila melanogaster uncovers a novel set of genes required for embryonic epithelial repair. Campos I, et al. Genetics, 2010 Jan. PMID 19884309, Free PMC Article
  4. High-resolution protein interaction map of the Drosophila melanogaster p38 mitogen-activated protein kinases reveals limited functional redundancy. Belozerov VE, et al. Mol Cell Biol, 2012 Sep. PMID 22801366, Free PMC Article
  5. Population distribution analyses reveal a hierarchy of molecular players underlying parallel endocytic pathways. Gupta GD, et al. PLoS One, 2014. PMID 24971745, Free PMC Article

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Holn1 acts downstream of EGFR and ERK signaling in the Grh/Fos mediated wound closure pathway.
    Title: Hole-in-one mutant phenotypes link EGFR/ERK signaling to epithelial tissue repair in Drosophila.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in chaeta development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in compound eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of wound healing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in wing disc development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in wound healing HMP PubMed 
Component Evidence Code Pubs
part_of U5 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U5 snRNP IEA
Inferred from Electronic Annotation
more info
  
part_of U5 snRNP ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
hole-in-one
Names
CG5198-PA
holn1-PA

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    10435995..10437316
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135560.3 → NP_609404.2  hole-in-one [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    C4XVH8, Q8T0Q7, Q9VKV5
    Related
    FBpp0079616
    Conserved Domains (1) summary
    cd00072
    Location:260 → 318
    GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VKV5.1 Q9VKV5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous