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MYLK myosin light chain kinase [ Bos taurus (cattle) ]

Gene ID: 338037, updated on 5-Mar-2024

Summary

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Gene symbol
MYLK
Gene description
myosin light chain kinase
See related
BGD:BT26108; Ensembl:ENSBTAG00000014567
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as
MLCK; smMLCK
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 1 NC_037328.1 (67980544..68260061, complement)

Chromosome 1 - NC_037328.1Genomic Context describing neighboring genes Neighboring gene 3-hydroxyacyl-CoA dehydratase 2 Neighboring gene histone H4-like Neighboring gene large ribosomal subunit protein eL21-like Neighboring gene coiled-coil domain containing 14 Neighboring gene U4 spliceosomal RNA Neighboring gene rhophilin associated tail protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037328.1 Chromosome 1 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Histamine-induced myosin light chain phosphorylation breaks down the barrier integrity of cultured corneal epithelial cells. Guo Y, et al. Pharm Res, 2007 Oct. PMID 17479229
  2. Isolation of cDNA for bovine stomach 155 kDa protein exhibiting myosin light chain kinase activity. Kobayashi H, et al. J Biochem, 1992 Dec. PMID 1284247
  3. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Histamine induces myosin light chain (MLC)phosphorylation via MYLK, suggesting regulatory role for MLC in controlling corneal epithelial permeability.
    Title: Histamine-induced myosin light chain phosphorylation breaks down the barrier integrity of cultured corneal epithelial cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables myosin light chain kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tonic smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cleavage furrow IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in stress fiber IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
myosin light chain kinase, smooth muscle
Names
myosin, light polypeptide kinase
telokin
NP_001359183.1
NP_788809.1
XP_024850108.1
XP_024850288.1
XP_024850337.1
XP_059744877.1
XP_059744900.1
XP_059744905.1
XP_059744920.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001372254.1 → NP_001359183.1  myosin light chain kinase, smooth muscle isoform 2

    Status: VALIDATED

    Source sequence(s)
    NKLS02000001
    Related
    ENSBTAP00000019385.7, ENSBTAT00000019385.7
    Conserved Domains (7) summary
    PTZ00449
    Location:869 → 1281
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd00063
    Location:1400 → 1491
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14191
    Location:1531 → 1789
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    cd00096
    Location:293 → 358
    Ig; Immunoglobulin domain
    pfam07679
    Location:1879 → 1969
    I-set; Immunoglobulin I-set domain
    pfam16620
    Location:251 → 293
    23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
    cl11960
    Location:1307 → 1404
    Ig; Immunoglobulin domain

  2. NM_176636.3 → NP_788809.1  myosin light chain kinase, smooth muscle isoform 1

    See identical proteins and their annotated locations for NP_788809.1

    Status: VALIDATED

    Source sequence(s)
    NKLS02000001
    UniProtKB/Swiss-Prot
    Q28824
    UniProtKB/TrEMBL
    F1N269
    Conserved Domains (5) summary
    PTZ00449
    Location:60 → 361
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd00063
    Location:591 → 682
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14191
    Location:722 → 980
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    pfam07679
    Location:1069 → 1159
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:498 → 595
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037328.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    67980544..68260061 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059888917.1 → XP_059744900.1  myosin light chain kinase, smooth muscle isoform X1

    Related
    ENSBTAP00000084948.1, ENSBTAT00000090379.1

  2. XM_059888922.1 → XP_059744905.1  myosin light chain kinase, smooth muscle isoform X2

    Related
    ENSBTAP00000086784.1, ENSBTAT00000092412.1

  3. XM_059888894.1 → XP_059744877.1  myosin light chain kinase, smooth muscle isoform X1

  4. XM_024994340.2 → XP_024850108.1  myosin light chain kinase, smooth muscle isoform X1

    Related
    ENSBTAP00000088779.1, ENSBTAT00000104917.1
    Conserved Domains (6) summary
    cd00063
    Location:1543 → 1634
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:2022 → 2112
    I-set; Immunoglobulin I-set domain
    cd14191
    Location:1674 → 1932
    STKc_MLCK1; Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1
    pfam16620
    Location:251 → 411
    23ISL; Unstructured linker between I-set domains 2 and 3 on MYLCK
    cl11960
    Location:1450 → 1547
    Ig; Immunoglobulin domain
    cl25751
    Location:1012 → 1424
    DUF4045; Domain of unknown function (DUF4045)

  5. XM_024994520.2 → XP_024850288.1  myosin light chain kinase, smooth muscle isoform X3

    Conserved Domains (4) summary
    cd05762
    Location:38 → 135
    Ig8_hMLCK_like; Eighth immunoglobulin (Ig)-like domain of human myosin light-chain kinase (MLCK) and similar domains
    cd00063
    Location:131 → 222
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:610 → 700
    I-set; Immunoglobulin I-set domain
    cl21453
    Location:262 → 520
    PKc_like; Protein Kinases, catalytic domain

  6. XM_059888937.1 → XP_059744920.1  myosin light chain kinase, smooth muscle isoform X4

  7. XM_024994569.2 → XP_024850337.1  myosin light chain kinase, smooth muscle isoform X5

    Conserved Domains (1) summary
    cd20973
    Location:52 → 139
    IgI_telokin-like; immunoglobulin-like domain of telokin and similar proteins; a member of the I-set of IgSF domains
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q28824.1 GenPept UniProtKB/Swiss-Prot:Q28824

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