rps6kal ribosomal protein S6 kinase a, like [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rps6kalprovided by ZNC
Official Full Name: ribosomal protein S6 kinase a, likeprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-9616
See related: Ensembl:ENSDARG00000037574 AllianceGenome:ZFIN:ZDB-GENE-030131-9616
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: rps6ka6; zgc:66139; wu:fj94b02
Summary: Predicted to enable ribosomal protein S6 kinase activity. Predicted to be involved in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator and peptidyl-serine phosphorylation. Predicted to act upstream of or within intracellular signal transduction and protein phosphorylation. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human RPS6KA6 (ribosomal protein S6 kinase A6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (8947450..9002405)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (8641436..8696391)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables ribosomal protein S6 kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ribosomal protein S6 kinase alpha-6

Names: S6K-alpha 6-like; S6K-alpha-6; ribosomal protein S6 kinase polypeptide 6; ribosomal protein S6 kinase, like; zmp:0000001068

NP_956367.1

EC 2.7.11.1

XP_009305993.1

EC 2.7.11.1

XP_021336659.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200073.1 → NP_956367.1 ribosomal protein S6 kinase alpha-6

See identical proteins and their annotated locations for NP_956367.1

Status: PROVISIONAL

Source sequence(s)

BC057467

UniProtKB/Swiss-Prot

Q6PFQ0

Related

ENSDARP00000130163.1, ENSDART00000047993.8

Conserved Domains (3) summary

smart00220
Location:67 → 326

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd05582
Location:71 → 387

STKc_RSK_N; N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase

cd14177
Location:415 → 709

STKc_RSK4_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6)

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007125.7 Reference GRCz11 Primary Assembly

Range

8947450..9002405

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009307718.2 → XP_009305993.1 ribosomal protein S6 kinase alpha-6 isoform X1

UniProtKB/TrEMBL

A0A8M3B8E3

Conserved Domains (3) summary

smart00220
Location:258 → 515

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14177
Location:253 → 547

STKc_RSK4_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6)

cl21453
Location:1 → 225

PKc_like; Protein Kinases, catalytic domain
XM_021480984.1 → XP_021336659.1 ribosomal protein S6 kinase alpha-6 isoform X2

UniProtKB/TrEMBL

A0A8M9QGB2

Conserved Domains (2) summary

cd14177
Location:182 → 476

STKc_RSK4_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6)

cl21453
Location:1 → 154

PKc_like; Protein Kinases, catalytic domain