tollip toll interacting protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tollipprovided by ZNC
Official Full Name: toll interacting proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-8820
See related: Ensembl:ENSDARG00000098486 AllianceGenome:ZFIN:ZDB-GENE-030131-8820
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fk22a02; zgc:76985; im:7145391; wu:fk22a02
Summary: Predicted to enable ubiquitin binding activity and ubiquitin conjugating enzyme binding activity. Acts upstream of or within negative regulation of Wnt signaling pathway. Predicted to be active in cytoplasm. Orthologous to human TOLLIP (toll interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 7

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (72276507..72290604)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (72027216..72041313)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ubiquitin binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endosome	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: toll-interacting protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001328590.1 → NP_001315519.1 toll-interacting protein isoform 2

Status: VALIDATED

Source sequence(s)

CU463038, EH451009, EH562339, EH573127

UniProtKB/Swiss-Prot

Q6NYL4, Q7ZV43

UniProtKB/TrEMBL

A0A0R4IVK4, A0A8M1PAH8

Related

ENSDARP00000138745.1, ENSDART00000166544.2

Conserved Domains (2) summary

cd04016
Location:28 → 148

C2_Tollip; C2 domain present in Toll-interacting protein (Tollip)

cd14363
Location:208 → 248

CUE_TOLIP; CUE domain found in the C-terminal of toll-interacting protein (Tollip) and similar proteins
NM_207061.2 → NP_996944.2 toll-interacting protein isoform 1

Status: VALIDATED

Source sequence(s)

EH448242, EH562339, EH573127

UniProtKB/Swiss-Prot

Q6NYL4, Q7ZV43

UniProtKB/TrEMBL

A0A0R4IZ33, A0A8N1TZ91

Related

ENSDARP00000140869.1, ENSDART00000172021.2