Srp54 Splicing regulatory protein 54 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Srp54provided by FlyBase
Official Full Name: Splicing regulatory protein 54provided by FlyBase
Primary source: FLYBASE:FBgn0024285
Locus tag: Dmel_CG4602
See related: AllianceGenome:FB:FBgn0024285
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-EST:Liang-2.16; CG4602; clone 2.16; Dmel\CG4602; dSRp54; p75; srp54; SRp54; SRP54
Summary: Enables mRNA binding activity and poly-pyrimidine tract binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome; regulation of mRNA 3'-end processing; and regulation of transcriptional start site selection at RNA polymerase II promoter. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Is expressed in adult head; embryonic brain; larval ventral nerve cord; and organism. Orthologous to several human genes including SRSF11 (serine and arginine rich splicing factor 11). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (9912911..9915044)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (9912911..9915044)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables poly-pyrimidine tract binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in mRNA splicing, via spliceosome	IC Inferred by Curator more info	PubMed
involved_in mRNA splicing, via spliceosome	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	HMP more info	PubMed
involved_in regulation of alternative mRNA splicing, via spliceosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of mRNA 3'-end processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcriptional start site selection at RNA polymerase II promoter	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of catalytic step 2 spliceosome	HDA more info	PubMed
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IC Inferred by Curator more info	PubMed
part_of precatalytic spliceosome	HDA more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain