sult2st1 sulfotransferase family 2, cytosolic sulfotransferase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sult2st1provided by ZNC
Official Full Name: sulfotransferase family 2, cytosolic sulfotransferase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030219-114
See related: Ensembl:ENSDARG00000033170 AllianceGenome:ZFIN:ZDB-GENE-030219-114
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: sult2st; id:ibd1140
Summary: Enables sulfotransferase activity and sulfurtransferase activity. Predicted to be involved in sulfation. Predicted to be active in cytoplasm. Is expressed in blood; cardiovascular system; digestive system; and yolk syncytial layer. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 14 and prostate cancer. Orthologous to human SULT2A1 (sulfotransferase family 2A member 1) and SULT2B1 (sulfotransferase family 2B member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	12	NC_007123.7 (630295..645972, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	12	NC_007123.6 (624354..640031, complement)

Chromosome 12 - NC_007123.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This protein was isolated, characterized and examined for enzymatic activities using a variety of endogenous compounds as substrates.
Title: Characterization of a zebrafish estrogen-sulfating cytosolic sulfotransferase: inhibitory effects and mechanism of action of phytoestrogens.
SULT2 ST2 and SULT2 ST3 showed distinct patterns of expression during embryonic development and throughout the larval stage onto maturity.
Title: Identification of novel hydroxysteroid-sulfating cytosolic SULTs, SULT2 ST2 and SULT2 ST3, from zebrafish: cloning, expression, characterization, and developmental expression.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables sulfotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sulfotransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables sulfotransferase activity	IEA Inferred from Electronic Annotation more info
enables sulfurtransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in sulfation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sulfotransferase family 2, cytosolic sulfotransferase 1

Names: sulfotransferase family, cytosolic sulfotransferase 2

NP_944596.2

EC 2.8.2.-

XP_005156055.1

EC 2.8.2.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198914.2 → NP_944596.2 sulfotransferase family 2, cytosolic sulfotransferase 1

See identical proteins and their annotated locations for NP_944596.2

Status: PROVISIONAL

Source sequence(s)

BC064294

UniProtKB/TrEMBL

Q6P2U4

Related

ENSDARP00000048631.5, ENSDART00000048632.8

Conserved Domains (1) summary

pfam00685
Location:35 → 279

Sulfotransfer_1; Sulfotransferase domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007123.7 Reference GRCz11 Primary Assembly

Range

630295..645972 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005155998.3 → XP_005156055.1 sulfotransferase family 2, cytosolic sulfotransferase 1 isoform X1

UniProtKB/TrEMBL

A0A8M2B2C8, E7F734

Related

ENSDARP00000097437.3, ENSDART00000106659.5

Conserved Domains (1) summary

pfam00685
Location:35 → 279

Sulfotransfer_1; Sulfotransferase domain