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rpl6 ribosomal protein L6 [ Danio rerio (zebrafish) ]

Gene ID: 336727, updated on 11-Apr-2024

Summary

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Official Symbol
rpl6provided by ZNC
Official Full Name
ribosomal protein L6provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-8671
See related
Ensembl:ENSDARG00000058451 AllianceGenome:ZFIN:ZDB-GENE-030131-8671
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
wu:fa93h05; wu:fb26a11; zgc:111805
Summary
Predicted to enable RNA binding activity. Predicted to be a structural constituent of ribosome. Acts upstream of or within chordate embryonic development and pancreas development. Predicted to be located in ribosome. Predicted to be part of cytosolic large ribosomal subunit. Is expressed in digestive system; endodermal cell; epithelial cell of pancreas; and lens. Orthologous to human RPL6 (ribosomal protein L6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See rpl6 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (2493794..2506356, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (2435251..2447813, complement)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene si:dkeyp-51b9.3 Neighboring gene dynein, light chain, LC8-type 1 Neighboring gene acetyl-CoA acyltransferase 2 Neighboring gene mitochondrial ribosomal protein L40

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Single-cell RNA-sequencing uncovers transcriptional states and fate decisions in haematopoiesis. Athanasiadis EI, et al. Nat Commun, 2017 Dec 11. PMID 29229905, Free PMC Article
  2. Identification and expression of carbonic anhydrase 2, myosin regulatory light chain 2 and selenium-binding protein 1 in zebrafish Danio rerio: Implication for age-related biomarkers. Feng S, et al. Gene Expr Patterns, 2018 Sep. PMID 29738878
  3. Ribosomal protein gene knockdown causes developmental defects in zebrafish. Uechi T, et al. PLoS One, 2006 Dec 20. PMID 17183665, Free PMC Article
  4. Multiple ribosomal proteins are expressed at high levels in developing zebrafish endoderm and are required for normal exocrine pancreas development. Provost E, et al. Zebrafish, 2013 Jun. PMID 23697888, Free PMC Article
  5. Many ribosomal protein mutations are associated with growth impairment and tumor predisposition in zebrafish. Lai K, et al. Dev Dyn, 2009 Jan. PMID 19097187, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC111805

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chordate embryonic development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within pancreas development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
60S ribosomal protein L6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003844.2 → NP_001003844.2  60S ribosomal protein L6

    Status: VALIDATED

    Source sequence(s)
    CT573399, EH584073
    UniProtKB/TrEMBL
    A0A0R4ILG7, A0A8N7XJI3, F6NWV4, Q567N5
    Related
    ENSDARP00000091899.4, ENSDART00000101125.5
    Conserved Domains (3) summary
    COG2163
    Location:117 → 241
    RPL14A; Ribosomal protein L14E/L6E/L27E [Translation, ribosomal structure and biogenesis]
    cd13156
    Location:113 → 265
    KOW_RPL6; KOW motif of Ribosomal Protein L6
    pfam03868
    Location:6 → 48
    Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain

  2. NM_001328586.1 → NP_001315515.1  60S ribosomal protein L6

    Status: VALIDATED

    Source sequence(s)
    CT573399, EH584073
    UniProtKB/TrEMBL
    A0A0R4ILG7, A0A8N7XJI3, F6NWV4, Q567N5
    Related
    ENSDARP00000107457.2, ENSDART00000125124.4
    Conserved Domains (3) summary
    COG2163
    Location:117 → 241
    RPL14A; Ribosomal protein L14E/L6E/L27E [Translation, ribosomal structure and biogenesis]
    cd13156
    Location:113 → 265
    KOW_RPL6; KOW motif of Ribosomal Protein L6
    pfam03868
    Location:6 → 48
    Ribosomal_L6e_N; Ribosomal protein L6, N-terminal domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    2493794..2506356 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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