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rpl10 ribosomal protein L10 [ Danio rerio (zebrafish) ]

Gene ID: 336712, updated on 27-Mar-2024

Summary

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Official Symbol
rpl10provided by ZNC
Official Full Name
ribosomal protein L10provided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-8656
See related
Ensembl:ENSDARG00000025581 AllianceGenome:ZFIN:ZDB-GENE-030131-8656
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
QM; rpl-10; fa93d03; zgc:56154; QM protein; wu:fa93d03
Summary
Enables translation regulator activity. Involved in embryonic brain development and regulation of translation. Acts upstream of or within brain development. Predicted to be located in ribosome. Predicted to be part of cytosolic large ribosomal subunit. Is expressed in head and midbrain hindbrain boundary. Human ortholog(s) of this gene implicated in autistic disorder and syndromic X-linked mental retardation 35. Orthologous to several human genes including RPL10 (ribosomal protein L10). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 23
Exon count:
7
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 23 NC_007134.7 (19712556..19715814, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 23 NC_007134.6 (19786213..19789471, complement)

Chromosome 23 - NC_007134.7Genomic Context describing neighboring genes Neighboring gene si:dkey-93l1.6 Neighboring gene deoxyribonuclease I-like 1 Neighboring gene filamin A, alpha (actin binding protein 280) Neighboring gene emerin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. A novel ribosomopathy caused by dysfunction of RPL10 disrupts neurodevelopment and causes X-linked microcephaly in humans. Brooks SS, et al. Genetics, 2014 Oct. PMID 25316788, Free PMC Article
  2. Abnormal development of zebrafish after knockout and knockdown of ribosomal protein L10a. Palasin K, et al. Sci Rep, 2019 Dec 2. PMID 31792295, Free PMC Article
  3. Biotagging of Specific Cell Populations in Zebrafish Reveals Gene Regulatory Logic Encoded in the Nuclear Transcriptome. Trinh LA, et al. Cell Rep, 2017 Apr 11. PMID 28402863, Free PMC Article
  4. Waterborne microcystin-LR exposure induced chronic inflammatory response via MyD88-dependent toll-like receptor signaling pathway in male zebrafish. Lin W, et al. Sci Total Environ, 2020 Feb 1. PMID 31710851
  5. Transcriptomic analyses of sexual dimorphism of the zebrafish liver and the effect of sex hormones. Zheng W, et al. PLoS One, 2013. PMID 23349717, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Abnormal development of zebrafish after knockout and knockdown of ribosomal protein L10a.
    Title: Abnormal development of zebrafish after knockout and knockdown of ribosomal protein L10a.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
  
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
  
enables translation regulator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryonic brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ribosomal large subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of cytosolic large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
located_in ribosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
large ribosomal subunit protein uL16; 60S ribosomal protein L10
Names
associated with tumor suppression, cell growth, differentiation, development and apoptosis
protein QM
NP_956321.1
XP_017209012.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200027.1 → NP_956321.1  large ribosomal subunit protein uL16

    See identical proteins and their annotated locations for NP_956321.1

    Status: PROVISIONAL

    Source sequence(s)
    BC045950
    UniProtKB/Swiss-Prot
    Q7ZV96
    Related
    ENSDARP00000120909.1, ENSDART00000131860.3
    Conserved Domains (1) summary
    PTZ00173
    Location:1 → 209
    PTZ00173; 60S ribosomal protein L10; Provisional

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007134.7 Reference GRCz11 Primary Assembly

    Range
    19712556..19715814 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017353523.1 → XP_017209012.1  60S ribosomal protein L10 isoform X1

    UniProtKB/Swiss-Prot
    Q7ZV96
    Related
    ENSDARP00000036951.7, ENSDART00000032744.9
    Conserved Domains (1) summary
    PTZ00173
    Location:1 → 209
    PTZ00173; 60S ribosomal protein L10; Provisional

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395142.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    40551..43805 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_2

Genomic

  1. NW_018395361.1 Reference GRCz11 ALT_DRER_TU_2

    Range
    256192..259532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7ZV96.1 GenPept UniProtKB/Swiss-Prot:Q7ZV96

Gene LinkOut

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